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Genome-wide meta-an...
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels
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Kilpeläinen, Tuomas O (author)
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Carli, Jayne F Martin (author)
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Skowronski, Alicja A (author)
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show more...
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Sun, Qi (author)
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Kriebel, Jennifer (author)
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Feitosa, Mary F (author)
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- Hedman, Åsa K (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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Drong, Alexander W (author)
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Hayes, James E (author)
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Zhao, Jinghua (author)
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Pers, Tune H (author)
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Schick, Ursula (author)
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Grarup, Niels (author)
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Kutalik, Zoltán (author)
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Trompet, Stella (author)
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Mangino, Massimo (author)
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Kristiansson, Kati (author)
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Beekman, Marian (author)
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Lyytikäinen, Leo-Pekka (author)
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- Eriksson, Joel (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research
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Henneman, Peter (author)
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Lahti, Jari (author)
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Tanaka, Toshiko (author)
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Luan, Jian'an (author)
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Greco M, Fabiola Del (author)
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Pasko, Dorota (author)
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- Renström, Frida (author)
- Umeå University,Lund University,Lunds universitet,Umeå universitet,Enheten för biobanksforskning,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö 20502, Sweden,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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Willems, Sara M (author)
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Mahajan, Anubha (author)
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Rose, Lynda M (author)
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Guo, Xiuqing (author)
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Liu, Yongmei (author)
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Kleber, Marcus E (author)
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Pérusse, Louis (author)
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Gaunt, Tom (author)
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- Söderberg, Stefan (author)
- Umeå universitet,Kardiologi
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Ju Sung, Yun (author)
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Ramos, Yolande F (author)
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Amin, Najaf (author)
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Amuzu, Antoinette (author)
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Barroso, Inês (author)
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Bellis, Claire (author)
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Blangero, John (author)
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Buckley, Brendan M (author)
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Böhringer, Stefan (author)
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I Chen, Yii-Der (author)
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de Craen, Anton J N (author)
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Crosslin, David R (author)
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Dale, Caroline E (author)
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Dastani, Zari (author)
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Day, Felix R (author)
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Deelen, Joris (author)
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Delgado, Graciela E (author)
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Demirkan, Ayse (author)
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Finucane, Francis M (author)
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Ford, Ian (author)
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Garcia, Melissa E (author)
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Gieger, Christian (author)
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- Gustafsson, Stefan (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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- Hallmans, Göran (author)
- Umeå universitet,Näringsforskning,Enheten för biobanksforskning
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Hankinson, Susan E (author)
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Havulinna, Aki S (author)
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Herder, Christian (author)
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Hernandez, Dena (author)
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Hicks, Andrew A (author)
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Hunter, David J (author)
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Illig, Thomas (author)
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- Ingelsson, Erik (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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Ioan-Facsinay, Andreea (author)
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- Jansson, John-Olov, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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Jenny, Nancy S (author)
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Jørgensen, Marit E (author)
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Jørgensen, Torben (author)
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- Karlsson, Magnus (author)
- Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,Skåne University Hospital
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Koenig, Wolfgang (author)
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Kraft, Peter (author)
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Kwekkeboom, Joanneke (author)
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Laatikainen, Tiina (author)
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Ladwig, Karl-Heinz (author)
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LeDuc, Charles A (author)
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Lowe, Gordon (author)
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Lu, Yingchang (author)
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Marques-Vidal, Pedro (author)
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Meisinger, Christa (author)
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Menni, Cristina (author)
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Morris, Andrew P (author)
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Myers, Richard H (author)
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Männistö, Satu (author)
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Nalls, Mike A (author)
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Paternoster, Lavinia (author)
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Peters, Annette (author)
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Pradhan, Aruna D (author)
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Rankinen, Tuomo (author)
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Rasmussen-Torvik, Laura J (author)
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Rathmann, Wolfgang (author)
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Rice, Treva K (author)
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Brent Richards, J (author)
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Ridker, Paul M (author)
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Sattar, Naveed (author)
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Savage, David B (author)
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Söderberg, Stefan (author)
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Timpson, Nicholas J (author)
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- Vandenput, Liesbeth, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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van Heemst, Diana (author)
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Uh, Hae-Won (author)
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Vohl, Marie-Claude (author)
