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Sökning: WFRF:(Leynaert Bénédicte) > Early-life risk fac...

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FältnamnIndikatorerMetadata
00003565naa a2200469 4500
001oai:DiVA.org:uu-162382
003SwePub
008111130s2011 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1623822 URI
0247 a https://doi.org/10.1016/j.jaci.2011.05.0392 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Matheson, Melanie Claire4 aut
2451 0a Early-life risk factors and incidence of rhinitis :b Results from the European Community Respiratory Health Study - an international population-based cohort study
264 1b Elsevier BV,c 2011
338 a print2 rdacarrier
520 a Background: Rhinitis is an increasingly common condition with a heavy health care burden, but relatively little is known about its risk factors. Objective: To examine the association between early-life factors and the development of rhinitis in the European Community Respiratory Health Study (ECRHS). Methods: In 1992-1994, community-based samples of 20-44-year-old people were recruited from 48 centers in 22 countries. On average, 8.9 years later, 28 centers reinvestigated their samples. Onset of rhinitis was reported by 8486 participants in interviewer-led questionnaires. Cox regression was used to assess independent predictors of rhinitis at ages <= 5, 6-10, 11-20, and >= 21 years. Results: The crude lifelong incidence of rhinitis was 7.00/1000/year (men) and 7.95/1000/year (women) (P = .002). Women developed less rhinitis in later childhood (hazard ratios [HR], 0.63; 95% CI, 0.47-0.85) and more rhinitis in adulthood (HR, 1.36; 95% CI, 1.11-1.66) than did men. In atopic subjects, siblings were associated with lower risk of rhinitis throughout life (pooled HR, 0.94; 95% CI, 0.91-0.98 per 1 sibling). Early contact with children in the family or day care was associated with less incidence of rhinitis, predominantly before age 5 years (HR, 0.84; 95% CI, 0.72-0.99). Early childhood pets or growing up on a farm was associated with less incidence of rhinitis in adolescence (HR, 0.50; 95% CI, 0.37-0.68). Combining these factors showed evidence of a dose-response relationship (trend P = .0001). Conclusions: Gender is a strong risk factor for rhinitis, with age patterns varying according to atopic status. Protective effects of early contact with children and animals were suggested for incident rhinitis, with risk patterns varying by age window and atopic status.
653 a Rhinitis
653 a atopy
653 a gender
653 a pet exposure
653 a siblings
653 a farming lifestyle
7001 a Dharmage, Shyamali Chandrika4 aut
7001 a Abramson, Michael John4 aut
7001 a Walters, Eugene Haydn4 aut
7001 a Sunyer, Jordi4 aut
7001 a de Marco, Roberto4 aut
7001 a Leynaert, Benedicte4 aut
7001 a Heinrich, Joachim4 aut
7001 a Jarvis, Deborah4 aut
7001 a Norbäck, Danu Uppsala universitet,Arbets- och miljömedicin4 aut0 (Swepub:uu)dagnorba
7001 a Raherison, Chantal4 aut
7001 a Wjst, Matthias4 aut
7001 a Svanes, Cecilie4 aut
7102 a Uppsala universitetb Arbets- och miljömedicin4 org
7730 t Journal of Allergy and Clinical Immunologyd : Elsevier BVg 128:4, s. 816-823.e5q 128:4<816-823.e5x 0091-6749x 1097-6825
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-162382
8564 8u https://doi.org/10.1016/j.jaci.2011.05.039

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