19p13.1 is a triple negative-specific breast cancer susceptibility locus

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Fältnamn	Indikatorer	Metadata
000		08948naa a2202161 4500
001		oai:DiVA.org:uu-171130
003		SwePub
008		120315s2012 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:124381503
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1711302 URI
024	7	a https://doi.org/10.1158/0008-5472.CAN-11-33642 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1243815032 URI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Stevens, Kristen N4 aut
245	1 0	a 19p13.1 is a triple negative-specific breast cancer susceptibility locus
264	1	c 2012
338		a print2 rdacarrier
520		a The 19p13.1 breast cancer susceptibility locus is a modifier of breast cancer risk in BRCA1 mutation carriers and is also associated with risk of ovarian cancer. Here we investigated 19p13.1 variation and risk of breast cancer subtypes, defined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2) status, using 48,869 breast cancer cases and 49,787 controls from the Breast Cancer Association Consortium (BCAC). Variants from 19p13.1 were not associated with breast cancer overall or with ER-positive breast cancer but were significantly associated with ER-negative breast cancer risk [rs8170 Odds Ratio (OR)=1.10, 95% Confidence Interval (CI) 1.05 - 1.15, p=3.49 x 10-5] and triple negative (TN) (ER, PR and HER2 negative) breast cancer [rs8170 OR=1.22, 95% CI 1.13 - 1.31, p=2.22 x 10-7]. However, rs8170 was no longer associated with ER-negative breast cancer risk when TN cases were excluded [OR=0.98, 95% CI 0.89 - 1.07, p=0.62]. In addition, a combined analysis of TN cases from BCAC and the Triple Negative Breast Cancer Consortium (TNBCC) (n=3,566) identified a genome-wide significant association between rs8170 and TN breast cancer risk [OR=1.25, 95% CI 1.18 - 1.33, p=3.31 x 10-13]. Thus, 19p13.1 is the first triple negative-specific breast cancer risk locus and the first locus specific to a histological subtype defined by ER, PR, and HER2 to be identified. These findings provide convincing evidence that genetic susceptibility to breast cancer varies by tumor subtype and that triple negative tumors and other subtypes likely arise through distinct etiologic pathways.
700	1	a Fredericksen, Zachary4 aut
700	1	a Vachon, Celine M4 aut
700	1	a Wang, Xianshu4 aut
700	1	a Margolin, Sarau Karolinska Institutet4 aut
700	1	a Lindblom, Annikau Karolinska Institutet4 aut
700	1	a Nevanlinna, Heli4 aut
700	1	a Greco, Dario4 aut
700	1	a Aittomäki, Kristiina4 aut
700	1	a Blomqvist, Carlu Uppsala universitet,Enheten för onkologi4 aut0 (Swepub:uu)carlblom
700	1	a Chang-Claude, Jenny4 aut
700	1	a Vrieling, Alina4 aut
700	1	a Flesch-Janys, Dieter4 aut
700	1	a Sinn, Hans-Peter4 aut
700	1	a Wang-Gohrke, Shan4 aut
700	1	a Nickels, Stefan4 aut
700	1	a Brauch, Hiltrud4 aut
700	1	a Ko, Yon-Dschun4 aut
700	1	a Fischer, Hans-Peter4 aut
700	1	a Network, The Genica4 aut
700	1	a Schmutzler, Rita K4 aut
700	1	a Meindl, Alfons4 aut
700	1	a Bartram, Claus R4 aut
700	1	a Schott, Sarah4 aut
700	1	a Engel, Christoph4 aut
700	1	a Godwin, Andrew K4 aut
700	1	a Weaver, Joellen4 aut
700	1	a Pathak, Harsh B4 aut
700	1	a Sharma, Priyanka4 aut
700	1	a Brenner, Hermann4 aut
700	1	a Muller, Heiko4 aut
700	1	a Arndt, Volker4 aut
700	1	a Stegmaier, Christa4 aut
700	1	a Miron, Penelope4 aut
700	1	a Yannoukakos, Drakoulis4 aut
700	1	a Stavropoulou, Alexandra4 aut
700	1	a Fountzilas, George4 aut
700	1	a Gogas, Helen J4 aut
700	1	a Swann, Ruth4 aut