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Walker, Mark (author)
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Wichmann, Heinz-Erich (author)
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Widén, Elisabeth (author)
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Wood, Andrew R (author)
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Yao, Jie (author)
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Zeller, Tanja (author)
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Zhang, Yiying (author)
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Meulenbelt, Ingrid (author)
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Kloppenburg, Margreet (author)
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Astrup, Arne (author)
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Sørensen, Thorkild I A (author)
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Sarzynski, Mark A (author)
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Rao, D C (author)
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Jousilahti, Pekka (author)
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Vartiainen, Erkki (author)
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Hofman, Albert (author)
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Rivadeneira, Fernando (author)
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Uitterlinden, André G (author)
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Kajantie, Eero (author)
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Osmond, Clive (author)
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Palotie, Aarno (author)
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Eriksson, Johan G (author)
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Heliövaara, Markku (author)
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Knekt, Paul B (author)
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Koskinen, Seppo (author)
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Jula, Antti (author)
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Perola, Markus (author)
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Huupponen, Risto K (author)
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Viikari, Jorma S (author)
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Kähönen, Mika (author)
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Lehtimäki, Terho (author)
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Raitakari, Olli T (author)
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- Mellström, Dan, 1945 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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- Lorentzon, Mattias, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Casas, Juan P (author)
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Bandinelli, Stefanie (author)
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März, Winfried (author)
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Isaacs, Aaron (author)
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van Dijk, Ko W (author)
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van Duijn, Cornelia M (author)
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Harris, Tamara B (author)
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Bouchard, Claude (author)
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Allison, Matthew A (author)
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Chasman, Daniel I (author)
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi
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Scott, Robert A (author)
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Langenberg, Claudia (author)
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Wareham, Nicholas J (author)
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Ferrucci, Luigi (author)
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Frayling, Timothy M (author)
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Pramstaller, Peter P (author)
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Borecki, Ingrid B (author)
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Waterworth, Dawn M (author)
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Bergmann, Sven (author)
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Waeber, Gérard (author)
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Vollenweider, Peter (author)
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Vestergaard, Henrik (author)
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Hansen, Torben (author)
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Pedersen, Oluf (author)
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Hu, Frank B (author)
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Eline Slagboom, P (author)
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Grallert, Harald (author)
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Spector, Tim D (author)
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Jukema, J W (author)
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Klein, Robert J (author)
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Schadt, Erik E (author)
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- Franks, Paul W. (author)
- Umeå University,Lund University,Lunds universitet,Umeå universitet,Medicin,Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachussetts 02115, USA; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö 20502, Sweden,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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Lindgren, Cecilia M (author)
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Leibel, Rudolph L (author)
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Loos, Ruth J F (author)
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(creator_code:org_t)
- 2016-02-01
- 2016
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe obesity, no common loci regulating circulating leptin levels have been uncovered. Therefore, we performed a genome-wide association study (GWAS) of circulating leptin levels from 32,161 individuals and followed up loci reaching P<10(-6) in 19,979 additional individuals. We identify five loci robustly associated (P<5 × 10(-8)) with leptin levels in/near LEP, SLC32A1, GCKR, CCNL1 and FTO. Although the association of the FTO obesity locus with leptin levels is abolished by adjustment for BMI, associations of the four other loci are independent of adiposity. The GCKR locus was found associated with multiple metabolic traits in previous GWAS and the CCNL1 locus with birth weight. Knockdown experiments in mouse adipose tissue explants show convincing evidence for adipogenin, a regulator of adipocyte differentiation, as the novel causal gene in the SLC32A1 locus influencing leptin levels. Our findings provide novel insights into the regulation of leptin production by adipose tissue and open new avenues for examining the influence of variation in leptin levels on adiposity and metabolic health.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Keyword
- adipose tissue; animal tissue; Article; birth weight; body mass; controlled study; explant; female; follow up; gene locus; genetic association; genetic trait; human; major clinical study; male; meta analysis (topic); mouse; nonhuman; obesity
Publication and Content Type
- ref (subject category)
- art (subject category)
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Kilpeläinen, Tuo ...
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Carli, Jayne F M ...
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Skowronski, Alic ...
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Sun, Qi
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Kriebel, Jennife ...
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Feitosa, Mary F
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show more...
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Hedman, Åsa K
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Drong, Alexander ...
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Hayes, James E
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Zhao, Jinghua
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Pers, Tune H
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Schick, Ursula
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Grarup, Niels
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Kutalik, Zoltán
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Trompet, Stella
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Mangino, Massimo
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Kristiansson, Ka ...
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Beekman, Marian
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Lyytikäinen, Leo ...
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Eriksson, Joel
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Henneman, Peter
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Lahti, Jari
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Tanaka, Toshiko
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Luan, Jian'an
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Greco M, Fabiola ...
