Search: ((WFRF:(Kaaks Rudolf)) srt2:(2015-2019) pers:(Weiderpass Elisabete) pers:(Quirós J. Ramón)) srt2:(2015) >
The Association bet...
The Association between Glyceraldehyde-Derived Advanced Glycation End-Products and Colorectal Cancer Risk
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Kong, So Yeon (author)
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Takeuchi, Masayoshi (author)
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Hyogo, Hideyuki (author)
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McKeown-Eyssen, Gail (author)
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Yamagishi, Sho-Ichi (author)
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Chayama, Kazuaki (author)
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O'Brien, Peter J. (author)
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Ferrari, Pietro (author)
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Overvad, Kim (author)
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Olsen, Anja (author)
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Tjonneland, Anne (author)
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Boutron-Ruault, Marie-Christine (author)
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Bastide, Nadia (author)
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Carbonnel, Franck (author)
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Kuehn, Tilman (author)
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Kaaks, Rudolf (author)
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Boeing, Heiner (author)
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Aleksandrova, Krasimira (author)
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Trichopoulou, Antonia (author)
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Lagiou, Pagona (author)
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Vasilopoulou, Effie (author)
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Masala, Giovanna (author)
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Pala, Valeria (author)
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De Magistris, Maria Santucci (author)
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Tumino, Rosario (author)
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Naccarati, Alessio (author)
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Bueno-De-Mesquita, H. B. (author)
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Peeters, Petra H. (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Quiros, J. Ramon (author)
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Jakszyn, Paula (author)
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Sanchez, Maria-Jose (author)
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Dorronsoro, Miren (author)
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Gavrila, Diana (author)
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Ardanaz, Eva (author)
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- Rutegård, Martin (author)
- Umeå universitet,Kirurgi
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- Nyström, Hanna (author)
- Umeå universitet,Kirurgi
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Wareham, Nicholas J. (author)
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Khaw, Kay-Tee (author)
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Bradbury, Kathryn E. (author)
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Romieu, Isabelle (author)
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Freisling, Heinz (author)
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Stavropoulou, Faidra (author)
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Gunter, Marc J. (author)
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Cross, Amanda J. (author)
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Riboli, Elio (author)
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Jenab, Mazda (author)
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Bruce, W. Robert (author)
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(creator_code:org_t)
- 2015
- 2015
- English.
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In: Cancer Epidemiology, Biomarkers and Prevention. - 1055-9965 .- 1538-7755. ; 24:12, s. 1855-1863
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: A large proportion of colorectal cancers are thought to be associated with unhealthy dietary and lifestyle exposures, particularly energy excess, obesity, hyperinsulinemia, and hyperglycemia. It has been suggested that these processes stimulate the production of toxic reactive carbonyls from sugars such as glyceraldehyde. Glyceraldehyde contributes to the production of a group of compounds known as glyceraldehyde-derived advanced glycation end-products (glycer-AGEs), which may promote colorectal cancer through their proinflammatory and pro-oxidative properties. The objective of this study nested within a prospective cohort was to explore the association of circulating glycer-AGEs with risk of colorectal cancer. Methods: A total of 1,055 colorectal cancer cases (colon n = 659; rectal n = 396) were matchced (1: 1) to control subjects. Circulating glycer-AGEs were measured by a competitive ELISA. Multivariable conditional logistic regression models were used to calculate ORs and 95% confidence intervals (95% CI), adjusting for potential confounding factors, including smoking, alcohol, physical activity, body mass index, and diabetes status. Results: Elevated glycer-AGEs levels were not associated with colorectal cancer risk (highest vs. lowest quartile, 1.10; 95% CI, 0.82-1.49). Subgroup analyses showed possible divergence by anatomical subsites (OR for colon cancer, 0.83; 95% CI, 0.571.22; OR for rectal cancer, 1.90; 95% CI, 1.14-3.19; Pheterogeneity = 0.14). Conclusions: In this prospective study, circulating glycer-AGEs were not associated with risk of colon cancer, but showed a positive association with the risk of rectal cancer. Impact: Further research is needed to clarify the role of toxic products of carbohydrate metabolism and energy excess in colorectal cancer development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
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- art (subject category)
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- By the author/editor
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Kong, So Yeon
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Takeuchi, Masayo ...
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Hyogo, Hideyuki
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McKeown-Eyssen, ...
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Yamagishi, Sho-I ...
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Chayama, Kazuaki
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show more...
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O'Brien, Peter J ...
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Ferrari, Pietro
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Overvad, Kim
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Olsen, Anja
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Tjonneland, Anne
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Boutron-Ruault, ...
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Bastide, Nadia
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Carbonnel, Franc ...
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Kuehn, Tilman
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Kaaks, Rudolf
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Boeing, Heiner
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Aleksandrova, Kr ...
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Trichopoulou, An ...
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Lagiou, Pagona
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Vasilopoulou, Ef ...
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Masala, Giovanna
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Pala, Valeria
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De Magistris, Ma ...
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Tumino, Rosario
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Naccarati, Aless ...
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Bueno-De-Mesquit ...
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Peeters, Petra H ...
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Weiderpass, Elis ...
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Quiros, J. Ramon
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Jakszyn, Paula
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Sanchez, Maria-J ...
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Dorronsoro, Mire ...
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Gavrila, Diana
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Ardanaz, Eva
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Rutegård, Martin
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Nyström, Hanna
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Wareham, Nichola ...
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Khaw, Kay-Tee
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Bradbury, Kathry ...
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Romieu, Isabelle
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Freisling, Heinz
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Stavropoulou, Fa ...
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Gunter, Marc J.
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Cross, Amanda J.
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Riboli, Elio
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Jenab, Mazda
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Bruce, W. Robert
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
- Articles in the publication
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Cancer Epidemiol ...
- By the university
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Umeå University
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Karolinska Institutet