Comparative Gut Microbiome Differences between Ferric Citrate and Calcium Carbonate Phosphate Binders in Patients with End-Stage Kidney Disease

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Comparative Gut Microbiome Differences between Ferric Citrate and Calcium Carbonate Phosphate Binders in Patients with End-Stage Kidney Disease

Wu, Ping-Hsun (författare): Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 807, Taiwan.;Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung 807, Taiwan.;Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 807, Taiwan.

Liu, Po-Yu (författare): Natl Taiwan Univ, Dept Internal Med, Coll Med, Taipei 106, Taiwan.

Chiu, Yi-Wen (författare): Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 807, Taiwan.;Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 807, Taiwan.;Kaohsiung Med Univ, Coll Med, Fac Renal Care, Kaohsiung 807, Taiwan.

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Hung, Wei-Chun (författare): Kaohsiung Med Univ, Dept Microbiol & Immunol, Kaohsiung 807, Taiwan.

Lin, Yi-Ting (författare): Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung 807, Taiwan.;Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 807, Taiwan.;Kaohsiung Med Univ Hosp, Dept Family Med, Kaohsiung 807, Taiwan.

Lin, Ting-Yun (författare): Tzu Chi Univ, Taipei Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Sch Med,Div Nephrol, Hualien 970, Taiwan.

Hung, Szu-Chun (författare): Tzu Chi Univ, Taipei Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Sch Med,Div Nephrol, Hualien 970, Taiwan.

Delicano, Rachel Ann (författare): Uppsala universitet,Ortopedi

Kuo, Mei-Chuan (författare): Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 807, Taiwan.;Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 807, Taiwan.;Kaohsiung Med Univ, Coll Med, Fac Renal Care, Kaohsiung 807, Taiwan.

Wu, Chun-Ying (författare): Natl Yang Ming Univ, Med Coll, Inst Biomed Informat, Taipei 112, Taiwan.;Taipei Vet Gen Hosp, Dept Med Res, Div Translat Res, Taipei 112, Taiwan.;China Med Univ, Dept Publ Hlth, Taichung 406, Taiwan.;Natl Hlth Res Inst, Natl Inst Canc Res, Miaoli 350, Taiwan.

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Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 807, Taiwan;Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung 807, Taiwan.;Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 807, Taiwan. Natl Taiwan Univ, Dept Internal Med, Coll Med, Taipei 106, Taiwan. (creator_code:org_t)

2020-12-20
2020
Engelska.
Ingår i: Microorganisms. - : MDPI. - 2076-2607. ; 8:12

Relaterad länk:: https://doi.org/10.3...; visa fler...; https://uu.diva-port... (primary) (Raw object); https://www.mdpi.com...; https://urn.kb.se/re...; https://doi.org/10.3...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Gut dysbiosis in patients with chronic kidney disease (CKD) may induce chronic inflammation and increase morbidity. Phosphate-binding agents, generally used in patients with CKD, may potentially change the composition of the gut microbiota. This study aimed to compare the microbiota composition in hemodialysis patients treated with ferric citrate or calcium carbonate. The stool microbiota was investigated in hemodialysis patients treated with ferric citrate (n = 8) and calcium carbonate (n = 46) using 16S rRNA gene amplicon sequencing profiling using linear discriminant analysis of effect size. Further predictive functional profiling of microbial communities was obtained with Tax4Fun in R. Hemodialysis patients treated with calcium carbonate had a significantly reduced microbial species diversity (Shannon index and Simpson index) and an increased microbial alteration ratio compared with patients treated with ferric citrate. A distinct microbial community structure was found in patients treated with ferric citrate, with an increased abundance of the Bacteroidetes phylum and a decreased abundance of the phylum Firmicutes. Members of the order Lactobacillales were enriched in patients treated with calcium carbonate, whereas taxa of the genera Ruminococcaceae UCG-004, Flavonifractor, and Cronobacter were enriched in patients treated with ferric citrate phosphate binder. In conclusion, Ferric citrate therapy results in a more diverse microbiome community compared to calcium carbonate therapy in hemodialysis patients with phosphate binder treatment. The gut microbiome reflects the phosphate binder choice in hemodialysis patients, further affecting the physiological environment in the gastrointestinal tract.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)

Nyckelord

microbiome
ferric citrate
calcium carbonate
phosphate binders
hemodialysis

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Av författaren/redakt...: Wu, Ping-Hsun; Liu, Po-Yu; Chiu, Yi-Wen; Hung, Wei-Chun; Lin, Yi-Ting; Lin, Ting-Yun; visa fler...; Hung, Szu-Chun; Delicano, Rachel ...; Kuo, Mei-Chuan; Wu, Chun-Ying; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Urologi och njur ...

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