WFRF:(Wallentin Lars C. 1943 )
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 15152naa a2203853 4500 | |
| 001 | oai:DiVA.org:umu-157574 | |
| 003 | SwePub | |
| 008 | 190401s2019 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:uu-379344 | |
| 009 | oai:lup.lub.lu.se:e480e762-4ec0-490f-8de5-8201f81cca66 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1575742 URI |
| 024 | 7 | a https://doi.org/10.1038/s41588-018-0334-22 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3793442 URI |
| 024 | 7 | a https://lup.lub.lu.se/record/e480e762-4ec0-490f-8de5-8201f81cca662 URI |
| 040 | a (SwePub)umud (SwePub)uud (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Justice, Anne E.u University of North Carolina,Geisinger Health System4 aut |
| 245 | 1 0 | a Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution |
| 264 | c 2019-02-18 | |
| 264 | 1 | b Nature Publishing Group,c 2019 |
| 338 | a print2 rdacarrier | |
| 500 | a For complete list of authors see http://dx.doi.org/10.1038/s41588-018-0334-2 | |
| 520 | a Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF >= 5%) and nine low-frequency or rare (MAF < 5%) coding novel variants. Pathway/gene set enrichment analyses identified lipid particle, adiponectin, abnormal white adipose tissue physiology and bone development and morphology as important contributors to fat distribution, while cross-trait associations highlight cardiometabolic traits. In functional follow-up analyses, specifically in Drosophila RNAi-knockdowns, we observed a significant increase in the total body triglyceride levels for two genes (DNAH10 and PLXND1). We implicate novel genes in fat distribution, stressing the importance of interrogating low-frequency and protein-coding variants. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 700 | 1 | a Karaderi, Tugce4 aut |
| 700 | 1 | a Highland, Heather M.4 aut |
| 700 | 1 | a Lind, Larsu Uppsala universitet,Klinisk epidemiologi4 aut0 (Swepub:uu)larslind |
| 700 | 1 | a Graff, Mariaelisa4 aut |
| 700 | 1 | a Lu, Yingchang4 aut |
| 700 | 1 | a Turcot, Valerie4 aut |
| 700 | 1 | a Auer, Paul L.4 aut |
| 700 | 1 | a Fine, Rebecca S.4 aut |
| 700 | 1 | a Guo, Xiuqing4 aut |
| 700 | 1 | a Schurmann, Claudia4 aut |
| 700 | 1 | a Lempradl, Adelheid4 aut |
| 700 | 1 | a Marouli, Eirini4 aut |
| 700 | 1 | a Mahajan, Anubha4 aut |
| 700 | 1 | a Winkler, Thomas W.4 aut |
| 700 | 1 | a Locke, Adam E.4 aut |
| 700 | 1 | a Medina-Gomez, Carolina4 aut |
| 700 | 1 | a Esko, Tonu4 aut |
| 700 | 1 | a Vedantam, Sailaja4 aut |
| 700 | 1 | a Giri, Ayush4 aut |
| 700 | 1 | a Lo, Ken Sin4 aut |
| 700 | 1 | a Alfred, Tamuno4 aut |
| 700 | 1 | a Mudgal, Poorva4 aut |
| 700 | 1 | a Ng, Maggie C. Y.4 aut |
| 700 | 1 | a Heard-Costa, Nancy L.4 aut |
| 700 | 1 | a Feitosa, Mary F.4 aut |
