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Evaluation of the A...
Evaluation of the Association between Persistent Organic Pollutants (POPs) and Diabetes in Epidemiological Studies: A National Toxicology Program Workshop Review
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Taylor, Kyla W. (author)
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Novak, Raymond F. (author)
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Anderson, Henry A. (author)
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show more...
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Birnbaum, Linda S. (author)
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Blystone, Chad (author)
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DeVito, Michael (author)
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Jacobs, David (author)
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Koehrle, Josef (author)
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Lee, Duk-Hee (author)
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- Rylander, Lars (author)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine
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- Rignell-Hydbom, Anna (author)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine
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Tornero-Velez, Rogelio (author)
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Turyk, Mary E. (author)
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi
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Thayer, Kristina A. (author)
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Lind, Lars (author)
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(creator_code:org_t)
- Environmental Health Perspectives, 2013
- 2013
- English.
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In: Environmental Health Perspectives. - : Environmental Health Perspectives. - 1552-9924 .- 0091-6765. ; 121:7, s. 774-783
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Abstract
Subject headings
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- BACKGROUND: Diabetes is a major threat to public health in the United States and worldwide. Understanding the role of environmental chemicals in the development or progression of diabetes is an emerging issue in environmental health. OBJECTIVE: We assessed the epidemiologic literature for evidence of associations between persistent organic pollutants (POPs) and type 2 diabetes. METHODS: Using a PubMed search and reference lists from relevant studies or review articles, we identified 72 epidemiological studies that investigated associations of persistent organic pollutants (POPs) with diabetes. We evaluated these studies for consistency, strengths and weaknesses of study design (including power and statistical methods), clinical diagnosis, exposure assessment, study population characteristics, and identification of data gaps and areas for future research. CONCLUSIONS: Heterogeneity of the studies precluded conducting a meta-analysis, but the overall evidence is sufficient for a positive association of some organochlorine POPs with type 2 diabetes. Collectively, these data are not sufficient to establish causality. Initial data mining revealed that the strongest positive correlation of diabetes with POPs occurred with organochlorine compounds, such as trans-nonachlor, dichlorodiphenyldichloroethylene (DDE), polychlorinated biphenyls (PCBs), and dioxins and dioxin-like chemicals. There is less indication of an association between other nonorganochlorine POPs, such as perfluoroalkyl acids and brominated compounds, and type 2 diabetes. Experimental data are needed to confirm the causality of these POPs, which will shed new light on the pathogenesis of diabetes. This new information should be considered by governmental bodies involved in the regulation of environmental contaminants.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- chemically induced
- diabetes
- environment
- epidemiology
- glucose
- hormone
- insulin
- metabolic syndrome
- obesity
- persistent organic
- pollutants
- pollution
- toxicology
- chemically induced
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- ref (subject category)
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- By the author/editor
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Taylor, Kyla W.
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Novak, Raymond F ...
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Anderson, Henry ...
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Birnbaum, Linda ...
-
Blystone, Chad
-
DeVito, Michael
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show more...
-
Jacobs, David
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Koehrle, Josef
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Lee, Duk-Hee
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Rylander, Lars
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Rignell-Hydbom, ...
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Tornero-Velez, R ...
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Turyk, Mary E.
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Lind, Lars
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Thayer, Kristina ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
- Articles in the publication
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Environmental He ...
- By the university
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Lund University
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Uppsala University