Search: WFRF:(Valenzuela Alejandro) >
Evolutionary constr...
Evolutionary constraint and innovation across hundreds of placental mammals
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- Christmas, Matthew (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
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- Kaplow, Irene M. (author)
- Carnegie Mellon Univ, Dept Computat Biol, Sch Comp Sci, Pittsburgh, PA 15213 USA.;Carnegie Mellon Univ, Neurosci Inst, Pittsburgh, PA 15213 USA.
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- Genereux, Diane P. (author)
- Broad Inst & Harvard, Cambridge, MA 02139 USA.
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show more...
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- Dong, Michael X. (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
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- Hughes, Graham M. (author)
- Univ Coll Dublin, Sch Biol & Environm Sci, Dublin 4, Ireland.
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- Li, Xue (author)
- UMass Chan Med Sch, Morningside Grad Sch Biomed Sci, Worcester, MA 01605 USA.;UMass Chan Med Sch, Program Bioinformat & Integrat Biol, Worcester, MA 01605 USA.
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- Sullivan, Patrick F. (author)
- Univ North Carolina Med Sch, Dept Genet, Chapel Hill, NC 27599 USA.;Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
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- Hindle, Allyson G. (author)
- Univ Nevada Vegas, Sch Life Sci, Las Vegas, NV 89154 USA.
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- Andrews, Gregory (author)
- UMass Chan Med Sch, Program Bioinformat & Integrat Biol, Worcester, MA 01605 USA.
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- Armstrong, Joel C. (author)
- Univ Maine, Sch Biol & Ecol, Orono, ME 04469 USA.
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- Bianchi, Matteo (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
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- Breit, Ana M. (author)
- Univ Maine, Sch Biol & Ecol, Orono, ME 04469 USA.
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- Diekhans, Mark (author)
- Univ Calif Santa Cruz, Genom Inst, Santa Cruz, CA 95064 USA.
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- Fanter, Cornelia (author)
- Univ Nevada Vegas, Sch Life Sci, Las Vegas, NV 89154 USA.
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- Foley, Nicole M. (author)
- Texas A&M Univ, Vet Integrat Biosci, College Stn, TX 77843 USA.
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- Goodman, Daniel B. (author)
- Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA.
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- Goodman, Linda (author)
- Fauna Bio Inc, Emeryville, CA 94608 USA.
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- Keough, Kathleen C. (author)
- Fauna Bio Inc, Emeryville, CA 94608 USA.;Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94158 USA.;Gladstone Inst, San Francisco, CA 94158 USA.
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- Kirilenko, Bogdan (author)
- Goethe Univ, Fac Biosci, D-60438 Frankfurt, Germany.;LOEWE Ctr Translat Biodivers Genom, D-60325 Frankfurt, Germany.;Senckenberg Res Inst, D-60325 Frankfurt, Germany.
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- Kowalczyk, Amanda (author)
- Carnegie Mellon Univ, Dept Computat Biol, Sch Comp Sci, Pittsburgh, PA 15213 USA.;Carnegie Mellon Univ, Neurosci Inst, Pittsburgh, PA 15213 USA.
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- Lawless, Colleen (author)
- Univ Coll Dublin, Sch Biol & Environm Sci, Dublin 4, Ireland.
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- Lind, Abigail L. (author)
- Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94158 USA.
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- Meadows, Jennifer R.S. (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
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- Moreira, Lucas R. (author)
- Broad Inst & Harvard, Cambridge, MA 02139 USA.;UMass Chan Med Sch, Program Bioinformat & Integrat Biol, Worcester, MA 01605 USA.
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- Redlich, Ruby W. (author)
- Carnegie Mellon Univ, Mellon Coll Sci, Dept Biol Sci, Pittsburgh, PA 15213 USA.
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- Ryan, Louise (author)
- Univ Coll Dublin, Sch Biol & Environm Sci, Dublin 4, Ireland.
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- Swofford, Ross (author)
- Broad Inst & Harvard, Cambridge, MA 02139 USA.
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- Valenzuela, Alejandro (author)
- Univ Pompeu Fabra, Inst Evolutionary Biol UPF CSIC, Dept Expt & Hlth Sci, Barcelona 08003, Spain.
