Central administration of resistin promotes short-term satiety in rats.

• OBJECTIVE: Several hormones expressed in white adipose tissue influence food intake at the central level. We sought to determine whether resistin, a circulating adipose-derived hormone in rodents, has actions on the hypothalamus by determining the effects of central resistin injection on food intake and on hypothalamic Fos protein expression. DESIGN: As resistin expression in adipose tissue is influenced by altered nutritional status, we studied the effect of central resistin in both fed and pre-fasted rats. RESULTS: In fasted rats, central injection of resistin decreased food intake acutely and increased the number of cells that express Fos protein in the arcuate nucleus but not in any other hypothalamic structure. The effect on food intake was dose-dependent and did not result in the formation of a conditioned taste aversion. CONCLUSIONS: Taken together, these results provide the first evidence documenting a central action of resistin, which could be involved in a feedback loop targeting the hypothalamus. On the other hand, since we observed resistin mRNA in the arcuate and ventromedial nuclei of the hypothalamus, it is also possible that brain-derived resistin serves as a neuropeptide involved in the regulation of energy homeostasis. However, since resistin-induced satiety was modest and transient, as central administration for several days did not affect body weight, the physiological relevance and therapeutic potential of the observed principal phenomenon may be limited.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Physiology (hsv//eng)

Nyckelord

Adiponectin

Animals

Body Weight

drug effects

Eating

drug effects

physiology

Hormones

Ectopic

pharmacology

Hypothalamus

drug effects

metabolism

Immunohistochemistry

In Situ Hybridization

Injections

Intraventricular

Insulin

blood

Intercellular Signaling Peptides and Proteins

blood

Leptin

blood

Male

Proto-Oncogene Proteins c-fos

metabolism

RNA

Messenger

genetics

Rats

Resistin

Satiety Response

drug effects

physiology

Statistics

Nonparametric

Taste

physiology

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)