| 700 | 1 | a Manning, Alisa K.4 aut |
| 700 | 1 | a Willems, Sara M.4 aut |
| 700 | 1 | a Sivapalaratnam, Suthesh4 aut |
| 700 | 1 | a Abecasis, Goncalo4 aut |
| 700 | 1 | a Alam, Dewan S.4 aut |
| 700 | 1 | a Allison, Matthew4 aut |
| 700 | 1 | a Amouyel, Philippe4 aut |
| 700 | 1 | a Arzumanyanm, Zorayr4 aut |
| 700 | 1 | a Balkau, Beverley4 aut |
| 700 | 1 | a Bastarache, Lisa4 aut |
| 700 | 1 | a Bergmann, Sven4 aut |
| 700 | 1 | a Bielak, Lawrence F.4 aut |
| 700 | 1 | a Blueher, Matthias4 aut |
| 700 | 1 | a Boehnke, Michael4 aut |
| 700 | 1 | a Boeing, Heiner4 aut |
| 700 | 1 | a Boerwinkle, Eric4 aut |
| 700 | 1 | a Boeger, Carsten A.4 aut |
| 700 | 1 | a Bork-Jensen, Jette4 aut |
| 700 | 1 | a Bottinger, Erwin P.4 aut |
| 700 | 1 | a Bowden, Donald W.4 aut |
| 700 | 1 | a Brandslund, Ivan4 aut |
| 700 | 1 | a Broer, Linda4 aut |
| 700 | 1 | a Burt, Amber A.4 aut |
| 700 | 1 | a Butterworth, Adam S.4 aut |
| 700 | 1 | a Caulfield, Markj4 aut |
| 700 | 1 | a Cesana, Giancarlo4 aut |
| 700 | 1 | a Chambers, John C.4 aut |
| 700 | 1 | a Chasman, Daniel, I4 aut |
| 700 | 1 | a Chen, Yii-Der Ida4 aut |
| 700 | 1 | a Chowdhury, Rajiv4 aut |
| 700 | 1 | a Christensen, Cramer4 aut |
| 700 | 1 | a Chu, Audreyy4 aut |
| 700 | 1 | a Collins, Francis S.4 aut |
| 700 | 1 | a Cook, James P.4 aut |
| 700 | 1 | a Cox, Amanda J.4 aut |
| 700 | 1 | a Crosslin, David S.4 aut |
| 700 | 1 | a Danesh, John4 aut |
| 700 | 1 | a de Bakker, Paul I. W.4 aut |
| 700 | 1 | a de Denus, Simon4 aut |
| 700 | 1 | a de Mutsert, Renee4 aut |
| 700 | 1 | a Dedoussis, George4 aut |
| 700 | 1 | a Demerath, Ellen W.4 aut |
| 700 | 1 | a Dennis, Joe G.4 aut |
| 700 | 1 | a Denny, Josh C.4 aut |
| 700 | 1 | a Di Angelantonio, Emanuele4 aut |
| 700 | 1 | a Doerr, Marcus4 aut |
| 700 | 1 | a Drenos, Fotios4 aut |
| 700 | 1 | a Dube, Marie-Pierre4 aut |
| 700 | 1 | a Dunning, Alison M.4 aut |
| 700 | 1 | a Easton, Douglas F.4 aut |
| 700 | 1 | a Elliott, Paul4 aut |
| 700 | 1 | a Evangelou, Evangelosu University of North Carolina4 aut |
| 700 | 1 | a Farmaki, Aliki-Eleni4 aut |
| 700 | 1 | a Feng, Shuang4 aut |
| 700 | 1 | a Ferrannini, Ele4 aut |
| 700 | 1 | a Ferrieres, Jean4 aut |
| 700 | 1 | a Florez, Jose C.4 aut |
| 700 | 1 | a Fornage, Myriam4 aut |
| 700 | 1 | a Fox, Caroline S.4 aut |
| 700 | 1 | a Franks, Paul W.u Umeå University,Lund University,Lunds universitet,Umeå universitet,Avdelningen för medicin,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmo, Sweden; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-plf |
| 700 | 1 | a Friedrich, Nele4 aut |
| 700 | 1 | a Gan, Wei4 aut |
| 700 | 1 | a Gandin, Ilaria4 aut |
| 700 | 1 | a Gasparini, Paolo4 aut |
| 700 | 1 | a Giedraitis, Vilmantasu Uppsala universitet,Geriatrik4 aut0 (Swepub:uu)vigie517 |
| 700 | 1 | a Girotto, Giorgia4 aut |
