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Sökning: (WFRF:(Edén Engström Britt)) > (2001-2004) > Low dose dehydroepi...

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FältnamnIndikatorerMetadata
00005104naa a2200841 4500
001oai:gup.ub.gu.se/226569
003SwePub
008240910s2002 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/2265692 URI
0247 a https://doi.org/10.1210/jcem.87.5.84942 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Johannsson, Gudmundur,d 1960u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine4 aut0 (Swepub:gu)xjgudn
2451 0a Low dose dehydroepiandrosterone affects behavior in hypopituitary androgen-deficient women: a placebo-controlled trial.
264 1b The Endocrine Society,c 2002
520 a Thirty-eight women, aged 25-65 yr, with androgen deficiency due to hypopituitarism were treated with oral dehydroepiandrosterone (DHEA; 30 mg/d if <45 yr of age and 20 mg if > or =45 yr of age) for 6 months in a randomized, placebo-controlled, double blind study, followed by a 6-month open treatment period. The administration of DHEA raised the serum levels of DHEAS to normal age-related reference ranges and increased androstenedione and T to subnormal levels. Androgen effects on skin and/or pubic and/or axillary hair were observed in 84% (32 of 38) of the women after all received 6 months of DHEA treatment. No such effects were observed after the placebo treatment. These effects after 6 months were correlated with the serum levels of DHEAS (r = 0.37; P = 0.03), androstenedione (r = 0.42; P = 0.01), and T (r = 0.37; P = 0.03). The percentages of partners who reported improved alertness, stamina, and initiative by their spouses were 70%, 64%, and 55%, respectively, in the DHEA group and 11%, 6%, and 11%, respectively, in the placebo group (P < 0.05). According to the partners, sexual relations tended to improve compared with placebo (P = 0.06). After 6 months of treatment, increased sexual interest or activity was reported by 50% of the women taking 30 mg DHEA, by none taking 20 mg DHEA, and by two women taking placebo (P = NS). Compared with levels after placebo administration, high density lipoprotein cholesterol and apolipoprotein A-1 levels decreased after DHEA. Serum concentrations of IGF-I, serum markers of bone metabolism, and bone density did not change. In conclusion, oral administration of a low dose of DHEA to adult hypopituitary women induced androgen effects on skin and axillary and pubic hair as well as changes in behavior, with only minor effects on metabolism.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a Adult
653 a Androgens
653 a blood
653 a deficiency
653 a Behavior
653 a drug effects
653 a Body Composition
653 a drug effects
653 a Bone and Bones
653 a drug effects
653 a metabolism
653 a Dehydroepiandrosterone
653 a administration & dosage
653 a adverse effects
653 a therapeutic use
653 a Double-Blind Method
653 a Female
653 a Hair
653 a drug effects
653 a Hand Strength
653 a Humans
653 a Hypopituitarism
653 a drug therapy
653 a metabolism
653 a physiopathology
653 a psychology
653 a Insulin-Like Growth Factor I
653 a analysis
653 a Lipoproteins
653 a blood
653 a Middle Aged
653 a Placebos
653 a Quality of Life
653 a Safety
653 a Sex
653 a Sex Hormone-Binding Globulin
653 a analysis
653 a Skin
653 a drug effects
7001 a Burman, Pia4 aut
7001 a Wirén, Lena,d 1941u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine4 aut0 (Swepub:gu)xwirle
7001 a Engström, Britt Edén4 aut
7001 a Nilsson, Anna G,d 19684 aut
7001 a Ottosson, Malin,d 1959u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine4 aut0 (Swepub:gu)xlonnm
7001 a Jonsson, Björn4 aut
7001 a Bengtsson, Bengt-Åke,d 1944u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine4 aut0 (Swepub:gu)xbenbe
7001 a Karlsson, F Anders4 aut
7102 a Göteborgs universitetb Institutionen för invärtesmedicin4 org
7730 t The Journal of clinical endocrinology and metabolismd : The Endocrine Societyg 87:5, s. 2046-52q 87:5<2046-52x 0021-972Xx 1945-7197
8564 u https://academic.oup.com/jcem/article-pdf/87/5/2046/9156128/jcem2046.pdf
8564 8u https://gup.ub.gu.se/publication/226569
8564 8u https://doi.org/10.1210/jcem.87.5.8494

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