Search: (WFRF:(Elliott Paul)) pers:(Collins Francis S.) pers:(Abecasis Goncalo R.)
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Twelve type 2 diabe...
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
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Voight, Benjamin F. (author)
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Scott, Laura J. (author)
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Steinthorsdottir, Valgerdur (author)
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show more...
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Morris, Andrew P. (author)
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Dina, Christian (author)
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Welch, Ryan P. (author)
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Zeggini, Eleftheria (author)
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Huth, Cornelia (author)
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Aulchenko, Yurii S. (author)
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Thorleifsson, Gudmar (author)
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McCulloch, Laura J. (author)
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Ferreira, Teresa (author)
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Grallert, Harald (author)
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Amin, Najaf (author)
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Wu, Guanming (author)
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Willer, Cristen J. (author)
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Raychaudhuri, Soumya (author)
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McCarroll, Steve A. (author)
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Langenberg, Claudia (author)
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Hofmann, Oliver M. (author)
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Dupuis, Josee (author)
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Qi, Lu (author)
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Segre, Ayellet V. (author)
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van Hoek, Mandy (author)
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Navarro, Pau (author)
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Ardlie, Kristin (author)
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Balkau, Beverley (author)
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Benediktsson, Rafn (author)
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Bennett, Amanda J. (author)
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Blagieva, Roza (author)
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Boerwinkle, Eric (author)
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Bonnycastle, Lori L. (author)
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Bostrom, Kristina Bengtsson (author)
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Bravenboer, Bert (author)
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Bumpstead, Suzannah (author)
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Burtt, Noisel P. (author)
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Charpentier, Guillaume (author)
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Chines, Peter S. (author)
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Cornelis, Marilyn (author)
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Couper, David J. (author)
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Crawford, Gabe (author)
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Doney, Alex S. F. (author)
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Elliott, Katherine S. (author)
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Elliott, Amanda L. (author)
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Erdos, Michael R. (author)
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Fox, Caroline S. (author)
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Franklin, Christopher S. (author)
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Ganser, Martha (author)
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Gieger, Christian (author)
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Grarup, Niels (author)
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Green, Todd (author)
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Griffin, Simon (author)
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Groves, Christopher J. (author)
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Guiducci, Candace (author)
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Hadjadj, Samy (author)
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Hassanali, Neelam (author)
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Herder, Christian (author)
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Isomaa, Bo (author)
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Jackson, Anne U. (author)
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Johnson, Paul R. V. (author)
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Jorgensen, Torben (author)
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Kao, Wen H. L. (author)
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Klopp, Norman (author)
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Kong, Augustine (author)
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Kraft, Peter (author)
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Kuusisto, Johanna (author)
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Lauritzen, Torsten (author)
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Li, Man (author)
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Lieverse, Aloysius (author)
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Lindgren, Cecilia M. (author)
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- Lyssenko, Valeriya (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Marre, Michel (author)
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Meitinger, Thomas (author)
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Midthjell, Kristian (author)
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Morken, Mario A. (author)
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Narisu, Narisu (author)
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- Nilsson, Peter (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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Owen, Katharine R. (author)
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Payne, Felicity (author)
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Perry, John R. B. (author)
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Petersen, Ann-Kristin (author)
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Platou, Carl (author)
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Proenca, Christine (author)
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Prokopenko, Inga (author)
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Rathmann, Wolfgang (author)
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Rayner, N. William (author)
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Robertson, Neil R. (author)
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Rocheleau, Ghislain (author)
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Roden, Michael (author)
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Sampson, Michael J. (author)
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Saxena, Richa (author)
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Shields, Beverley M. (author)
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Shrader, Peter (author)
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Sigurdsson, Gunnar (author)
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Sparso, Thomas (author)
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Strassburger, Klaus (author)
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Stringham, Heather M. (author)
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Sun, Qi (author)