| 700 | 1 | a Gorski, Mathias4 aut |
| 700 | 1 | a Grallert, Harald4 aut |
| 700 | 1 | a Grarup, Niels4 aut |
| 700 | 1 | a Groves, Megan L.4 aut |
| 700 | 1 | a Gustafsson, Stefanu Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi4 aut0 (Swepub:uu)stegu732 |
| 700 | 1 | a Haessler, Jeff4 aut |
| 700 | 1 | a Hansen, Torben4 aut |
| 700 | 1 | a Hattersley, Andrew T.4 aut |
| 700 | 1 | a Hayward, Caroline4 aut |
| 700 | 1 | a Heid, Iris M.4 aut |
| 700 | 1 | a Holmen, Oddgeir L.4 aut |
| 700 | 1 | a Hovingh, G. Kees4 aut |
| 700 | 1 | a Howson, Joanna M. M.4 aut |
| 700 | 1 | a Hu, Yao4 aut |
| 700 | 1 | a Hung, Yi-Jen4 aut |
| 700 | 1 | a Hveem, Kristian4 aut |
| 700 | 1 | a Ikram, M. Arfan4 aut |
| 700 | 1 | a Ingelsson, Erik,d 1975-u Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA4 aut0 (Swepub:uu)ering425 |
| 700 | 1 | a Jackson, Anne U.4 aut |
| 700 | 1 | a Jarvik, Gail P.4 aut |
| 700 | 1 | a Jia, Yucheng4 aut |
| 700 | 1 | a Jorgensen, Torben4 aut |
| 700 | 1 | a Jousilahti, Pekka4 aut |
| 700 | 1 | a Justesen, Johanne M.4 aut |
| 700 | 1 | a Kahali, Bratati4 aut |
| 700 | 1 | a Karaleftheri, Maria4 aut |
| 700 | 1 | a Kardia, Sharon L. R.4 aut |
| 700 | 1 | a Karpe, Fredrik4 aut |
| 700 | 1 | a Kee, Frank4 aut |
| 700 | 1 | a Kitajima, Hidetoshi4 aut |
| 700 | 1 | a Komulainen, Pirjo4 aut |
| 700 | 1 | a Kooner, Jaspal S.4 aut |
| 700 | 1 | a Kovacs, Peter4 aut |
| 700 | 1 | a Kraemer, Bernhard K.4 aut |
| 700 | 1 | a Kuulasmaa, Kari4 aut |
| 700 | 1 | a Kuusisto, Johanna4 aut |
| 700 | 1 | a Laakso, Markku4 aut |
| 700 | 1 | a Lakka, Timo A.4 aut |
| 700 | 1 | a Lamparter, David4 aut |
| 700 | 1 | a La Nge, Leslie A.4 aut |
| 700 | 1 | a Langenberg, Claudia4 aut |
| 700 | 1 | a Larson, Eric B.4 aut |
| 700 | 1 | a Lee, Nanette R.4 aut |
| 700 | 1 | a Lee, Wen-Jane4 aut |
| 700 | 1 | a Lehtimaeki, Terho4 aut |
| 700 | 1 | a Lewis, Cora E.4 aut |
| 700 | 1 | a Li, Huaixing4 aut |
| 700 | 1 | a Li, Jin4 aut |
| 700 | 1 | a Lin, Li-An4 aut |
| 700 | 1 | a Lin, Xu4 aut |
| 700 | 1 | a Lind, Lars4 aut |
| 700 | 1 | a Lindstroem, Jaana4 aut |
| 700 | 1 | a Linneberg, Allan4 aut |
| 700 | 1 | a Liu, Ching-Ti4 aut |
| 700 | 1 | a Liu, Dajiang J.4 aut |
| 700 | 1 | a Luan, Jian'an4 aut |
| 700 | 1 | a Lyytikainen, Leo-Pekka4 aut |
| 700 | 1 | a MacGregor, Stuart4 aut |
| 700 | 1 | a Magi, Reedik4 aut |
| 700 | 1 | a Mannisto, Satu4 aut |
| 700 | 1 | a Marenne, Gaelle4 aut |
| 700 | 1 | a Marten, Jonathan4 aut |
| 700 | 1 | a Mascal, Nicholas G. D.4 aut |
| 700 | 1 | a McCarthy, Mark, I4 aut |
| 700 | 1 | a Meidtner, Karina4 aut |
| 700 | 1 | a Mihailov, Evelin4 aut |
| 700 | 1 | a Moilanen, Leena4 aut |
| 700 | 1 | a Moitry, Marieu University of Oxford4 aut |
| 700 | 1 | a Mook-Kanamori, Dennis O.4 aut |
| 700 | 1 | a Morgan, Anna4 aut |
| 700 | 1 | a Morris, Andrew P.4 aut |
