WFRF:(Wu Jieying)
Sökning: WFRF:(Wu Jieying) > Probe for simultane...
Probe for simultaneous membrane and nucleus labeling in living cells and in vivo bioimaging using a two-photon absorption water-soluble Zn(II) terpyridine complex with a reduced pi-conjugation system
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- Tian, Xiaohe (författare)
- Anhui University, Peoples R China
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- Zhang, Qian (författare)
- Linköpings universitet,Ytors Fysik och Kemi,Tekniska fakulteten,Anhui University, Peoples R China
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- Zhang, Mingzhu (författare)
- Anhui University, Peoples R China
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- 2017
- 2017
- Engelska.
- Ingår i: Chemical Science. - : ROYAL SOC CHEMISTRY. - 2041-6520 .- 2041-6539. ; 8:1, s. 142-149
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Small, biocompatible and water-soluble molecules with high two-photon absorption (2PA) cross-section values (delta) are in high demand for specific bioimaging applications. Here, two novel terpyridine derivative ligands with donor-acceptor (D-A) (L1) and donor-pi-acceptor (D-pi-A) (L2) models, and their corresponding Zn(II) complexes are designed and characterized. It was found that the two-photon absorption cross section values (d) in the near-infrared region (NIR, about 800 nm) are significantly enhanced for complexes 1 and 2 compared to their free D-A type ligand L1, while those of complexes 3 and 4 were greatly decreased relative to their free ligand L2, thus confirming that the smaller ligand (D-A type) displays a suitable Turn-ON fluorescence pair for two-photon fluorescence microscopy (2PFM). Firstly, the potential of simultaneously labeling a live cell plasma membrane and nucleus using complex 1 is demonstrated. In addition, live larval and adult zebrafish incubated with an optimal concentration of 1 demonstrated clear brain uptake. Lastly and importantly, using such a probe to visualize the blood-brain- barrier (BBB) capillary endothelial cells and penetrate the BBB into the central nervous system (CNS) intravenously in a mouse model is also explored.
Ämnesord
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Publikations- och innehållstyp
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- art (ämneskategori)
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- Tian, Xiaohe
- Zhang, Qian
- Zhang, Mingzhu
- Uvdal, Kajsa
- Wang, Qin
- Chen, Junyang
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- Du, Wei
- Huang, Bei
- Wu, Jieying
- Tian, Yupeng
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- NATURVETENSKAP
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