WFRF:(Olsson Rolf)
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Screening for biomarkers in plasma from patients with gangrenous phlegmonous appendicitis using CE and CEC in combination with MS
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- Johannesson, Nina (author)
- Uppsala universitet,Institutionen för fysikalisk och analytisk kemi
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- Olsson, Louise (author)
- Karolinska Institutet
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- Bäckström, Daniel (author)
- Uppsala universitet,Institutionen för fysikalisk och analytisk kemi
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- (creator_code:org_t)
- Wiley, 2007
- 2007
- English.
- In: Electrophoresis. - : Wiley. - 0173-0835 .- 1522-2683. ; 28:9, s. 1435-1443
- Journal article (peer-reviewed)
Abstract
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- Today a high degree of "false" appendicitis diagnoses are occurring. In this study, a screening experiment of biomarkers of two different kinds of appendicitis, gangrenous and phlegmonous, were conducted with CE and CEC coupled to MS. Plasma samples were obtained from patients pre- and post-surgery. A large amount of data was generated to be able to compare them, and chemometrics tools were utilized to visualize the differences. Indicative patterns were found for both pre- and post-surgery of the two types of inflammation as well as between them. The divergences were traced back to the MS peaks obtained in the CE- and CEC-MS setups as possible biomarkers for the two forms of appendicitis.
Keyword
- Appendicitis
- Biomarker
- Fourier transform ion cyclotron resonance-MS
- Open tubular CEC
- TOF-MS
- MEDICINE
- MEDICIN
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- ref (subject category)
- art (subject category)
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