| 700 | 1 | a Mueller-Nurasyid, Martina4 aut |
| 700 | 1 | a Munroe, Patricia B.4 aut |
| 700 | 1 | a Narisu, Narisu4 aut |
| 700 | 1 | a Nelson, Christopher P.4 aut |
| 700 | 1 | a Neville, Matt4 aut |
| 700 | 1 | a Ntalla, Ioanna4 aut |
| 700 | 1 | a Owen, Katharine R.4 aut |
| 700 | 1 | a Pedersen, Oluf4 aut |
| 700 | 1 | a Peloso, Gina M.4 aut |
| 700 | 1 | a Pennell, Craig E.4 aut |
| 700 | 1 | a Perola, Markus4 aut |
| 700 | 1 | a James, A.4 aut |
| 700 | 1 | a Perry, John R. B.4 aut |
| 700 | 1 | a Pers, Tune H.4 aut |
| 700 | 1 | a Ewing, Ailith4 aut |
| 700 | 1 | a Polasek, Ozren4 aut |
| 700 | 1 | a Rasheed, Asif4 aut |
| 700 | 1 | a Raulerson, Chelsea K.4 aut |
| 700 | 1 | a Rauramaa, Rainer4 aut |
| 700 | 1 | a Reilly, Dermot F.4 aut |
| 700 | 1 | a Reiner, Alex P.4 aut |
| 700 | 1 | a Ridker, Paul M.4 aut |
| 700 | 1 | a Rivas, Manuel A.4 aut |
| 700 | 1 | a Robertson, Neil R.4 aut |
| 700 | 1 | a Robino, Antonietta4 aut |
| 700 | 1 | a Rudan, Igor4 aut |
| 700 | 1 | a Ruth, Katherine S.4 aut |
| 700 | 1 | a Saleheen, Danish4 aut |
| 700 | 1 | a Salomaa, Veikko4 aut |
| 700 | 1 | a Samani, Nilesh J.4 aut |
| 700 | 1 | a Schreiner, Pamela J.4 aut |
| 700 | 1 | a Schulze, Matthias B.4 aut |
| 700 | 1 | a Scott, Robert A.4 aut |
| 700 | 1 | a Segura-Lepe, Marcelo4 aut |
| 700 | 1 | a Sim, Xueling4 aut |
| 700 | 1 | a Slater, Andrew J.4 aut |
| 700 | 1 | a Small, Kerrin S.4 aut |
| 700 | 1 | a Smith, Blair H.4 aut |
| 700 | 1 | a Smith, Jennifer A.4 aut |
| 700 | 1 | a Southam, Lorraine4 aut |
| 700 | 1 | a Spector, Timothy D.4 aut |
| 700 | 1 | a Speliotes, Elizabeth K.4 aut |
| 700 | 1 | a Stefansson, Kari4 aut |
| 700 | 1 | a Steinthorsdottir, Valgerdur4 aut |
| 700 | 1 | a Stirrups, Kathleen E.4 aut |
| 700 | 1 | a Strauch, Konstantin4 aut |
| 700 | 1 | a Stringham, Heather M.4 aut |
| 700 | 1 | a Stumvoll, Michael4 aut |
| 700 | 1 | a Sun, Liang4 aut |
| 700 | 1 | a Surendran, Praveen4 aut |
| 700 | 1 | a Swart, Karin M. A.4 aut |
| 700 | 1 | a Tardif, Jean-Claude4 aut |
| 700 | 1 | a Taylor, Kent D.4 aut |
| 700 | 1 | a Teumer, Alexander4 aut |
| 700 | 1 | a Thompson, Deborah J.4 aut |
| 700 | 1 | a Thorleifsson, Gudmar4 aut |
| 700 | 1 | a Thorsteinsdottir, Unnur4 aut |
| 700 | 1 | a Thuesen, Betina H.4 aut |
| 700 | 1 | a Toenjes, Anke4 aut |
| 700 | 1 | a Torres, Mina4 aut |
| 700 | 1 | a Tsafantakis, Emmanouil4 aut |
| 700 | 1 | a Tuomilehto, Jaakko4 aut |
| 700 | 1 | a Uitterlinden, Andre G.4 aut |
| 700 | 1 | a Uusitupa, Matti4 aut |
| 700 | 1 | a van Duijn, Cornelia M.4 aut |
| 700 | 1 | a Vanhala, Mauno4 aut |
| 700 | 1 | a Varma, Rohit4 aut |
| 700 | 1 | a Vermeulen, Sita H.4 aut |
| 700 | 1 | a Vestergaard, Henrik4 aut |
| 700 | 1 | a Vitart, Veronique4 aut |
| 700 | 1 | a Vogt, Thomas F.4 aut |
| 700 | 1 | a Vuckovic, Dragana4 aut |