700	1	a Dwek, Miriam4 aut
700	1	a Perkins, Katherine Anne4 aut
700	1	a Milne, Roger L4 aut
700	1	a Benítez, Javier4 aut
700	1	a Zamora, M Pilar4 aut
700	1	a Ignacio Arias Pérez, José4 aut
700	1	a Bojesen, Stig E4 aut
700	1	a Nielsen, Sune F4 aut
700	1	a Nordestgaard, Borge G4 aut
700	1	a Flyger, Henrik4 aut
700	1	a Guénel, Pascal4 aut
700	1	a Truong, Thérèse4 aut
700	1	a Menegaux, Florence4 aut
700	1	a Cordina-Duverger, Emilie4 aut
700	1	a Burwinkel, Barbara4 aut
700	1	a Marmé, Frederick4 aut
700	1	a Schneeweiss, Andreas4 aut
700	1	a Sohn, Christof4 aut
700	1	a Sawyer, Elinor4 aut
700	1	a Tomlinson, Ian4 aut
700	1	a Kerin, Michael J4 aut
700	1	a Peto, Julian4 aut
700	1	a Johnson, Nichola4 aut
700	1	a Fletcher, Olivia4 aut
700	1	a Dos Santos Silva, Isabel4 aut
700	1	a Fasching, Peter A4 aut
700	1	a Beckmann, Matthias W4 aut
700	1	a Hartmann, Arndt4 aut
700	1	a Ekici, Arif B4 aut
700	1	a Lophatananon, Artitaya4 aut
700	1	a Muir, Kenneth4 aut
700	1	a Puttawibul, Puttisaku Karolinska Institutet4 aut
700	1	a Wiangnon, Surapon4 aut
700	1	a Schmidt, Marjanka K4 aut
700	1	a Broeks, Annegien4 aut
700	1	a Braaf, Linde M4 aut
700	1	a Rosenberg, Efraim H4 aut
700	1	a Hopper, John L4 aut
700	1	a Apicella, Carmel4 aut
700	1	a Park, Daniel J4 aut
700	1	a Southey, Melissa C4 aut
700	1	a Swerdlow, Anthony J4 aut
700	1	a Ashworth, Alan4 aut
700	1	a Orr, Nick4 aut
700	1	a Schoemaker, Minouk J4 aut
700	1	a Anton-Culver, Hoda4 aut
700	1	a Ziogas, Argyrios4 aut
700	1	a Bernstein, Leslie4 aut
700	1	a Clarke Dur, Christina4 aut
700	1	a Shen, Chen-Yang4 aut
700	1	a Yu, Jyh-Cherng4 aut
700	1	a Hsu, Huan-Ming4 aut
700	1	a Hsiung, Chia-Ni4 aut
700	1	a Hamann, Ute4 aut
700	1	a Dünnebier, Thomas4 aut
700	1	a Rüdiger, Thomas4 aut
700	1	a Ulrich Ulmer, Hans4 aut
700	1	a Pharoah, Paul D P4 aut
700	1	a Dunning, Alison M4 aut
700	1	a Humphreys, Manjeet K4 aut
700	1	a Wang, Qin4 aut
700	1	a Cox, Angela4 aut
700	1	a Cross, Simon S4 aut
700	1	a Reed, Malcolm W R4 aut
700	1	a Hall, Per4 aut
700	1	a Czene, Kamilau Karolinska Institutet4 aut
700	1	a Ambrosone, Christine B4 aut
700	1	a Ademuyiwa, Foluso4 aut
700	1	a Hwang, Helena4 aut
700	1	a Eccles, Diana M4 aut
700	1	a Garcia-Closas, Montserrat4 aut
700	1	a Figueroa, Jonine D4 aut
700	1	a Sherman, Mark E4 aut
700	1	a Lissowska, Jolanta4 aut
700	1	a Devilee, Peter4 aut
700	1	a Seynaeve, Caroline4 aut
700	1	a Tollenaar, R A E M4 aut
700	1	a Hooning, Maartje J4 aut
700	1	a Andrulis, Irene L4 aut
700	1	a Knight, Julia A4 aut
700	1	a Glendon, Gord4 aut
700	1	a Mulligan, Anna Marie4 aut
700	1	a Winqvist, Robert4 aut
700	1	a Pylkäs, Katri4 aut
700	1	a Jukkola-Vuorinen, Arja4 aut
700	1	a Grip, Mervi4 aut
700	1	a John, Esther M4 aut
700	1	a Miron, Alexander4 aut
700	1	a Grenaker Alnaes, Grethe4 aut
700	1	a Kristensen, Vessela4 aut
700	1	a Borresen-Dale, Anne-Lise4 aut
700	1	a Giles, Graham G4 aut
700	1	a Baglietto, Laura4 aut
700	1	a McLean, Catriona A4 aut
700	1	a Severi, Gianluca4 aut
700	1	a Kosel, Matthew L4 aut
700	1	a Pankratz, V Shane4 aut
700	1	a Slager, Susan4 aut
700	1	a Olson, Janet E4 aut
700	1	a Radice, Paolo4 aut
700	1	a Peterlongo, Paolo4 aut
700	1	a Manoukian, Siranoush4 aut
700	1	a Barile, Monica4 aut
700	1	a Lambrechts, Diether4 aut
700	1	a Hatse, Sigrid4 aut
700	1	a Dieudonne, Anne-Sophie4 aut
700	1	a Christiaens, Marie-Rose4 aut
700	1	a Chenevix-Trench, Georgia4 aut
700	1	a Investigators, Kconfab4 aut
700	1	a Group, Aocs4 aut
700	1	a Beesley, Jonathan4 aut
700	1	a Chen, Xiaoqing4 aut
700	1	a Mannermaa, Arto4 aut
700	1	a Kosma, Veli-Matti4 aut
