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Metabolic syndrome ...
Metabolic syndrome across Europe: Different clusters of risk factors
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Scuteri, Angelo (author)
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Laurent, Stephane (author)
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Cucca, Francesco (author)
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Cockcroft, John (author)
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Cunha, Pedro Guimaraes (author)
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Rodriguez Manas, Leocadio (author)
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Raso, Francesco U. Mattace (author)
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Muiesan, Maria Lorenza (author)
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Ryliskyte, Ligita (author)
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Rietzschel, Ernst (author)
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Strait, James (author)
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Vlachopoulos, Charalambos (author)
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Volzke, Henry (author)
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Lakatta, Edward G. (author)
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- Nilsson, Peter (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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(creator_code:org_t)
- 2014-03-19
- 2015
- English.
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In: European Journal of Preventive Cardiology. - : Oxford University Press (OUP). - 2047-4881 .- 2047-4873. ; 22:4, s. 486-491
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http://dx.doi.org/10...
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https://europepmc.or...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Background: Metabolic syndrome (MetS) remains a controversial entity. Specific clusters of MetS components - rather than MetS per se - are associated with accelerated arterial ageing and with cardiovascular (CV) events. To investigate whether the distribution of clusters of MetS components differed cross-culturally, we studied 34,821 subjects from 12 cohorts from 10 European countries and one cohort from the USA in the MARE (Metabolic syndrome and Arteries REsearch) Consortium. Methods: In accordance with the ATP III criteria, MetS was defined as an alteration three or more of the following five components: elevated glucose (G), fasting glucose >= 110 mg/dl; low HDL cholesterol, <40mg/dl for men or <50 mg/dl for women; high triglycerides (T), >= 150 mg/dl; elevated blood pressure (B), >= 130/ >= 85 mmHg; abdominal obesity (W), waist circumference >102 cm for men or >88 cm for women. Results: MetS had a 24.3% prevalence (8468 subjects: 23.9% in men vs. 24.6% in women, p < 0.001) with an age-associated increase in its prevalence in all the cohorts. The age-adjusted prevalence of the clusters of MetS components previously associated with greater arterial and CV burden differed across countries (p < 0.0001) and in men and women (p < 0.0001). In details, the cluster TBW was observed in 12% of the subjects with MetS, but was far more common in the cohorts from the UK (32.3%), Sardinia in Italy (19.6%), and Germany (18.5%) and less prevalent in the cohorts from Sweden (1.2%), Spain (2.6%), and the USA (2.5%). The cluster GBW accounted for 12.7% of subjects with MetS with higher occurrence in Southern Europe (Italy, Spain, and Portugal: 31.4, 18.4, and 17.1% respectively) and in Belgium (20.4%), than in Northern Europe (Germany, Sweden, and Lithuania: 7.6, 9.4, and 9.6% respectively). Conclusions: The analysis of the distribution of MetS suggested that what follows under the common definition of MetS is not a unique entity rather a constellation of cluster of MetS components, likely selectively risky for CV disease, whose occurrence differs across countries.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Blood pressure
- epidemiology
- Europe
- glucose
- HDL cholesterol
- metabolic syndrome
- triglycerides
- waist circumference
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Scuteri, Angelo
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Laurent, Stephan ...
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Cucca, Francesco
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Cockcroft, John
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Cunha, Pedro Gui ...
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Rodriguez Manas, ...
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show more...
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Raso, Francesco ...
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Muiesan, Maria L ...
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Ryliskyte, Ligit ...
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Rietzschel, Erns ...
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Strait, James
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Vlachopoulos, Ch ...
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Volzke, Henry
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Lakatta, Edward ...
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Nilsson, Peter
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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European Journal ...
- By the university
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Lund University