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Effect of 50 000 IU...
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Benn, Christine Stabell
(author)
Effect of 50 000 IU vitamin A given with BCG vaccine on mortality in infants in Guinea-Bissau: randomised placebo controlled trial
- Article/chapterEnglish2008
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LIBRIS-ID:oai:lup.lub.lu.se:18733ef2-e142-41ad-859b-93653b6c6bdc
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https://lup.lub.lu.se/record/1191161URI
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https://doi.org/10.1136/bmj.39542.509444.AEDOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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Objective To investigate the effect of high dose vitamin A supplementation given with BCG vaccine at birth in an African setting with high infant mortality. Design Randomised placebo controlled trial. Setting Bandim Health Project's demographic surveillance system in Guinea-Bissau, covering approximately 90 000 inhabitants. Participants 4345 infants due to receive BCG. Intervention Infants were randomised to 50 000 IU vitamin A or placebo and followed until age 12 months. Main outcome measure Mortality rate ratios. Results 174 children died during follow-up (mortality=47/ 1000 person-years). Vitamin A supplementation was not significantly associated with mortality; the mortality rate ratio was 1.07 (95% confidence interval 0.79 to 1.44). The effect was 1.00 (0.65 to 1.56) during the first four months and 1.13 (0.75 to 1.68) from 4 to 12 months of age. The mortality rate ratio in boys was 0.84 (0.55 to 1.27) compared with 1.39 (0.90 to 2.14) in girls (P for interaction=0.10). An explorative analysis revealed a strong interaction between vitamin A and season of administration. Conclusions Vitamin A supplementation given with BCG vaccine at birth had no significant benefit in this African setting. Although little doubt exists that vitamin A supplementation reduces mortality in older children, a global recommendation of supplementation for all newborn infants may not contribute to better survival. Registration Clinical trials NCT00168597.
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Diness, Birgitte Rode
(author)
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Roth, AdamLund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups(Swepub:lu)med-amr
(author)
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Nante, Ernesto
(author)
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Fisker, Ane Baerent
(author)
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Lisse, Ida Maria
(author)
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Yazdanbakhsh, Maria
(author)
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Whittle, Hilton
(author)
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Rodrigues, Amabelia
(author)
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Aaby, Peter
(author)
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Klinisk mikrobiologi, MalmöForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:BMJ (International Edition)336:7658, s. 1416-14160959-8146
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Diness, Birgitte ...
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Roth, Adam
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Nante, Ernesto
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Fisker, Ane Baer ...
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Lisse, Ida Maria
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Whittle, Hilton
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