| 700 | 1 | a Wagenknecht, Lynne E.4 aut |
| 700 | 1 | a Walker, Mark4 aut |
| 700 | 1 | a Wallentin, Lars,d 1943-u Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)larswall |
| 700 | 1 | a Wang, Feijie4 aut |
| 700 | 1 | a Wang, Carol A.4 aut |
| 700 | 1 | a Wang, Shuai4 aut |
| 700 | 1 | a Wareham, N. Icholas J.4 aut |
| 700 | 1 | a Warren, Helen R.4 aut |
| 700 | 1 | a Waterworth, Dawn M.4 aut |
| 700 | 1 | a Wessel, Jennifer4 aut |
| 700 | 1 | a White, Harvey D.4 aut |
| 700 | 1 | a Willer, Cristen J.4 aut |
| 700 | 1 | a Wilson, James G.4 aut |
| 700 | 1 | a Wood, Andrew R.4 aut |
| 700 | 1 | a Wu, Ying4 aut |
| 700 | 1 | a Yaghootkar, Hanieh4 aut |
| 700 | 1 | a Yao, Jie4 aut |
| 700 | 1 | a Verges-Armstrong, Laura M.4 aut |
| 700 | 1 | a Young, Robin4 aut |
| 700 | 1 | a Zeggini, Eleftheria4 aut |
| 700 | 1 | a Zhan, Xiaowei4 aut |
| 700 | 1 | a Zhang, Weihua4 aut |
| 700 | 1 | a Zhao, Jing Hua4 aut |
| 700 | 1 | a Zhao, Wei4 aut |
| 700 | 1 | a Zheng, He4 aut |
| 700 | 1 | a Zhou, Wei4 aut |
| 700 | 1 | a Zillikens, M. Carola4 aut |
| 700 | 1 | a Rivadeneira, Fernando4 aut |
| 700 | 1 | a Borecki, Ingrid B.4 aut |
| 700 | 1 | a Pospisilik, J. Andrew4 aut |
| 700 | 1 | a Deloukas, Panos4 aut |
| 700 | 1 | a Frayling, Timothy M.4 aut |
| 700 | 1 | a Lettre, Guillaume4 aut |
| 700 | 1 | a Mohlke, Karen L.4 aut |
| 700 | 1 | a Rotter, Jerome, I4 aut |
| 700 | 1 | a Kutalik, Zoltan4 aut |
| 700 | 1 | a Hirschhorn, Joel N.4 aut |
| 700 | 1 | a Cupples, L. Adrienne4 aut |
| 700 | 1 | a Loos, Ruth J. F.4 aut |
| 700 | 1 | a North, Kari E.4 aut |
| 700 | 1 | a Lindgren, Cecilia M.4 aut |
| 700 | 1 | a O'Connell, Jeffrey R.4 aut |
| 700 | 1 | a Raitakari, Olli T.4 aut |
| 700 | 1 | a Lange, Leslie A.4 aut |
| 700 | 1 | a Uitterlinden, Andr G.4 aut |
| 700 | 1 | a Grove, Megan L.4 aut |
| 700 | 1 | a Masca, Nicholas G. D.4 aut |
| 700 | 1 | a Luan, Jianan4 aut |
| 700 | 1 | a Wareham, Nicholas J.4 aut |
| 700 | 1 | a Esko, Tnu4 aut |
| 700 | 1 | a De Bakker, Paul Iw4 aut |
| 700 | 1 | a Caulfield, Mark J.4 aut |
| 700 | 1 | a Mller-Nurasyid, Martina4 aut |
| 710 | 2 | a University of North Carolinab Geisinger Health System4 org |
| 710 | 2 | a et al. |
| 773 | 0 | t Nature Geneticsd : Nature Publishing Groupg 51:3, s. 452-469q 51:3<452-469x 1061-4036x 1546-1718 |
| 856 | 4 | u https://api.research-repository.uwa.edu.au/ws/files/69275631/AAM_Protein_coding_variants_implicates.pdf |
| 856 | 4 | u http://dx.doi.org/10.1038/s41588-018-0334-2y FULLTEXT |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-157574 |
| 856 | 4 8 | u https://doi.org/10.1038/s41588-018-0334-2 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-379344 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/e480e762-4ec0-490f-8de5-8201f81cca66 |
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