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Transferability of ...
Transferability of tag SNPs in genetic association studies in multiple populations
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de Bakker, Paul I. W. (author)
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Burtt, Noel P. (author)
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Graham, Robert R. (author)
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Guiducci, Candace (author)
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Yelensky, Roman (author)
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Drake, Jared A. (author)
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Bersaglieri, Todd (author)
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Penney, Kathryn L. (author)
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Butler, Johannah (author)
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Young, Stanton (author)
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Onofrio, Robert C. (author)
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Lyon, Helen N. (author)
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O Stram, Daniel (author)
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Haiman, Christopher A. (author)
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Freedman, Matthew L. (author)
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Zhu, Xiaofeng (author)
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Cooper, Richard (author)
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- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Kolonel, Laurence N. (author)
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Henderson, Brian E. (author)
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Daly, Mark J. (author)
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Hirschhorn, Joel N. (author)
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Altshuler, David (author)
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(creator_code:org_t)
- 2006-10-22
- 2006
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 38:11, s. 1298-1303
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- A general question for linkage disequilibrium-based association studies is how power to detect an association is compromised when tag SNPs are chosen from data in one population sample and then deployed in another sample. Specifically, it is important to know how well tags picked from the HapMap DNA samples capture the variation in other samples. To address this, we collected dense data uniformly across the four HapMap population samples and eleven other population samples. We picked tag SNPs using genotype data we collected in the HapMap samples and then evaluated the effective coverage of these tags in comparison to the entire set of common variants observed in the other samples. We simulated case-control association studies in the non-HapMap samples under a disease model of modest risk, and we observed little loss in power. These results demonstrate that the HapMap DNA samples can be used to select tags for genome-wide association studies in many samples around the world.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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de Bakker, Paul ...
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Burtt, Noel P.
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Graham, Robert R ...
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Guiducci, Candac ...
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Yelensky, Roman
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Drake, Jared A.
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show more...
-
Bersaglieri, Tod ...
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Penney, Kathryn ...
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Butler, Johannah
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Young, Stanton
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Onofrio, Robert ...
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Lyon, Helen N.
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O Stram, Daniel
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Haiman, Christop ...
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Freedman, Matthe ...
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Zhu, Xiaofeng
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Cooper, Richard
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Groop, Leif
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Kolonel, Laurenc ...
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Henderson, Brian ...
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Daly, Mark J.
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Hirschhorn, Joel ...
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Altshuler, David
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Nature Genetics
- By the university
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Lund University