Sökning: onr:"swepub:oai:lup.lub.lu.se:9576acab-ebc5-46a5-a989-604d22b34fe0" >
Fluctuations of the...
Fluctuations of the transcription factor ATML1 generate the pattern of giant cells in the Arabidopsis sepal
-
- Meyer, Heather M (författare)
- Cornell University
-
- Teles, José (författare)
- University of Cambridge
-
- Formosa-Jordan, Pau (författare)
- University of Cambridge
-
visa fler...
-
- Refahi, Yassin (författare)
- University of Cambridge
-
- San-Bento, Rita (författare)
- Reproduction et Développement des Plantes
-
- Ingram, Gwyneth (författare)
- Reproduction et Développement des Plantes
-
- Jönsson, Henrik (författare)
- Lund University,Lunds universitet,Beräkningsbiologi och biologisk fysik - Genomgår omorganisation,Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation,Naturvetenskapliga fakulteten,Computational Biology and Biological Physics - Undergoing reorganization,Department of Astronomy and Theoretical Physics - Undergoing reorganization,Faculty of Science,University of Cambridge
-
- Locke, James C.W. (författare)
- University of Cambridge
-
- Roeder, Adrienne H K (författare)
- Cornell University
-
visa färre...
-
(creator_code:org_t)
- 2017
- 2017
- Engelska.
-
Ingår i: eLife. - 2050-084X.
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://lup.lub.lu.s...
-
https://doi.org/10.7...
-
visa färre...
Abstract
Ämnesord
Stäng
- Multicellular development produces patterns of specialized cell types. Yet, it is often unclear how individual cells within a field of identical cells initiate the patterning process. Using live imaging, quantitative image analyses and modeling, we show that during Arabidopsis thaliana sepal development, fluctuations in the concentration of the transcription factor ATML1 pattern a field of identical epidermal cells to differentiate into giant cells interspersed between smaller cells. We find that ATML1 is expressed in all epidermal cells. However, its level fluctuates in each of these cells. If ATML1 levels surpass a threshold during the G2 phase of the cell cycle, the cell will likely enter a state of endoreduplication and become giant. Otherwise, the cell divides. Our results demonstrate a fluctuation-driven patterning mechanism for how cell fate decisions can be initiated through a random yet tightly regulated process.
Ämnesord
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
-
eLife
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas