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Safety evaluation o...
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Honkalampi-Hämäläinen, U.
(author)
Safety evaluation of food contact paper and board using chemical tests and in vitro bioassays : Role of known and unknown substances
- Article/chapterEnglish2010
Publisher, publication year, extent ...
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Informa UK Limited,2010
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:ri-29572
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https://urn.kb.se/resolve?urn=urn:nbn:se:ri:diva-29572URI
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https://doi.org/10.1080/19440040903401358DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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cited By 14
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In vitro toxicological tests have been proposed as an approach to complement the chemical safety assessment of food contact materials, particularly those with a complex or unknown chemical composition such as paper and board. Among the concerns raised regarding the applicability of in vitro tests are the effects of interference of the extractables on the outcome of the cytotoxicity and genotoxicity tests applied and the role of known compounds present in chemically complex materials, such as paper and board, either as constituents or contaminants. To answer these questions, a series of experiments were performed to assess the role of natural substances (wood extracts, resin acids), some additives (diisopropylnaphthalene, phthalates, acrylamide, fluorescent whitening agents) and contaminants (2,4-diaminotoluene, benzo[a]pyrene) in the toxicological profile of paper and board. These substances were individually tested or used to spike actual paper and board extracts. The toxic concentrations of diisopropylnaphthalenes and phthalates were compared with those actually detected in paper and board extracts showing conspicuous toxicity. According to the results of the spiking experiments, the extracts did not affect the toxicity of tested chemicals nor was there any significant metabolic interference in the cases where two compounds were used in tests involving xenobiotic metabolism by the target cells. While the identified substances apparently have a role in the cytotoxicity of some of the project samples, their presence does not explain the total toxicological profile of the extracts. In conclusion, in vitro toxicological testing can have a role in the safety assessment of chemically complex materials in detecting potentially harmful activities not predictable by chemical analysis alone.
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Bradley, E.L.
(author)
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Castle, L.
(author)
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Severin, I.
(author)
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Dahbi, L.
(author)
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Dahlman, OlofRISE,Innventia
(author)
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Lhuguenot, J.-C.
(author)
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Andersson, M.A.
(author)
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Hakulinen, P.
(author)
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Hoornstra, D.
(author)
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Mäki-Paakkanen, J.
(author)
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Salkinoja-Salonen, M.
(author)
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Turco, L.
(author)
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Stammati, A.
(author)
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Zucco, F.
(author)
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Weber, A.
(author)
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von Wright, A.
(author)
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RISEInnventia
(creator_code:org_t)
Related titles
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In:Food Additives and Contaminants: Informa UK Limited27:3, s. 406-1150265-203X1464-5122
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In:Food Additives & Contaminants: Part A: Informa UK Limited27:3, s. 406-1151944-00491944-0057
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Honkalampi-Hämäl ...
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Bradley, E.L.
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Castle, L.
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Severin, I.
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Dahbi, L.
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Dahlman, Olof
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Lhuguenot, J.-C.
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Andersson, M.A.
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Hakulinen, P.
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Hoornstra, D.
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Mäki-Paakkanen, ...
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Salkinoja-Salone ...
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Turco, L.
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Stammati, A.
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Zucco, F.
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Weber, A.
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von Wright, A.
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- About the subject
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Materials Engine ...
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and Paper Pulp and F ...
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Food Additives a ...
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