WFRF:(Zhang Dongfeng)
Sökning: WFRF:(Zhang Dongfeng) > Heritability of Age...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03975naa a2200481 4500 | |
| 001 | oai:DiVA.org:su-167640 | |
| 003 | SwePub | |
| 008 | 190408s2019 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:140383785 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1676402 URI |
| 024 | 7 | a https://doi.org/10.1097/AUD.00000000000006102 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1403837852 URI |
| 040 | a (SwePub)sud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Duan, Haipingu Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Qingdao University School of Public Health, China; Qingdao Center for Disease Control and Prevention, China4 aut |
| 245 | 1 0 | a Heritability of Age-Related Hearing Loss in Middle-Aged and Elderly Chinese :b A Population-Based Twin Study |
| 264 | 1 | c 2019 |
| 338 | a print2 rdacarrier | |
| 520 | a Objectives: The heritability of age-related hearing loss has been studied mostly in developed countries. The authors aimed to estimate the heritability of better ear hearing level (BEHL), defined as hearing level of the better ear at a given frequency, and pure-tone averages at the middle (0.5, 1.0, and 2.0 kHz) and high (4.0, 8.0, and 12.5 kHz) frequencies among middle-aged and elderly Chinese twins, and to explore their genetic correlations.Design: This population-based twin study included 226 monozygotic and 132 dizygotic twin-pairs and 1 triplet (age range, 33 to 80 years; mean age, 51.55 years). Pure-tone air-conducted hearing thresholds in each ear were measured at the frequencies of 0.5, 1.0, 2.0, 4.0, 8.0, and 12.5 kHz with a diagnostic audiometer. Univariate and multivariate twin models were fitted to evaluate heritability and genetic correlations.Results: Our data showed a reverse J-shaped pattern of BEHLs at six frequencies by age and sex. Univariate analysis showed that the heritability of BEHLs at the frequencies between 2.0 and 12.5 kHz ranged from 47.08 to 54.20%, but the heritability at the frequencies of 0.5 and 1.0 kHz was 1.65% and 18.68%, respectively. The heritability of pure-tone average at the middle and high frequencies was 34.77% and 43.26%, respectively. Multivariate analysis showed significant genetic correlations among BEHLs at all six frequencies, with the correlation coefficients ranging from 0.48 to 0.83 at middle frequencies, and from 0.46 to 0.75 at high frequencies.Conclusions: This population-based twin study suggests that genetic factors are associated with age-related hearing loss at middle and high frequencies among middle-aged and elderly Chinese. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Oto-rhino-laryngologi0 (SwePub)302182 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Otorhinolaryngology0 (SwePub)302182 hsv//eng |
| 653 | a Age-related hearing loss | |
| 653 | a Better ear hearing level | |
| 653 | a Heritability | |
| 653 | a Pure-tone average | |
| 653 | a Twin study | |
| 700 | 1 | a Zhang, Dongfeng4 aut |
| 700 | 1 | a Liang, Yajunu Karolinska Institutet4 aut |
| 700 | 1 | a Xu, Chunshengu Karolinska Institutet4 aut |
| 700 | 1 | a Wu, Yili4 aut |
| 700 | 1 | a Tian, Xiaocao4 aut |
| 700 | 1 | a Pang, Zengchang4 aut |
| 700 | 1 | a Tan, Qihua4 aut |
| 700 | 1 | a Li, Shuxia4 aut |
| 700 | 1 | a Qiu, Chengxuanu Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 aut |
| 710 | 2 | a Stockholms universitetb Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 org |
| 773 | 0 | t Ear and Hearingg 40:2, s. 253-259q 40:2<253-259x 0196-0202x 1538-4667 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-167640 |
| 856 | 4 8 | u https://doi.org/10.1097/AUD.0000000000000610 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:140383785 |
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