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(WFRF:(Ahlbom Anders)) srt2:(2005-2009) pers:(Swerdlow Anthony)
 

Search: (WFRF:(Ahlbom Anders)) srt2:(2005-2009) pers:(Swerdlow Anthony) > Functional polymorp...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003657naa a2200553 4500
001oai:DiVA.org:umu-9690
003SwePub
008080520s2008 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:117048600
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-96902 URI
0247 a https://doi.org/10.1158/1055-9965.EPI-07-27332 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1170486002 URI
040 a (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Bethke, Lara4 aut
2451 0a Functional polymorphisms in folate metabolism genes influence the risk of meningioma and glioma
264 1b American Association for Cancer Research (AACR),c 2008
338 a print2 rdacarrier
520 a Folate metabolism plays an important role in carcinogenesis. To test the hypothesis that polymorphic variation in the folate metabolism genes 5,10-methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTRR), and methionine synthase reductase (MTR) influences the risk of primary brain tumors, we genotyped 1,005 glioma cases, 631 meningioma cases, and 1,101 controls for the MTHFR C677A and A1298C, MTRR A66G, and MTR A2756G variants. MTHFR C677T-A1298C diplotypes were associated with risk of meningioma (P = 0.002) and glioma (P = 0.02); risks were increased with genotypes associated with reduced MTHFR activity. The highest risk of meningioma was associated with heterozygosity for both MTHFR variants [odds ratio (OR), 2.11; 95% confidence interval (95% CI), 1.42-3.12]. The corresponding OR for glioma was 1.23 (95% CI, 0.91-1.66). A significant association between risk of meningioma and homozygosity for MTRR 66G was also observed (OR, 1.41; 95% CI, 1.02-1.94). Our findings provide support for the role of folate metabolism in the development of primary brain tumors. In particular, genotypes associated with increased 5,10-methylenetetrahydrofolate levels are associated with elevated risk.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Webb, Emily4 aut
7001 a Murray, Anne4 aut
7001 a Schoemaker, Minouk4 aut
7001 a Feychting, Mariau Karolinska Institutet4 aut
7001 a Lönn, Stefanu Karolinska Institutet4 aut
7001 a Ahlbom, Andersu Karolinska Institutet4 aut
7001 a Malmer, Beatriceu Umeå universitet,Onkologi4 aut0 (Swepub:umu)bema0010
7001 a Henriksson, Rogeru Umeå universitet,Onkologi4 aut0 (Swepub:umu)rohe0003
7001 a Auvinen, Anssi4 aut
7001 a Kiuru, Anne4 aut
7001 a Salminen, Tiina4 aut
7001 a Johansen, Christoffer4 aut
7001 a Collatz Christensen, Helle4 aut
7001 a Muir, Kenneth4 aut
7001 a McKinney, Patricia4 aut
7001 a Hepworth, Sarah4 aut
7001 a Dimitropoulou, Polyxeni4 aut
7001 a Lophatananon, Artitaya4 aut
7001 a Swerdlow, Anthony4 aut
7001 a Houlston, Richard4 aut
7102 a Karolinska Institutetb Onkologi4 org
7730 t Cancer Epidemiology, Biomarkers and Preventiond : American Association for Cancer Research (AACR)g 17:5, s. 1195-1202q 17:5<1195-1202x 1055-9965x 1538-7755
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-9690
8564 8u https://doi.org/10.1158/1055-9965.EPI-07-2733
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:117048600

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