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- Wagner, Franziska (author)
- Senckenberg Nat Hist Collect Dresden, Museum Zool, D-01109 Dresden, Germany.
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- Wallerman, Ola (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi
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- Brown, Ashley R. (author)
- Carnegie Mellon Univ, Dept Computat Biol, Sch Comp Sci, Pittsburgh, PA 15213 USA.
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- Damas, Joana (author)
- Univ Calif Davis, Genome Ctr, Davis, CA 95616 USA.
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- Fan, Kaili (author)
- UMass Chan Med Sch, Program Bioinformat & Integrat Biol, Worcester, MA 01605 USA.
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- Gatesy, John (author)
- Amer Museum Nat Hist, Div Vertebrate Zool, New York, NY 10024 USA.
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- Grimshaw, Jenna (author)
- Texas Tech Univ, Dept Biol Sci, Lubbock, TX 79409 USA.
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- Johnson, Jeremy (author)
- Broad Inst & Harvard, Cambridge, MA 02139 USA.
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- Kozyrev, Sergey V. (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
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- Lawler, Alyssa J. (author)
- Carnegie Mellon Univ, Neurosci Inst, Pittsburgh, PA 15213 USA.;Broad Inst & Harvard, Cambridge, MA 02139 USA.;Carnegie Mellon Univ, Mellon Coll Sci, Dept Biol Sci, Pittsburgh, PA 15213 USA.
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- Marinescu, Voichita (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi
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- Morrill, Kathleen M. (author)
- Broad Inst & Harvard, Cambridge, MA 02139 USA.;UMass Chan Med Sch, Morningside Grad Sch Biomed Sci, Worcester, MA 01605 USA.;UMass Chan Med Sch, Program Bioinformat & Integrat Biol, Worcester, MA 01605 USA.
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- Osmanski, Austin (author)
- Medical Scientist Training Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
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- Paulat, Nicole S. (author)
- Texas Tech Univ, Dept Biol Sci, Lubbock, TX 79409 USA.
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- Phan, BaDoi N. (author)
- Carnegie Mellon Univ, Dept Computat Biol, Sch Comp Sci, Pittsburgh, PA 15213 USA.;Carnegie Mellon Univ, Neurosci Inst, Pittsburgh, PA 15213 USA.;Univ Pittsburgh, Med Scientist Training Program, Sch Med, Pittsburgh, PA 15261 USA.
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- Reilly, Steven K. (author)
- Yale Sch Med, Dept Genet, New Haven, CT 06510 USA.
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- Schäffer, Daniel E. (author)
- Carnegie Mellon Univ, Dept Computat Biol, Sch Comp Sci, Pittsburgh, PA 15213 USA.
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- Steiner, Cynthia (author)
- San Diego Zoo Wildlife Alliance Escondido, Conservat Genet, Escondido, CA 92027 USA.
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- Supple, Megan A. (author)
- Univ Calif Santa Cruz, Dept Ecol & Evolutionary Biol, Santa Cruz, CA 95064 USA.
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- Wilder, Aryn P. (author)
- San Diego Zoo Wildlife Alliance Escondido, Conservat Genet, Escondido, CA 92027 USA.
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- Wirthlin, Morgan E. (author)
- Allen Inst Brain Sci, Seattle, WA 98109 USA.
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- Xue, James R. (author)
- Broad Inst & Harvard, Cambridge, MA 02139 USA.;Harvard Univ, Dept Organism & Evolutionary Biol, Cambridge, MA 02138 USA.
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- Birren, Bruce W. (author)
- Broad Inst & Harvard, Cambridge, MA 02139 USA.
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- Gazal, Steven (author)
- Univ Southern Calif, Keck Sch Med, Los Angeles, CA 90033 USA.
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- Hubley, Robert M. (author)
- Inst Syst Biol, Seattle, WA 98109 USA.
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- Koepfli, Klaus-Peter (author)
- Smithsonians Natl Zoo & Conservat Biol Inst, Ctr Species Survival, Washington, DC 20008 USA.;ITMO Univ, Comp Technol Lab, St Petersburg 197101, Russia.;George Mason Univ, Smithsonian Mason Sch Conservat, Front Royal, VA 22630 USA.
