AML and Ets proteins regulate the I alpha1 germ-line promoter.

Xie, Xiao-Qi (author): Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)

Pardali, Evangelia (author): Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)

Holm, Magnus (author): Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)

Sideras, Paschalis (author): Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)

Grundström, Thomas (author): Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)

(creator_code:org_t)

1999
1999
English.
In: European Journal of Immunology. - 0014-2980 .- 1521-4141. ; 29:2, s. 488-498

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; show less...

Abstract Subject headings

The immunoglobulin heavy chain (IgH) class switch recombination of B lymphocytes preferentially targets unrearranged IgH genes that have already been rendered transcriptionally active. Transcription of the germ-line IgH genes is controlled by intervening (I) regions upstream of their switch regions. The I alpha1 promoter activates transcription of the human germ-line C alpha1 gene for IgA1 and mediates the transforming growth factor (TGF)-beta1 responsiveness of this locus. Here we show that the I alpha1 promoter contains several binding sites for the AML/PEBP2/CBF family of transcription factors and that AML and Ets proteins are major regulators of the basal and TGF-beta-inducible promoter activity. Our data constitute a starting point for studies to elucidate the molecular mechanism by which TGF-beta regulates IgA production.

By the author/editor: Xie, Xiao-Qi; Pardali, Evangel ...; Holm, Magnus; Sideras, Paschal ...; Grundström, Thom ...

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