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Swift, Amy J. (author)
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Thorand, Barbara (author)
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Tichet, Jean (author)
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Tuomi, Tiinamaija (author)
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van Dam, Rob M. (author)
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van Haeften, Timon W. (author)
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van Herpt, Thijs (author)
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van Vliet-Ostaptchouk, Jana V. (author)
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Walters, G. Bragi (author)
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Weedon, Michael N. (author)
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Wijmenga, Cisca (author)
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Witteman, Jacqueline (author)
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Bergman, Richard N. (author)
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Cauchi, Stephane (author)
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Collins, Francis S. (author)
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Gloyn, Anna L. (author)
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- Gyllensten, Ulf (author)
- Uppsala universitet,Institutionen för genetik och patologi
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Hansen, Torben (author)
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Hide, Winston A. (author)
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Hitman, Graham A. (author)
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Hofman, Albert (author)
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Hunter, David J. (author)
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Hveem, Kristian (author)
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Laakso, Markku (author)
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Mohlke, Karen L. (author)
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Morris, Andrew D. (author)
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Palmer, Colin N. A. (author)
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Pramstaller, Peter P. (author)
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Rudan, Igor (author)
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Sijbrands, Eric (author)
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Stein, Lincoln D. (author)
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Tuomilehto, Jaakko (author)
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Uitterlinden, Andre (author)
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Walker, Mark (author)
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Wareham, Nicholas J. (author)
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Watanabe, Richard M. (author)
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Abecasis, Goncalo R. (author)
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Boehm, Bernhard O. (author)
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Campbell, Harry (author)
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Daly, Mark J. (author)
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Hattersley, Andrew T. (author)
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Hu, Frank B. (author)
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Meigs, James B. (author)
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Pankow, James S. (author)
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Pedersen, Oluf (author)
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Wichmann, H-Erich (author)
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Barroso, Ines (author)
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Florez, Jose C. (author)
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Frayling, Timothy M. (author)
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- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Sladek, Rob (author)
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Thorsteinsdottir, Unnur (author)
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Wilson, James F. (author)
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Illig, Thomas (author)
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Froguel, Philippe (author)
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van Duijn, Cornelia M. (author)
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Stefansson, Kari (author)
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Altshuler, David (author)
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Boehnke, Michael (author)
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McCarthy, Mark I. (author)
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(creator_code:org_t)
- 2010-06-27
- 2010
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:7, s. 579-589
- Related links:
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https://cdr.lib.unc....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined P < 5 x 10(-8). These include a second independent signal at the KCNQ1 locus; the first report, to our knowledge, of an X-chromosomal association (near DUSP9); and a further instance of overlap between loci implicated in monogenic and multifactorial forms of diabetes (at HNF1A). The identified loci affect both beta-cell function and insulin action, and, overall, T2D association signals show evidence of enrichment for genes involved in cell cycle regulation. We also show that a high proportion of T2D susceptibility loci harbor independent association signals influencing apparently unrelated complex traits.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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Voight, Benjamin ...
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Scott, Laura J.
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Steinthorsdottir ...
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Morris, Andrew P ...
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Dina, Christian
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Welch, Ryan P.
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show more...
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Zeggini, Elefthe ...
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Huth, Cornelia
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Aulchenko, Yurii ...
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Thorleifsson, Gu ...
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McCulloch, Laura ...
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Ferreira, Teresa
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Grallert, Harald
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Amin, Najaf
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Wu, Guanming
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Willer, Cristen ...
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Raychaudhuri, So ...
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McCarroll, Steve ...
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Langenberg, Clau ...
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Hofmann, Oliver ...
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Dupuis, Josee
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Qi, Lu
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Segre, Ayellet V ...
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van Hoek, Mandy
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Navarro, Pau
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Ardlie, Kristin
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Balkau, Beverley
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Benediktsson, Ra ...
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Bennett, Amanda ...
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Blagieva, Roza
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Boerwinkle, Eric
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Bonnycastle, Lor ...
