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Atlas of prostate c...
Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation
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Gusev, A (author)
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Shi, H (author)
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Kichaev, G (author)
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show more...
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Pomerantz, M (author)
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Li, F (author)
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Long, HW (author)
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Ingles, SA (author)
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Kittles, RA (author)
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Strom, SS (author)
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Rybicki, BA (author)
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Nemesure, B (author)
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Isaacs, WB (author)
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Zheng, W (author)
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Pettaway, CA (author)
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Yeboah, ED (author)
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Tettey, Y (author)
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Biritwum, RB (author)
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Adjei, AA (author)
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Tay, E (author)
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Truelove, A (author)
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Niwa, S (author)
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Chokkalingam, AP (author)
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John, EM (author)
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- Murphy, AB (author)
- Karolinska Institutet
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Signorello, LB (author)
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Carpten, J (author)
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Leske, MC (author)
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Wu, SY (author)
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- Johansson, Mattias (author)
- Umeå universitet,Enheten för biobanksforskning,Urologi och andrologi
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Neslund-Dudas, C (author)
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Hsing, AW (author)
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Chu, L (author)
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Goodman, PJ (author)
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Klein, EA (author)
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Witte, JS (author)
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Casey, G (author)
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Kaggwa, S (author)
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Cook, MB (author)
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Stram, DO (author)
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Blot, WJ (author)
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Eeles, RA (author)
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Easton, D (author)
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Kote-Jarai, Z (author)
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Al Olama, AA (author)
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Benlloch, S (author)
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Muir, K (author)
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Giles, GG (author)
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Southey, MC (author)
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Fitzgerald, LM (author)
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- Gronberg, H (author)
- Karolinska Institutet
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- Wiklund, F (author)
- Karolinska Institutet
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- Aly, M (author)
- Karolinska Institutet
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Henderson, BE (author)
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Schleutker, J (author)
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Wahlfors, T (author)
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Tammela, TLJ (author)
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Nordestgaard, BG (author)
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Key, TJ (author)
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Travis, RC (author)
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Neal, DE (author)
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Donovan, JL (author)
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Hamdy, FC (author)
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Pharoah, P (author)
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Pashayan, N (author)
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Khaw, KT (author)
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Stanford, JL (author)
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Thibodeau, SN (author)
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McDonnell, SK (author)
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Schaid, DJ (author)
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Maier, C (author)
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Vogel, W (author)
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Luedeke, M (author)
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Herkommer, K (author)
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Kibel, AS (author)
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Cybulski, C (author)
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Wokolorczyk, D (author)
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Kluzniak, W (author)
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Cannon-Albright, L (author)
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Teerlink, C (author)
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Brenner, H (author)
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Dieffenbach, AK (author)
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Arndt, V (author)
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Park, JY (author)
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Sellers, TA (author)
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Lin, HY (author)
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Slavov, C (author)
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Kaneva, R (author)
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Mitev, V (author)
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Batra, J (author)
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Spurdle, A (author)
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- Clements, JA (author)
- Karolinska Institutet
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Teixeira, MR (author)
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Pandha, H (author)
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Michael, A (author)
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Paulo, P (author)
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Maia, S (author)
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Kierzek, A (author)
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Conti, DV (author)
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Albanes, D (author)
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Berg, C (author)
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Berndt, SI (author)
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Campa, D (author)
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Crawford, ED (author)
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Diver, WR (author)
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Gapstur, SM (author)
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Gaziano, JM (author)
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Giovannucci, E (author)
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Hoover, R (author)
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Hunter, DJ (author)
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Johansson, M (author)
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Kraft, P (author)
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Le Marchand, L (author)
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Lindstrom, S (author)
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Navarro, C (author)
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Overvad, K (author)
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Riboli, E (author)
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Siddiq, A (author)
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Stevens, VL (author)
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Trichopoulos, D (author)
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Vineis, P (author)
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Yeager, M (author)
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Trynka, G (author)
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Raychaudhuri, S (author)
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Schumacher, FR (author)
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Price, AL (author)
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Freedman, ML (author)
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Haiman, CA (author)
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Pasaniuc, B (author)
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Cook, M (author)
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Guy, M (author)
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Govindasami, K (author)
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Leongamornlert, D (author)
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Sawyer, EJ (author)
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Wilkinson, R (author)
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Saunders, EJ (author)
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Tymrakiewicz, M (author)
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Dadaev, T (author)
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Morgan, A (author)
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Fisher, C (author)
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Hazel, S (author)
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Livni, N (author)
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Lophatananon, A (author)
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Pedersen, J (author)
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Hopper, JL (author)
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- Adolfson, J (author)
- Karolinska Institutet
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Stattin, P (author)
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Johansson, JE (author)
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Cavalli-Bjoerkman, C (author)
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Karlsson, A (author)
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Broms, M (author)
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Auvinen, A (author)
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Kujala, P (author)
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Maeaettaenen, L (author)
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Murtola, T (author)
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Taari, K (author)
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Weischer, M (author)
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Nielsen, SF (author)
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Klarskov, P (author)
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Roder, A (author)
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Iversen, P (author)
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Wallinder, H (author)
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Gustafsson, S (author)
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Cox, A (author)
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Brown, P (author)
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George, A (author)
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Marsden, G (author)
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Lane, A (author)
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Davis, M (author)
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Zheng, W (author)
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Signorello, LB (author)
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Blot, WJ (author)
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Tillmans, L (author)
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Riska, S (author)
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Wang, L (author)
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Rinckleb, A (author)
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Lubiski, J (author)
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Stegmaier, C (author)
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Pow-Sang, J (author)
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Park, H (author)
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Radlein, S (author)
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Rincon, M (author)
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Haley, J (author)
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Zachariah, B (author)
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Kachakova, D (author)
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Popov, E (author)
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Mitkova, A (author)
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Vlahova, A (author)
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Dikov, T (author)
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Christova, S (author)
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Heathcote, P (author)
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Wood, G (author)
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Malone, G (author)
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Saunders, P (author)
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Eckert, A (author)
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Yeadon, T (author)
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Kerr, K (author)
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Collins, A (author)
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Turner, M (author)
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Srinivasan, S (author)
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Kedda, MA (author)
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Alexander, K (author)
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Omara, T (author)
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Wu, HH (author)
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Henrique, R (author)
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Pinto, P (author)
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Santos, J (author)
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Barros-Silva, J (author)
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(creator_code:org_t)
- 2016-04-07
- 2016
- English.
