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Minimal selective c...
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Lundström, Sara,1981Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
(author)
Minimal selective concentrations of tetracycline in complex aquatic bacterial biofilms
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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Elsevier BV,2016
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:research.chalmers.se:bbd52892-f054-4235-aeb3-3f6d03e7e82d
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https://research.chalmers.se/publication/234981URI
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https://doi.org/10.1016/j.scitotenv.2016.02.103DOI
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https://gup.ub.gu.se/publication/234981URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-118609URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Selection pressure generated by antibiotics released into the environment could enrich for antibiotic resistance genes and antibiotic resistant bacteria, thereby increasing the risk for transmission to humans and animals. Tetracyclines comprise an antibiotic class of great importance to both human and animal health. Accordingly, residues of tetracycline are commonly detected in aquatic environments. To assess if tetracycline pollution in aquatic environments promotes development of resistance, we determined minimal selective concentrations (MSCs) in biofilms of complex aquatic bacterial communities using both phenotypic and genotypic assays. Tetracycline significantly increased the relative abundance of resistant bacteria at 10 μg/L, while specific tet genes (tetA and tetG) increased significantly at the lowest concentration tested (1 μg/L). Taxonomic composition of the biofilm communities was altered with increasing tetracycline concentrations. Metagenomic analysis revealed a concurrent increase of several tet genes and a range of other genes providing resistance to different classes of antibiotics (e.g. cmlA, floR, sul1, and mphA), indicating potential for co-selection. Consequently, MSCs for the tet genes of ≤ 1 μg/L suggests that current exposure levels in e.g. sewage treatment plants could be sufficient to promote resistance. The methodology used here to assess MSCs could be applied in risk assessment of other antibiotics as well.
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Östman, MarcusUmeå universitet,Kemiska institutionen(Swepub:umu)maas0016
(author)
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Bengtsson-Palme, Johan,1985Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xbengg
(author)
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Rutgersson, Carolin,1983Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xrutca
(author)
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Thoudal, MalinGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
(author)
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Sircar, TrirantaGothenburg University,Göteborgs universitet,Institutionen för biologi och miljövetenskap,Department of Biological and Environmental Sciences
(author)
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Blanck, Hans,1950Gothenburg University,Göteborgs universitet,Institutionen för biologi och miljövetenskap,Department of Biological and Environmental Sciences(Swepub:gu)xblaha
(author)
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Eriksson, Martin,1970Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)marte
(author)
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Tysklind, MatsUmeå universitet,Kemiska institutionen(Swepub:umu)maty0001
(author)
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Flach, Carl-Fredrik,1977Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xflaca
(author)
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Larsson, D. G. Joakim,1969Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xlarjo
(author)
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Göteborgs universitetInstitutionen för biomedicin, avdelningen för infektionssjukdomar
(creator_code:org_t)
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In:Science of the Total Environment: Elsevier BV553, s. 587-950048-96971879-1026
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