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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04647naa a2201057 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:140656239 | |
| 003 | SwePub | |
| 008 | 240701s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1406562392 URI |
| 024 | 7 | a https://doi.org/10.1038/s41598-019-42087-z2 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Edlmann, E4 aut |
| 245 | 1 0 | a Dex-CSDH randomised, placebo-controlled trial of dexamethasone for chronic subdural haematoma: report of the internal pilot phase |
| 264 | c 2019-04-10 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2019 |
| 520 | a The Dex-CSDH trial is a randomised, double-blind, placebo-controlled trial of dexamethasone for patients with a symptomatic chronic subdural haematoma. The trial commenced with an internal pilot, whose primary objective was to assess the feasibility of multi-centre recruitment. Primary outcome data collection and safety were also assessed, whilst maintaining blinding. We aimed to recruit 100 patients from United Kingdom Neurosurgical Units within 12 months. Trial participants were randomised to a 2-week course of dexamethasone or placebo in addition to receiving standard care (which could include surgery). The primary outcome measure of the trial is the modified Rankin Scale at 6 months. This pilot recruited ahead of target; 100 patients were recruited within nine months of commencement. 47% of screened patients consented to recruitment. The primary outcome measure was collected in 98% of patients. No safety concerns were raised by the independent data monitoring and ethics committee and only five patients were withdrawn from drug treatment. Pilot trial data can inform on the design and resource provision for substantive trials. This internal pilot was successful in determining recruitment feasibility. Excellent follow-up rates were achieved and exploratory outcome measures were added to increase the scientific value of the trial. | |
| 700 | 1 | a Thelin, EPu Karolinska Institutet4 aut |
| 700 | 1 | a Caldwell, K4 aut |
| 700 | 1 | a Turner, C4 aut |
| 700 | 1 | a Whitfield, P4 aut |
| 700 | 1 | a Bulters, D4 aut |
| 700 | 1 | a Holton, P4 aut |
| 700 | 1 | a Suttner, N4 aut |
| 700 | 1 | a Owusu-Agyemang, K4 aut |
| 700 | 1 | a Al-Tamimi, YZ4 aut |
| 700 | 1 | a Gatt, D4 aut |
| 700 | 1 | a Thomson, S4 aut |
| 700 | 1 | a Anderson, IA4 aut |
| 700 | 1 | a Richards, O4 aut |
| 700 | 1 | a Gherle, M4 aut |
| 700 | 1 | a Toman, E4 aut |
| 700 | 1 | a Nandi, D4 aut |
| 700 | 1 | a Kane, P4 aut |
| 700 | 1 | a Pantaleo, B4 aut |
| 700 | 1 | a Davis-Wilkie, C4 aut |
| 700 | 1 | a Tarantino, S4 aut |
| 700 | 1 | a Barton, G4 aut |
| 700 | 1 | a Marcus, HJ4 aut |
| 700 | 1 | a Chari, A4 aut |
| 700 | 1 | a Belli, A4 aut |
| 700 | 1 | a Bond, S4 aut |
| 700 | 1 | a Gafoor, R4 aut |
| 700 | 1 | a Dawson, S4 aut |
| 700 | 1 | a Whitehead, L4 aut |
| 700 | 1 | a Brennan, P4 aut |
| 700 | 1 | a Wilkinson, I4 aut |
| 700 | 1 | a Kolias, AG4 aut |
| 700 | 1 | a Hutchinson, PJA4 aut |
| 700 | 1 | a Badran, K4 aut |
| 700 | 1 | a Coulter, I4 aut |
| 700 | 1 | a Gallagher, MJ4 aut |
| 700 | 1 | a Hogg, FRA4 aut |
| 700 | 1 | a Pringle, C4 aut |
| 700 | 1 | a Razak, A4 aut |
| 700 | 1 | a Soleiman, H4 aut |
| 700 | 1 | a Piper, R4 aut |
| 700 | 1 | a Vintu, M4 aut |
| 700 | 1 | a Wahba, A4 aut |
| 700 | 1 | a Wiggins, A4 aut |
| 700 | 1 | a Yakoub, KM4 aut |
| 700 | 1 | a Zaben, M4 aut |
| 700 | 1 | a Zolnourian, A4 aut |
| 700 | 1 | a Bodkin, P4 aut |
| 700 | 1 | a Cirstea, E4 aut |
| 700 | 1 | a Critchley, G4 aut |
| 700 | 1 | a Eglinton, C4 aut |
| 700 | 1 | a Finlay, L4 aut |
| 700 | 1 | a Georgieva, D4 aut |
| 700 | 1 | a Gurusinghe, N4 aut |
| 700 | 1 | a Haliasos, N4 aut |
| 700 | 1 | a Holliman, D4 aut |
| 700 | 1 | a Hossain-Ibrahim, K4 aut |
| 700 | 1 | a Hussain, M4 aut |
| 700 | 1 | a Kandasamy, J4 aut |
| 700 | 1 | a Kambafwile, M4 aut |
| 700 | 1 | a Nannapaneni, R4 aut |
| 700 | 1 | a de Gordoa, LOR4 aut |
| 700 | 1 | a Papadopoulos, MC4 aut |
| 700 | 1 | a Paraskevopoulos, D4 aut |
| 700 | 1 | a Patel, J4 aut |
| 700 | 1 | a Prasad, KSM4 aut |
| 700 | 1 | a Tzerakis, N4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Scientific reportsd : Springer Science and Business Media LLCg 9:1, s. 5885-q 9:1<5885-x 2045-2322 |
| 856 | 4 | u https://www.nature.com/articles/s41598-019-42087-z.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:140656239 |
| 856 | 4 8 | u https://doi.org/10.1038/s41598-019-42087-z |
Hitta mer i SwePub
- Av författaren/redakt...
- Edlmann, E
- Thelin, EP
- Caldwell, K
- Turner, C
- Whitfield, P
- Bulters, D
- visa fler...
- Holton, P
- Suttner, N
- Owusu-Agyemang, ...
- Al-Tamimi, YZ
- Gatt, D
- Thomson, S
- Anderson, IA
- Richards, O
- Gherle, M
- Toman, E
- Nandi, D
- Kane, P
- Pantaleo, B
- Davis-Wilkie, C
- Tarantino, S
- Barton, G
- Marcus, HJ
- Chari, A
- Belli, A
- Bond, S
- Gafoor, R
- Dawson, S
- Whitehead, L
- Brennan, P
- Wilkinson, I
- Kolias, AG
- Hutchinson, PJA
- Badran, K
- Coulter, I
- Gallagher, MJ
- Hogg, FRA
- Pringle, C
- Razak, A
- Soleiman, H
- Piper, R
- Vintu, M
- Wahba, A
- Wiggins, A
- Yakoub, KM
- Zaben, M
- Zolnourian, A
- Bodkin, P
- Cirstea, E
- Critchley, G
- Eglinton, C
- Finlay, L
- Georgieva, D
- Gurusinghe, N
- Haliasos, N
- Holliman, D
- Hossain-Ibrahim, ...
- Hussain, M
- Kandasamy, J
- Kambafwile, M
- Nannapaneni, R
- de Gordoa, LOR
- Papadopoulos, MC
- Paraskevopoulos, ...
- Patel, J
- Prasad, KSM
- Tzerakis, N
- visa färre...
- Artiklar i publikationen
- Scientific repor ...
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- Karolinska Institutet
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