700	1	a Hartikainen, Jaana M4 aut
700	1	a Soini, Ylermi4 aut
700	1	a Easton, Douglas F4 aut
700	1	a Couch, Fergus J4 aut
710	2	a Karolinska Institutetb Enheten för onkologi4 org
773	0	t Cancer Researchg 72, s. 1795-q 72<1795-x 0008-5472x 1538-7445
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-171130
856	4 8	u https://doi.org/10.1158/0008-5472.CAN-11-3364
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:124381503

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Av författaren/redakt...: Stevens, Kristen ...; Fredericksen, Za ...; Vachon, Celine M; Wang, Xianshu; Margolin, Sara; Lindblom, Annika; visa fler...; Nevanlinna, Heli; Greco, Dario; Aittomäki, Krist ...; Blomqvist, Carl; Chang-Claude, Je ...; Vrieling, Alina; Flesch-Janys, Di ...; Sinn, Hans-Peter; Wang-Gohrke, Sha ...; Nickels, Stefan; Brauch, Hiltrud; Ko, Yon-Dschun; Fischer, Hans-Pe ...; Network, The Gen ...; Schmutzler, Rita ...; Meindl, Alfons; Bartram, Claus R; Schott, Sarah; Engel, Christoph; Godwin, Andrew K; Weaver, Joellen; Pathak, Harsh B; Sharma, Priyanka; Brenner, Hermann; Muller, Heiko; Arndt, Volker; Stegmaier, Chris ...; Miron, Penelope; Yannoukakos, Dra ...; Stavropoulou, Al ...; Fountzilas, Geor ...; Gogas, Helen J; Swann, Ruth; Dwek, Miriam; Perkins, Katheri ...; Milne, Roger L; Benítez, Javier; Zamora, M Pilar; Ignacio Arias Pé ...; Bojesen, Stig E; Nielsen, Sune F; Nordestgaard, Bo ...; Flyger, Henrik; Guénel, Pascal; Truong, Thérèse; Menegaux, Floren ...; Cordina-Duverger ...; Burwinkel, Barba ...; Marmé, Frederick; Schneeweiss, And ...; Sohn, Christof; Sawyer, Elinor; Tomlinson, Ian; Kerin, Michael J; Peto, Julian; Johnson, Nichola; Fletcher, Olivia; Dos Santos Silva ...; Fasching, Peter ...; Beckmann, Matthi ...; Hartmann, Arndt; Ekici, Arif B; Lophatananon, Ar ...; Muir, Kenneth; Puttawibul, Putt ...; Wiangnon, Surapo ...; Schmidt, Marjank ...; Broeks, Annegien; Braaf, Linde M; Rosenberg, Efrai ...; Hopper, John L; Apicella, Carmel; Park, Daniel J; Southey, Melissa ...; Swerdlow, Anthon ...; Ashworth, Alan; Orr, Nick; Schoemaker, Mino ...; Anton-Culver, Ho ...; Ziogas, Argyrios; Bernstein, Lesli ...; Clarke Dur, Chri ...; Shen, Chen-Yang; Yu, Jyh-Cherng; Hsu, Huan-Ming; Hsiung, Chia-Ni; Hamann, Ute; Dünnebier, Thoma ...; Rüdiger, Thomas; Ulrich Ulmer, Ha ...; Pharoah, Paul D ...; Dunning, Alison ...; Humphreys, Manje ...; Wang, Qin; Cox, Angela; Cross, Simon S; Reed, Malcolm W ...; Hall, Per; Czene, Kamila; Ambrosone, Chris ...; Ademuyiwa, Folus ...; Hwang, Helena; Eccles, Diana M; Garcia-Closas, M ...; Figueroa, Jonine ...; Sherman, Mark E; Lissowska, Jolan ...; Devilee, Peter; Seynaeve, Caroli ...; Tollenaar, R A E ...; Hooning, Maartje ...; Andrulis, Irene ...; Knight, Julia A; Glendon, Gord; Mulligan, Anna M ...; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen ...; Grip, Mervi; John, Esther M; Miron, Alexander; Grenaker Alnaes, ...; Kristensen, Vess ...; Borresen-Dale, A ...; Giles, Graham G; Baglietto, Laura; McLean, Catriona ...; Severi, Gianluca; Kosel, Matthew L; Pankratz, V Shan ...; Slager, Susan; Olson, Janet E; Radice, Paolo; Peterlongo, Paol ...; Manoukian, Siran ...; Barile, Monica; Lambrechts, Diet ...; Hatse, Sigrid; Dieudonne, Anne- ...; Christiaens, Mar ...; Chenevix-Trench, ...; Investigators, K ...; Group, Aocs; Beesley, Jonatha ...; Chen, Xiaoqing; Mannermaa, Arto; Kosma, Veli-Matt ...; Hartikainen, Jaa ...; Soini, Ylermi; Easton, Douglas ...; Couch, Fergus J; visa färre...

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