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Ghrelin expression ...
Ghrelin expression is associated with a favorable outcome in male breast cancer
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- Grönberg, Malin, 1980- (author)
- Uppsala University,Uppsala universitet,Onkologisk endokrinologi
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- Nilsson, Cecilia (author)
- Vastmanland Cty Hosp, Ctr Clin Res, Vasteras, Sweden,Västmanland Hospital
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- Markholm, Ida (author)
- Lund Univ, Dept Clin Sci, Div Oncol & Pathol, Lund, Sweden;Lund Univ, CREATE Hlth Strateg Ctr Translat Canc Res, Lund, Sweden,Lund University
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- Hedenfalk, Ingrid (author)
- Lund University,Lunds universitet,Bröst- och ovarialcancer,Forskargrupper vid Lunds universitet,Breast and Ovarian Cancer Genomics,Lund University Research Groups
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- Blomqvist, Carl (author)
- Univ Helsinki, Dept Oncol, Helsinki, Finland;Orebro Univ Hosp, Dept Oncol, Orebro, Sweden,University of Helsinki,Örebro University Hospital
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- Holmberg, Lars (author)
- Uppsala University,Uppsala universitet,Endokrinkirurgi,Kings Coll London, Fac Life Sci & Med, London, England,King's College London
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- Tiensuu Janson, Eva (author)
- Uppsala University,Uppsala universitet,Onkologisk endokrinologi
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- Fjällskog, Marie-Louise (author)
- Uppsala University,Uppsala universitet,Onkologisk endokrinologi
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(creator_code:org_t)
- 2018-09-11
- 2018
- English.
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In: Scientific Reports. - : NATURE PUBLISHING GROUP. - 2045-2322. ; 8
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Ghrelin and obestatin are two gastrointestinal peptides, derived from a common precursor. Expression of both peptides have been found in breast cancer tissue and ghrelin has been associated with breast cancer development. Ghrelin expression is associated with longer survival in women diagnosed with invasive and node negative breast cancer. The clinical implications of the peptide expression in male breast cancer are unclear. The aim of this study was to investigate the role and potential clinical value of ghrelin and obestatin in male breast cancer. A tissue microarray of invasive male breast cancer specimens from 197 patients was immunostained with antibodies versus the two peptides. The expression of the peptides was correlated to previously known prognostic factors in breast cancer and to the outcome. No strong correlations were found between ghrelin or obestatin expression and other known prognostic factors. Only ghrelin expression was statistically significantly correlated to breast cancer-specific survival (HR 0.39, 95% CI 0.18-0.83) in univariate analyses and in multivariate models, adjusted for tumor size and node status (HR 0.38, 95% CI 0.17-0.87). HR for obestatin was 0.38 (95% CI 0.11-1.24). Ghrelin is a potential prognostic factor for breast cancer death in male breast cancer. Patients with tumors expressing ghrelin have a 2.5-fold lower risk for breast cancer death than those lacking ghrelin expression. Drugs targeting ghrelin are currently being investigated in clinical studies treating metabolic or nutritional disorders. Ghrelin should be further evaluated in forthcoming studies as a prognostic marker with the aim to be included in decision algorithms.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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