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Pasko, Dorota
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Renström, Frida
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Willems, Sara M
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Mahajan, Anubha
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Rose, Lynda M
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Guo, Xiuqing
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Liu, Yongmei
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Kleber, Marcus E
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Pérusse, Louis
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Gaunt, Tom
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Söderberg, Stefa ...
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Ju Sung, Yun
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Ramos, Yolande F
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Amin, Najaf
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Amuzu, Antoinett ...
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Barroso, Inês
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Bellis, Claire
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Blangero, John
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Buckley, Brendan ...
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Böhringer, Stefa ...
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I Chen, Yii-Der
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de Craen, Anton ...
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Crosslin, David ...
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Dale, Caroline E
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Dastani, Zari
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Day, Felix R
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Deelen, Joris
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Delgado, Graciel ...
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Demirkan, Ayse
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Finucane, Franci ...
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Ford, Ian
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Garcia, Melissa ...
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Gieger, Christia ...
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Gustafsson, Stef ...
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Hallmans, Göran
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Hankinson, Susan ...
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Havulinna, Aki S
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Herder, Christia ...
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Hernandez, Dena
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Hicks, Andrew A
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Hunter, David J
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Illig, Thomas
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Ingelsson, Erik
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Ioan-Facsinay, A ...
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Jansson, John-Ol ...
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Jenny, Nancy S
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Jørgensen, Marit ...
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Jørgensen, Torbe ...
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Karlsson, Magnus
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Koenig, Wolfgang
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Kraft, Peter
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Kwekkeboom, Joan ...
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Laatikainen, Tii ...
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Ladwig, Karl-Hei ...
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LeDuc, Charles A
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Lowe, Gordon
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Lu, Yingchang
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Marques-Vidal, P ...
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Meisinger, Chris ...
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Menni, Cristina
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Morris, Andrew P
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Myers, Richard H
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Männistö, Satu
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Nalls, Mike A
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Paternoster, Lav ...
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Peters, Annette
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Pradhan, Aruna D
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Rankinen, Tuomo
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Rasmussen-Torvik ...
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Rathmann, Wolfga ...
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Rice, Treva K
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Brent Richards, ...
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Ridker, Paul M
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Sattar, Naveed
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Savage, David B
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Timpson, Nichola ...
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Vandenput, Liesb ...
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van Heemst, Dian ...
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Uh, Hae-Won
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Vohl, Marie-Clau ...
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Walker, Mark
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Wichmann, Heinz- ...
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Widén, Elisabeth
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Wood, Andrew R
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Yao, Jie
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Zeller, Tanja
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Zhang, Yiying
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Meulenbelt, Ingr ...
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Kloppenburg, Mar ...
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Astrup, Arne
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Sørensen, Thorki ...
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Sarzynski, Mark ...
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Rao, D C
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Jousilahti, Pekk ...
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Vartiainen, Erkk ...
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Hofman, Albert
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Rivadeneira, Fer ...
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Uitterlinden, An ...
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Kajantie, Eero
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Osmond, Clive
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Palotie, Aarno
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Eriksson, Johan ...
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Heliövaara, Mark ...
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Knekt, Paul B
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Koskinen, Seppo
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Jula, Antti
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Perola, Markus
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Huupponen, Risto ...
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Viikari, Jorma S
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Kähönen, Mika
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Lehtimäki, Terho
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Raitakari, Olli ...
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Mellström, Dan, ...
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Lorentzon, Matti ...
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Casas, Juan P
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Bandinelli, Stef ...
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März, Winfried
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Isaacs, Aaron
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van Dijk, Ko W
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van Duijn, Corne ...
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Harris, Tamara B
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Bouchard, Claude
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Allison, Matthew ...
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Chasman, Daniel ...
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Ohlsson, Claes, ...
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Lind, Lars
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Scott, Robert A
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Langenberg, Clau ...
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Wareham, Nichola ...
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Ferrucci, Luigi
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Frayling, Timoth ...
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Pramstaller, Pet ...
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Borecki, Ingrid ...
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Waterworth, Dawn ...
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Bergmann, Sven
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Waeber, Gérard
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Vollenweider, Pe ...
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Vestergaard, Hen ...
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Hansen, Torben
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Pedersen, Oluf
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Hu, Frank B
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Eline Slagboom, ...
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Grallert, Harald
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Spector, Tim D
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Jukema, J W
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Klein, Robert J
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Schadt, Erik E
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Franks, Paul W.
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Lindgren, Cecili ...
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Leibel, Rudolph ...
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Loos, Ruth J F
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
- Articles in the publication
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Nature Communica ...
- By the university
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Uppsala University
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Umeå University
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Lund University
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University of Gothenburg