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Bostrom, Kristin ...
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Bravenboer, Bert
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Bumpstead, Suzan ...
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Burtt, Noisel P.
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Charpentier, Gui ...
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Chines, Peter S.
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Cornelis, Marily ...
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Couper, David J.
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Crawford, Gabe
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Doney, Alex S. F ...
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Elliott, Katheri ...
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Elliott, Amanda ...
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Erdos, Michael R ...
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Fox, Caroline S.
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Franklin, Christ ...
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Ganser, Martha
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Gieger, Christia ...
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Grarup, Niels
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Green, Todd
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Griffin, Simon
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Groves, Christop ...
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Guiducci, Candac ...
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Hadjadj, Samy
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Hassanali, Neela ...
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Herder, Christia ...
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Isomaa, Bo
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Jackson, Anne U.
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Johnson, Paul R. ...
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Jorgensen, Torbe ...
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Kao, Wen H. L.
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Klopp, Norman
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Kong, Augustine
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Kraft, Peter
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Kuusisto, Johann ...
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Lauritzen, Torst ...
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Li, Man
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Lieverse, Aloysi ...
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Lindgren, Cecili ...
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Lyssenko, Valeri ...
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Marre, Michel
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Meitinger, Thoma ...
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Midthjell, Krist ...
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Morken, Mario A.
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Narisu, Narisu
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Nilsson, Peter
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Owen, Katharine ...
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Payne, Felicity
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Perry, John R. B ...
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Petersen, Ann-Kr ...
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Platou, Carl
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Proenca, Christi ...
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Prokopenko, Inga
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Rathmann, Wolfga ...
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Rayner, N. Willi ...
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Robertson, Neil ...
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Rocheleau, Ghisl ...
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Roden, Michael
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Sampson, Michael ...
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Saxena, Richa
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Shields, Beverle ...
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Shrader, Peter
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Sigurdsson, Gunn ...
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Sparso, Thomas
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Strassburger, Kl ...
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Stringham, Heath ...
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Sun, Qi
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Swift, Amy J.
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Thorand, Barbara
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Tichet, Jean
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Tuomi, Tiinamaij ...
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van Dam, Rob M.
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van Haeften, Tim ...
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van Herpt, Thijs
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van Vliet-Ostapt ...
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Walters, G. Brag ...
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Weedon, Michael ...
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Wijmenga, Cisca
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Witteman, Jacque ...
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Bergman, Richard ...
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Cauchi, Stephane
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Collins, Francis ...
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Gloyn, Anna L.
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Gyllensten, Ulf
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Hansen, Torben
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Hide, Winston A.
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Hitman, Graham A ...
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Hofman, Albert
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Hunter, David J.
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Hveem, Kristian
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Laakso, Markku
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Mohlke, Karen L.
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Morris, Andrew D ...
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Palmer, Colin N. ...
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Pramstaller, Pet ...
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Rudan, Igor
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Sijbrands, Eric
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Stein, Lincoln D ...
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Tuomilehto, Jaak ...
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Uitterlinden, An ...
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Walker, Mark
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Wareham, Nichola ...
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Watanabe, Richar ...
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Abecasis, Goncal ...
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Boehm, Bernhard ...
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Campbell, Harry
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Daly, Mark J.
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Hattersley, Andr ...
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Hu, Frank B.
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Meigs, James B.
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Pankow, James S.
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Pedersen, Oluf
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Wichmann, H-Eric ...
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Barroso, Ines
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Florez, Jose C.
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Frayling, Timoth ...
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Groop, Leif
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Sladek, Rob
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Thorsteinsdottir ...
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Wilson, James F.
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Illig, Thomas
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Froguel, Philipp ...
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van Duijn, Corne ...
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Stefansson, Kari
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Altshuler, David
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Boehnke, Michael
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McCarthy, Mark I ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Other Clinical M ...
- Articles in the publication
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Nature Genetics
- By the university
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Uppsala University
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Lund University