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Sökning: WFRF:(Zafarmand Mohammad Hadi) > Enhanced liver fibr...

Enhanced liver fibrosis test for the non-invasive diagnosis of fibrosis in patients with NAFLD : A systematic review and meta-analysis

Vali, Yasaman (författare)
Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, University of Amsterdam, The Netherlands
Lee, Jenny (författare)
Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, University of Amsterdam, The Netherlands
Boursier, Jérôme (författare)
Hepato-Gastroenterology Department, Angers University Hospital, Angers, France; HIFIH Laboratory, UPRES EA3859, Angers University, Angers, France
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Spijker, René (författare)
Medical Library AMC, Amsterdam, the Netherlands; Cochrane Netherlands, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
Löffler, Jürgen (författare)
Novartis Pharma AG, Basel, Switzerland
Verheij, Joanne (författare)
Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands
Brosnan, M. Julia (författare)
Internal Medicine Research Unit, Pfizer Inc, Cambridge, MA, USA
Böcskei, Zsolt (författare)
Sanofi R&D, Translational Sciences Unit, Chilly Mazarin, France
Anstee, Quentin M. (författare)
The Newcastle Liver Research Group, Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK; Newcastle NIHR Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
Bossuyt, Patrick M. (författare)
Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, University of Amsterdam, The Netherlands
Zafarmand, Mohammad Hadi (författare)
Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, University of Amsterdam, The Netherlands
Pavlides, Michael (författare)
Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, UK; Translational Gastroenterology Unit, University of Oxford, UK; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust and the University of Oxford, Oxford, UK
Levick, Christina (författare)
Translational Gastroenterology Unit, University of Oxford, UK
Duffin, Kevin (författare)
Eli Lilly and Company Ltd (LLY), USA
Hyde, Craig (författare)
Pfizer Worldwide Research and Development (PFE), 1 Portland Square, Cambridge, USA
Bauer, Tim (författare)
SomaLogic, Inc. USA
Bedossa, Pierre (författare)
University Paris-Diderot, Pathology, Hôpital Beaujon, APHP (APHP), Paris, France
Leeming, Diana (författare)
Nordic Bioscience (NB), Denmark
Daly, Ann (författare)
Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
Hanf, Remy (författare)
Genfit SA, France
Ortiz, Pablo (författare)
OWL/metabolomics, One Way Liver S.L, Spain
Oresic, Matej, 1967- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper
Schuppan, Detlef (författare)
University Medical Center Mainz (UMCM), Germany
Hanauer, Guido (författare)
Takeda Development Center Europe, London, UK
Chen, Yu (författare)
Eli Lilly and Company Ltd (LLY), USA
Shumbayawonda, Elizabeth (författare)
Perspectum Diagnostics Ltd., Oxford, UK
Bjerring, Peter Nissen (författare)
Novo Nordisk, Bagsværd, Denmark
Zwinderman, Koos (författare)
Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, University of Amsterdam, The Netherlands
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 (creator_code:org_t)
Elsevier, 2020
2020
Engelska.
Ingår i: Journal of Hepatology. - : Elsevier. - 0168-8278 .- 1600-0641. ; 73:2, s. 252-262
Relaterad länk:
https://doi.org/10.1...
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http://www.journal-o...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Forskningsöversikt (refereegranskat)
Abstract Ämnesord
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  • BACKGROUND AND AIMS: The Enhanced Liver Fibrosis (ELF) test is a non-invasive biomarker, suggested as an appropriate test for advanced liver fibrosis in non-alcoholic fatty liver disease (NAFLD). This systematic review aimed to provide summary estimates of the accuracy of this test against biopsy.METHODS: In this systematic review, we searched MEDLINE, Embase, Web of Science and the Cochrane Library, for studies included NAFLD patients and undertook both liver biopsy as the reference standard and the ELF test. Two authors independently screened the references, extracted the data and assessed the quality of included studies. Due to the variation in reported thresholds, we used a multiple thresholds random effects model for meta-analysis (diagmeta R-package).RESULTS: The meta-analysis of 11 studies reporting advanced fibrosis and five studies reporting significant fibrosis showed sensitivity of >0.90 of the ELF test for excluding fibrosis at threshold of 7.7. However, as a diagnostic test at high thresholds, the test showed specificity and positive predictive value >0.80, only in very high-prevalence settings (>50%). Desiring specificity of 0.90 for advanced and significant fibrosis resulted in thresholds of 10.18 (sensitivity: 0.57) and 9.86 (sensitivity: 0.55), respectively.CONCLUSION: The ELF test showed high sensitivity but limited specificity to exclude advanced and significant fibrosis at low cutoffs. The diagnostic performance of the test at higher thresholds was found to be more limited in low prevalence settings. We conclude that clinicians should carefully consider the likely disease prevalence in their practice setting and adopt suitable test thresholds to achieve the desired test performance.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)

Nyckelord

Enhanced Liver Fibrosis Test
Fibrosis
Non-alcoholic Fatty Liver Disease
Non-alcoholic Steatohepatitis

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