Circulating Metabolomic and Lipidomic Signatures Identify a Type 2 Diabetes Risk Profile in Low-Birth-Weight Men with Non-Alcoholic Fatty Liver Disease

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Fältnamn	Indikatorer	Metadata
000		04164naa a2200505 4500
001		oai:lup.lub.lu.se:0120c14c-1e4a-4391-9da9-4ed82599d366
003		SwePub
008		230807s2023 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/0120c14c-1e4a-4391-9da9-4ed82599d3662 URI
024	7	a https://doi.org/10.3390/nu150715902 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Elingaard-Larsen, Line O.u Steno Diabetes Center Copenhagen4 aut
245	1 0	a Circulating Metabolomic and Lipidomic Signatures Identify a Type 2 Diabetes Risk Profile in Low-Birth-Weight Men with Non-Alcoholic Fatty Liver Disease
264		c 2023-03-24
264	1	b MDPI AG,c 2023
520		a The extent to which increased liver fat content influences differences in circulating metabolites and/or lipids between low-birth-weight (LBW) individuals, at increased risk of type 2 diabetes (T2D), and normal-birth-weight (NBW) controls is unknown. The objective of the study was to perform untargeted serum metabolomics and lipidomics analyses in 26 healthy, non-obese early-middle-aged LBW men, including five men with screen-detected and previously unrecognized non-alcoholic fatty liver disease (NAFLD), compared with 22 age- and BMI-matched NBW men (controls). While four metabolites (out of 65) and fifteen lipids (out of 279) differentiated the 26 LBW men from the 22 NBW controls (p ≤ 0.05), subgroup analyses of the LBW men with and without NAFLD revealed more pronounced differences, with 11 metabolites and 56 lipids differentiating (p ≤ 0.05) the groups. The differences in the LBW men with NAFLD included increased levels of ornithine and tyrosine (PFDR ≤ 0.1), as well as of triglycerides and phosphatidylcholines with shorter carbon-chain lengths and fewer double bonds. Pathway and network analyses demonstrated downregulation of transfer RNA (tRNA) charging, altered urea cycling, insulin resistance, and an increased risk of T2D in the LBW men with NAFLD. Our findings highlight the importance of increased liver fat in the pathogenesis of T2D in LBW individuals.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653		a lipidomics
653		a liver fat
653		a low-birth-weight
653		a metabolomics
653		a non-alcoholic fatty liver disease
653		a type 2 diabetes
700	1	a Villumsen, Sofie O.u Steno Diabetes Center Copenhagen4 aut
700	1	a Justesen, Louiseu Steno Diabetes Center Copenhagen4 aut
700	1	a Thuesen, Anne Cathrine B.u University of Copenhagen,Novo Nordisk Foundation Centre for Basic Metabolic Research4 aut
700	1	a Kim, Minu Steno Diabetes Center Copenhagen4 aut
700	1	a Ali, Minau Steno Diabetes Center Copenhagen4 aut
700	1	a Danielsen, Else R.u Copenhagen University Hospital4 aut
700	1	a Legido-Quigley, Cristinau Steno Diabetes Center Copenhagen4 aut
700	1	a van Hall, Gerritu Copenhagen University Hospital,University of Copenhagen4 aut
700	1	a Hansen, Torbenu Novo Nordisk Foundation Centre for Basic Metabolic Research,University of Copenhagen4 aut
700	1	a Ahluwalia, Tarunveer S.u Steno Diabetes Center Copenhagen,University of Copenhagen4 aut
700	1	a Vaag, Allan A.u Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups,Steno Diabetes Center Copenhagen4 aut0 (Swepub:lu)med-ava
700	1	a Brøns, Charlotteu Steno Diabetes Center Copenhagen4 aut
710	2	a Steno Diabetes Center Copenhagenb University of Copenhagen4 org
773	0	t Nutrientsd : MDPI AGg 15:7q 15:7x 2072-6643
856	4	u http://dx.doi.org/10.3390/nu15071590x freey FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/0120c14c-1e4a-4391-9da9-4ed82599d366
856	4 8	u https://doi.org/10.3390/nu15071590

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Av författaren/redakt...: Elingaard-Larsen ...; Villumsen, Sofie ...; Justesen, Louise; Thuesen, Anne Ca ...; Kim, Min; Ali, Mina; visa fler...; Danielsen, Else ...; Legido-Quigley, ...; van Hall, Gerrit; Hansen, Torben; Ahluwalia, Tarun ...; Vaag, Allan A.; Brøns, Charlotte; visa färre...

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