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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004249naa a2200553 4500
001oai:lup.lub.lu.se:55676fdc-f539-432a-974c-fe40fef097d0
003SwePub
008160401s2010 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/16180342 URI
0247 a https://doi.org/10.1007/s10552-010-9510-02 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Poynter, Jenny N.4 aut
2451 0a Reproductive factors and risk of contralateral breast cancer by BRCA1 and BRCA2 mutation status: results from the WECARE study
264 c 2010-02-04
264 1b Springer Science and Business Media LLC,c 2010
520 a Reproductive factors, such as early age at menarche, late age at menopause, and nulliparity are known risk factors for breast cancer. Previously, we reported these factors to be associated with risk of developing contralateral breast cancer (CBC). In this study, we evaluated the association between these factors and CBC risk among BRCA1 and BRCA2 (BRCA1/2) mutation carriers and non-carriers. The WECARE Study is a population-based multi-center case-control study of 705 women with CBC (cases) and 1,397 women with unilateral breast cancer (controls). All participants were screened for BRCA1/2 mutations and 181 carriers were identified. Conditional logistic regression models were used to evaluate associations between reproductive factors and CBC for mutation carriers and non-carriers. None of the associations between reproductive factors and CBC risk differed between mutation carriers and non-carriers. The increase in risk with younger age at menarche and decrease in risk in women with more than two full-term pregnancies seen in non-carriers were not significantly different in carriers (adjusted RRs = 1.31, 95% CI 0.65-2.65 and 0.53, 95% CI 0.19-1.51, respectively). No significant associations between the other reproductive factors and CBC risk were observed in mutation carriers or non-carriers. For two reproductive factors previously shown to be associated with CBC risk, we observed similar associations for BRCA1/2 carriers. This suggests that reproductive variables that affect CBC risk may have similar effects in mutation carriers and non-carriers.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Reproductive factors
653 a Contralateral breast cancer
653 a BRCA1
653 a BRCA2
7001 a Langholz, Bryan4 aut
7001 a Largent, Joan4 aut
7001 a Mellemkjaer, Lene4 aut
7001 a Bernstein, Leslie4 aut
7001 a Malone, Kathleen E.4 aut
7001 a Lynch, Charles F.4 aut
7001 a Borg, Åkeu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-abo
7001 a Concannon, Patrick4 aut
7001 a Teraoka, Sharon N.4 aut
7001 a Xue, Shanyan4 aut
7001 a Diep, Anh T.4 aut
7001 a Törngren, Thereseu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-tsa
7001 a Begg, Colin B.4 aut
7001 a Capanu, Marinela4 aut
7001 a Haile, Robert W.4 aut
7001 a Bernstein, Jonine L.4 aut
7102 a Bröstcancer-genetikb Sektion I4 org
7730 t Cancer Causes and Controld : Springer Science and Business Media LLCg 21:6, s. 839-846q 21:6<839-846x 1573-7225x 0957-5243
8564 u http://www.ncbi.nlm.nih.gov/sites/pubmedy FULLTEXT
8564 u http://dx.doi.org/10.1007/s10552-010-9510-0y FULLTEXT
8564 u https://europepmc.org/articles/pmc2873079?pdf=render
8564 8u https://lup.lub.lu.se/record/1618034
8564 8u https://doi.org/10.1007/s10552-010-9510-0

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