Search: (WFRF:(Aaby Peter)) hsvcat:3
> (2005-2009) >
Effect of 50 000 IU...
Effect of 50 000 IU vitamin A given with BCG vaccine on mortality in infants in Guinea-Bissau: randomised placebo controlled trial
-
Benn, Christine Stabell (author)
-
Diness, Birgitte Rode (author)
-
- Roth, Adam (author)
- Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups
-
show more...
-
Nante, Ernesto (author)
-
Fisker, Ane Baerent (author)
-
Lisse, Ida Maria (author)
-
Yazdanbakhsh, Maria (author)
-
Whittle, Hilton (author)
-
Rodrigues, Amabelia (author)
-
Aaby, Peter (author)
-
show less...
-
(creator_code:org_t)
- 2008
- 2008
- English.
-
In: BMJ (International Edition). - 0959-8146. ; 336:7658, s. 1416-1416
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Objective To investigate the effect of high dose vitamin A supplementation given with BCG vaccine at birth in an African setting with high infant mortality. Design Randomised placebo controlled trial. Setting Bandim Health Project's demographic surveillance system in Guinea-Bissau, covering approximately 90 000 inhabitants. Participants 4345 infants due to receive BCG. Intervention Infants were randomised to 50 000 IU vitamin A or placebo and followed until age 12 months. Main outcome measure Mortality rate ratios. Results 174 children died during follow-up (mortality=47/ 1000 person-years). Vitamin A supplementation was not significantly associated with mortality; the mortality rate ratio was 1.07 (95% confidence interval 0.79 to 1.44). The effect was 1.00 (0.65 to 1.56) during the first four months and 1.13 (0.75 to 1.68) from 4 to 12 months of age. The mortality rate ratio in boys was 0.84 (0.55 to 1.27) compared with 1.39 (0.90 to 2.14) in girls (P for interaction=0.10). An explorative analysis revealed a strong interaction between vitamin A and season of administration. Conclusions Vitamin A supplementation given with BCG vaccine at birth had no significant benefit in this African setting. Although little doubt exists that vitamin A supplementation reduces mortality in older children, a global recommendation of supplementation for all newborn infants may not contribute to better survival. Registration Clinical trials NCT00168597.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Benn, Christine ...
-
Diness, Birgitte ...
-
Roth, Adam
-
Nante, Ernesto
-
Fisker, Ane Baer ...
-
Lisse, Ida Maria
-
show more...
-
Yazdanbakhsh, Ma ...
-
Whittle, Hilton
-
Rodrigues, Amabe ...
-
Aaby, Peter
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Microbiology in ...
- Articles in the publication
-
BMJ (Internation ...
- By the university
-
Lund University