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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003772naa a2200433 4500
001oai:lup.lub.lu.se:13ac1eec-6fa4-4afc-9e1d-507fb2f4366b
003SwePub
008160404s2009 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/14535352 URI
0247 a https://doi.org/10.1111/j.1600-6143.2009.02726.x2 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Ekberg, Henriku Lund University,Lunds universitet,Enheten för forskning kring njurfunktion och njursjukdom,Kirurgi,Forskargrupper vid Lunds universitet,Renal Research Unit,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)kir-hek
2451 0a Calcineurin Inhibitor Minimization in the Symphony Study: Observational Results 3 Years after Transplantation.
264 1b Elsevier BV,c 2009
520 a The Symphony study showed that at 1 year posttransplant, a regimen based on daclizumab induction, 2 g mycophenolate mofetil (MMF), low-dose tacrolimus and steroids resulted in better renal function and lower acute rejection and graft loss rates compared with three other regimens: two with low-doses of cyclosporine or sirolimus instead of tacrolimus and one with no induction and standard cyclosporine dosage. This is an observational follow-up for 2 additional years with the same endpoints as the core study. Overall, 958 patients participated in the follow-up. During the study, many patients changed their immunosuppressive regimen (e.g. switched from sirolimus to tacrolimus), but the vast majority (95%) remained on MMF. During the follow-up, renal function remained stable (mean change: -0.6 ml/min), and rates of death, graft loss and acute rejection were low (all about 1% per year). The MMF and low-dose tacrolimus arm continued to have the highest GFR (68.6 +/- 23.8 ml/min vs. 65.9 +/- 26.2 ml/min in the standard-dose cyclosporine, 64.0 +/- 23.1 ml/min in the low-dose cyclosporine and 65.3 +/- 26.2 ml/min in the low-dose sirolimus arm), but the difference with the other arms was not significant (p = 0.17 in an overall test and 0.077, 0.039 and 0.11, respectively, in pair-wise tests). The MMF and low-dose tacrolimus arm also had the highest graft survival rate, but with reduced differences between groups over time, and the least acute rejection rate. In the Symphony study, the largest ever prospective study in de novo kidney transplantation, over 3 years, daclizumab induction, MMF, steroids and low-dose tacrolimus proved highly efficacious, without the negative effects on renal function commonly reported for standard CNI regimens.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng
7001 a Bernasconi, C4 aut
7001 a Tedesco-Silva, H4 aut
7001 a Vítko, S4 aut
7001 a Hugo, C4 aut
7001 a Demirbas, A4 aut
7001 a Reyes Acevedo, R4 aut
7001 a Grinyó, J4 aut
7001 a Frei, U4 aut
7001 a Vanrenterghem, Y4 aut
7001 a Daloze, P4 aut
7001 a Halloran, P4 aut
7102 a Enheten för forskning kring njurfunktion och njursjukdomb Kirurgi4 org
7730 t American Journal of Transplantationd : Elsevier BVg 9, s. 1876-1885q 9<1876-1885x 1600-6135
8564 u http://www.ncbi.nlm.nih.gov/pubmed/19563339?dopt=Abstracty FULLTEXT
8564 u http://dx.doi.org/10.1111/j.1600-6143.2009.02726.xy FULLTEXT
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-6143.2009.02726.x
8564 8u https://lup.lub.lu.se/record/1453535
8564 8u https://doi.org/10.1111/j.1600-6143.2009.02726.x

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