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Host genetic resistance to symptomatic norovirus (GGII.4) infections in Denmark

Kindberg, Elin, 1981- (author)
Linköpings universitet,Molekylär virologi,Hälsouniversitetet
Åkerlind, Britt, 1960- (author)
Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Klinisk mikrobiologi
Johnsen, Christina (author)
Department of Virology, Statens Serum Institut, Copenhagen, Denmark4;
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Knudsen, Jenny Dahl (author)
Department of Microbiology, Hvidovre Hospital, Hvidovre, Denmark
Heltberg, Ole (author)
Department of Microbiology, Næstved Hospital, Næstved, Denmark
Larson, Göran, 1953 (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Göteborg, Sweden
Böttiger, Blenda (author)
Department of Virology, Statens Serum Institut, Copenhagen, Denmark
Svensson, Lennart, 1954- (author)
Linköpings universitet,Molekylär virologi,Hälsouniversitetet
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 (creator_code:org_t)
2007
2007
English.
In: Journal of Clinical Microbiology. - 0095-1137 .- 1098-660X. ; 45:8, s. 2720-2
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • A total of 61 individuals involved in five norovirus outbreaks in Denmark were genotyped at nucleotides 428 and 571 of the FUT2 gene, determining secretor status, i.e., the presence of ABH antigens in secretions and on mucosa. A strong correlation (P = 0.003) was found between the secretor phenotype and symptomatic disease, extending previous knowledge and confirming that nonsense mutations in the FUT2 gene provide protection against symptomatic norovirus (GGII.4) infections. Copyright © 2007, American Society for Microbiology. All Rights Reserved.

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