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- Marques-Bonet, Tomas (author)
- Catalan Inst Res & Adv Studies ICREA, Barcelona 08010, Spain.;Barcelona Inst Sci & Technol BIST, Ctr Genom Regulat, CNAG CRG, Barcelona 08036, Spain.;Univ Pompeu Fabra, Inst Evolutionary Biol UPF CSIC, Dept Med & Life Sci, Barcelona 08003, Spain.;Univ Autonoma Barcelona, Inst Catala Paleontol Miquel Crusafont, Cerdanyola Del Valles 08193, Barcelona, Spain.
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- Meyer, Wynn K. (author)
- Lehigh Univ, Dept Biol Sci, Bethlehem, PA 18015 USA.
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- Nweela, Martin (author)
- Case Western Reserve Univ, Sch Dent Med, Dept Comprehens Care, Cleveland, OH 44106 USA.;Canadian Museum Nat, Dept Vertebrate Zool, Ottawa, ON K2P 2R1, Canada.;Smithsonian Inst, Dept Vertebrate Zool, Washington, DC 20002 USA.;Harvard Sch Dent Med, Dept Restorat Dent & Biomat Sci, Narwhal Genome Initiat, Boston, MA 02115 USA.
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- Sabeti, Pardis C. (author)
- Broad Inst & Harvard, Cambridge, MA 02139 USA.;Harvard Univ, Dept Organism & Evolutionary Biol, Cambridge, MA 02138 USA.;Harvard Univ, Howard Hughes Med Inst, Cambridge, MA 02138 USA.
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- Shapiro, Beth (author)
- Univ Calif Santa Cruz, Dept Ecol & Evolutionary Biol, Santa Cruz, CA 95064 USA.;Univ Calif Santa Cruz, Howard Hughes Med Inst, Santa Cruz, CA 95064 USA.
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- Smit, Arian F. A. (author)
- Inst Syst Biol, Seattle, WA 98109 USA.
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- Springer, Mark S. (author)
- Univ Calif Riverside, Dept Evolut, Ecol & Organismal Biol, Riverside, CA 92521 USA.
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- Teeling, Emma C. (author)
- Univ Coll Dublin, Sch Biol & Environm Sci, Dublin 4, Ireland.
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- Weng, Zhiping (author)
- UMass Chan Med Sch, Program Bioinformat & Integrat Biol, Worcester, MA 01605 USA.
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- Hiller, Michael (author)
- Goethe Univ, Fac Biosci, D-60438 Frankfurt, Germany.;LOEWE Ctr Translat Biodivers Genom, D-60325 Frankfurt, Germany.;Senckenberg Res Inst, D-60325 Frankfurt, Germany.
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- Levesque, Danielle L. (author)
- Univ Maine, Sch Biol & Ecol, Orono, ME 04469 USA.
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- Lewin, Harris A. (author)
- Univ Calif Davis, Dept Evolut & Ecol, Davis, CA 95616 USA.;Univ Calif Davis, John Muir Inst Environm, Davis, CA 95616 USA.
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- Murphy, William J. (author)
- Texas A&M Univ, Vet Integrat Biosci, College Stn, TX 77843 USA.
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- Navarro, Arcadi (author)
- Catalan Inst Res & Adv Studies ICREA, Barcelona 08010, Spain.;Univ Pompeu Fabra, Inst Evolutionary Biol UPF CSIC, Dept Med & Life Sci, Barcelona 08003, Spain.;Pasqual Maragall Fdn, BarcelonaBeta Brain Res Ctr, Barcelona 08005, Spain.;Barcelona Inst Sci & Technol BIST, Ctr Genom Regulat, CRG, Barcelona 08003, Spain.
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- Paten, Benedict (author)
- Univ Calif Santa Cruz, Genom Inst, Santa Cruz, CA 95064 USA.
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- Pollard, Katherine S. (author)
- Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94158 USA.;Gladstone Inst, San Francisco, CA 94158 USA.;Chan Zuckerberg Biohub, San Francisco, CA 94158 USA.
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- Ray, David A. (author)
- Texas Tech Univ, Dept Biol Sci, Lubbock, TX 79409 USA.
