Human Exposure and Elimination Kinetics of Chlorinated Polyfluoroalkyl Ether Sulfonic Acids (Cl-PFESAs)

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Fältnamn	Indikatorer	Metadata
000		03173naa a2200385 4500
001		oai:DiVA.org:su-128510
003		SwePub
008		160330s2016 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1285102 URI
024	7	a https://doi.org/10.1021/acs.est.5b058492 DOI
040		a (SwePub)su
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Shi, Yali4 aut
245	1 0	a Human Exposure and Elimination Kinetics of Chlorinated Polyfluoroalkyl Ether Sulfonic Acids (Cl-PFESAs)
264		c 2016-02-11
264	1	b American Chemical Society (ACS),c 2016
338		a print2 rdacarrier
520		a The incomplete mass-balance of organic fluorine in human serum indicates the existence of unknown per- and polyfluoroalkyl substances (PFASs) with persistent and bioaccumulative properties. Here we characterized human exposure and elimination kinetics of chlorinated polyfluoroalkyl ether sulfonic acids (Cl-PFESAs) in metal plating workers (n = 19), high fish consumers (n = 45), and background controls (n = 8). Cl-PFESAs were detected in >98% of the sampled individuals with serum concentrations ranging <0.019-5040 ng/mL. Statistically higher median serum levels were observed in high fish consumers (93.7 ng/mL) and metal plating workers (51.5 ng/mL) compared to the background control group (4.78 ng/mL) (Kruskal Wallis rank sum test, p < 0.01). Cl-PFESAs could account for 0.269 to 93.3% of Sigma PFASs in human serum indicating that this compound class may explain a substantial fraction of previously unidentified organic fluorine in the Chinese population. Estimated half-lives for renal clearance (median 280 years; range 7.1-4230 years) and total elimination (median 15.3 years; range 10.1-56.4 years) for the eight carbon Cl-PFESA suggest that this is the most biopersistent PFAS in humans reported to date. The apparent ubiquitous distribution and slow elimination kinetics in humans underscore the need for more research and regulatory actions on Cl-PFESAs and PFAS alternatives with similar chemical structures.
650	7	a TEKNIK OCH TEKNOLOGIERx Naturresursteknik0 (SwePub)2072 hsv//swe
650	7	a ENGINEERING AND TECHNOLOGYx Environmental Engineering0 (SwePub)2072 hsv//eng
650	7	a NATURVETENSKAPx Geovetenskap och miljövetenskap0 (SwePub)1052 hsv//swe
650	7	a NATURAL SCIENCESx Earth and Related Environmental Sciences0 (SwePub)1052 hsv//eng
700	1	a Vestergren, Robinu Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi4 aut0 (Swepub:su)rove0027
700	1	a Xu, Lin4 aut
700	1	a Zhou, Zhen4 aut
700	1	a Li, Chuangxiu4 aut
700	1	a Liang, Yong4 aut
700	1	a Cai, Yaqi4 aut
710	2	a Stockholms universitetb Institutionen för miljövetenskap och analytisk kemi4 org
773	0	t Environmental Science and Technologyd : American Chemical Society (ACS)g 50:5, s. 2396-2404q 50:5<2396-2404x 0013-936Xx 1520-5851
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-128510
856	4 8	u https://doi.org/10.1021/acs.est.5b05849

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