Search: (L773:1742 5689 OR L773:1742 5662)
> (2020-2023) >
Modelling preventiv...
Modelling preventive measures and their effect on generation times in emerging epidemics
-
- Favero, Martina (author)
- Stockholms universitet,Matematiska institutionen
-
Scalia Tomba, Gianpaolo (author)
-
- Britton, Tom, 1965- (author)
- Stockholms universitet,Matematiska institutionen
-
(creator_code:org_t)
- 2022-06-15
- 2022
- English.
-
In: Journal of the Royal Society Interface. - : The Royal Society. - 1742-5689 .- 1742-5662. ; 19:191
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- We present a stochastic epidemic model to study the effect of various preventive measures, such as uniform reduction of contacts and transmission, vaccination, isolation, screening and contact tracing, on a disease outbreak in a homogeneously mixing community. The model is based on an infectivity process, which we define through stochastic contact and infectiousness processes, so that each individual has an independent infectivity profile. In particular, we monitor variations of the reproduction number and of the distribution of generation times. We show that some interventions, i.e. uniform reduction and vaccination, affect the former while leaving the latter unchanged, whereas other interventions, i.e. isolation, screening and contact tracing, affect both quantities. We provide a theoretical analysis of the variation of these quantities, and we show that, in practice, the variation of the generation time distribution can be significant and that it can cause biases in the estimation of reproduction numbers. The framework, because of its general nature, captures the properties of many infectious diseases, but particular emphasis is on COVID-19, for which numerical results are provided.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology (hsv//eng)
Keyword
- epidemic modelling
- preventive measures
- estimation bias
- generation time
- reproduction number
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database