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- Ruf, Irina (author)
- Senckenberg Res Inst, Div Messel Res & Mammal, D-60325 Frankfurt, Germany.;Nat Hist Museum Frankfurt, D-60325 Frankfurt, Germany.
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- Ryder, Oliver A. (author)
- Univ Calif San Diego, Sch Biol Sci, Dept Evolut Behav & Ecol, La Jolla, CA 92039 USA.
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- Pfenning, Andreas R. (author)
- Carnegie Mellon Univ, Neurosci Inst, Pittsburgh, PA 15213 USA.
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- Lindblad-Toh, Kerstin (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Broad Inst & Harvard, Cambridge, MA 02139 USA.
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- Karlsson, Elinor K. (author)
- Broad Inst & Harvard, Cambridge, MA 02139 USA.;UMass Chan Med Sch, Program Bioinformat & Integrat Biol, Worcester, MA 01605 USA.;UMass Chan Med Sch, Program Mol Med, Worcester, MA 01605 USA.
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(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2023
- 2023
- English.
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In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 380:6643
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Zoonomia is the largest comparative genomics resource for mammals produced to date. By aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect fitness and alter disease risk. At least 332 million bases (similar to 10.7%) in the human genome are unusually conserved across species (evolutionarily constrained) relative to neutrally evolving repeats, and 4552 ultraconserved elements are nearly perfectly conserved. Of 101 million significantly constrained single bases, 80% are outside protein-coding exons and half have no functional annotations in the Encyclopedia of DNA Elements (ENCODE) resource. Changes in genes and regulatory elements are associated with exceptional mammalian traits, such as hibernation, that could inform therapeutic development. Earth's vast and imperiled biodiversity offers distinctive power for identifying genetic variants that affect genome function and organismal phenotypes.
Subject headings
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Science
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To the university's database
- By the author/editor
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Christmas, Matth ...
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Kaplow, Irene M.
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Genereux, Diane ...
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Dong, Michael X.
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Hughes, Graham M ...
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Li, Xue
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show more...
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Sullivan, Patric ...
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Hindle, Allyson ...
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Andrews, Gregory
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Armstrong, Joel ...
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Bianchi, Matteo
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Breit, Ana M.
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Diekhans, Mark
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Fanter, Cornelia
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Foley, Nicole M.
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Goodman, Daniel ...
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Goodman, Linda
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Keough, Kathleen ...
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Kirilenko, Bogda ...
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Kowalczyk, Amand ...
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Lawless, Colleen
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Lind, Abigail L.
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Meadows, Jennife ...
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Moreira, Lucas R ...
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Redlich, Ruby W.
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Ryan, Louise
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Swofford, Ross
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Valenzuela, Alej ...
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Wagner, Franzisk ...
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Wallerman, Ola
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Brown, Ashley R.
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Damas, Joana
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Fan, Kaili
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Gatesy, John
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Grimshaw, Jenna
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Johnson, Jeremy
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Kozyrev, Sergey ...
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Lawler, Alyssa J ...
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Marinescu, Voich ...
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Morrill, Kathlee ...
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Osmanski, Austin
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Paulat, Nicole S ...
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Phan, BaDoi N.
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Reilly, Steven K ...
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Schäffer, Daniel ...
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Steiner, Cynthia
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Supple, Megan A.
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Wilder, Aryn P.
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Wirthlin, Morgan ...
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Xue, James R.
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Birren, Bruce W.
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Gazal, Steven
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Hubley, Robert M ...
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Koepfli, Klaus-P ...
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Marques-Bonet, T ...
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Meyer, Wynn K.
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Nweela, Martin
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Sabeti, Pardis C ...
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Shapiro, Beth
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Smit, Arian F. A ...
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Springer, Mark S ...
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Teeling, Emma C.
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Weng, Zhiping
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Hiller, Michael
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Levesque, Daniel ...
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Lewin, Harris A.
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Murphy, William ...
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Navarro, Arcadi
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Paten, Benedict
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Pollard, Katheri ...
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Ray, David A.
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Ruf, Irina
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Ryder, Oliver A.
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Pfenning, Andrea ...
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Lindblad-Toh, Ke ...
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Karlsson, Elinor ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Evolutionary Bio ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
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Science
- By the university
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Uppsala University
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Karolinska Institutet