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7, s. 10979-
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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http://kipublication...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Although genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data from 59,089 men of European and African American ancestries combined with cell-type-specific epigenetic data to build a genomic atlas of single-nucleotide polymorphism (SNP) heritability in PrCa. We find significant differences in heritability between variants in prostate-relevant epigenetic marks defined in normal versus tumour tissue as well as between tissue and cell lines. The majority of SNP heritability lies in regions marked by H3k27 acetylation in prostate adenoc7arcinoma cell line (LNCaP) or by DNaseI hypersensitive sites in cancer cell lines. We find a high degree of similarity between European and African American ancestries suggesting a similar genetic architecture from common variation underlying PrCa risk. Our findings showcase the power of integrating functional annotation with genetic data to understand the genetic basis of PrCa.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Gusev, A
-
Shi, H
-
Kichaev, G
-
Pomerantz, M
-
Li, F
-
Long, HW
-
show more...
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Ingles, SA
-
Kittles, RA
-
Strom, SS
-
Rybicki, BA
-
Nemesure, B
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Isaacs, WB
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Zheng, W
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Pettaway, CA
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Yeboah, ED
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Tettey, Y
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Biritwum, RB
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Adjei, AA
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Tay, E
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Truelove, A
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Niwa, S
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Chokkalingam, AP
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John, EM
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Murphy, AB
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Signorello, LB
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Carpten, J
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Leske, MC
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Wu, SY
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Johansson, Matti ...
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Neslund-Dudas, C
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Hsing, AW
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Chu, L
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Goodman, PJ
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Klein, EA
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Witte, JS
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Casey, G
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Kaggwa, S
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Cook, MB
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Stram, DO
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Blot, WJ
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Eeles, RA
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Easton, D
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Kote-Jarai, Z
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Al Olama, AA
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Benlloch, S
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Muir, K
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Giles, GG
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Southey, MC
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Fitzgerald, LM
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Gronberg, H
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Wiklund, F
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Aly, M
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Henderson, BE
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Schleutker, J
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Wahlfors, T
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Tammela, TLJ
-
Nordestgaard, BG
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Key, TJ
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Travis, RC
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Neal, DE
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Donovan, JL
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Hamdy, FC
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Pharoah, P
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Pashayan, N
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Khaw, KT
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Stanford, JL
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Thibodeau, SN
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McDonnell, SK
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Schaid, DJ
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Maier, C
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Vogel, W
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Luedeke, M
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Herkommer, K
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Kibel, AS
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Cybulski, C
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Wokolorczyk, D
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Kluzniak, W
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Cannon-Albright, ...
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Teerlink, C
-
Brenner, H
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Dieffenbach, AK
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Arndt, V
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Park, JY
-
Sellers, TA
-
Lin, HY
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Slavov, C
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Kaneva, R
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Mitev, V
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Batra, J
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Spurdle, A
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Clements, JA
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Teixeira, MR
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Pandha, H
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Michael, A
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Paulo, P
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Maia, S
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Kierzek, A
-
Conti, DV
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Albanes, D
-
Berg, C
-
Berndt, SI
-
Campa, D
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Crawford, ED
-
Diver, WR
-
Gapstur, SM
-
Gaziano, JM
-
Giovannucci, E
-
Hoover, R
-
Hunter, DJ
-
Johansson, M
-
Kraft, P
-
Le Marchand, L
-
Lindstrom, S
-
Navarro, C
-
Overvad, K
-
Riboli, E
-
Siddiq, A
-
Stevens, VL
-
Trichopoulos, D
-
Vineis, P
-
Yeager, M
-
Trynka, G
-
Raychaudhuri, S
-
Schumacher, FR
-
Price, AL
-
Freedman, ML
-
Haiman, CA
-
Pasaniuc, B
-
Cook, M
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Guy, M
-
Govindasami, K
-
Leongamornlert, ...
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Sawyer, EJ
-
Wilkinson, R
-
Saunders, EJ
-
Tymrakiewicz, M
-
Dadaev, T
-
Morgan, A
-
Fisher, C
-
Hazel, S
-
Livni, N
-
Lophatananon, A
-
Pedersen, J
-
Hopper, JL
-
Adolfson, J
-
Stattin, P
-
Johansson, JE
-
Cavalli-Bjoerkma ...
-
Karlsson, A
-
Broms, M
-
Auvinen, A
-
Kujala, P
-
Maeaettaenen, L
-
Murtola, T
-
Taari, K
-
Weischer, M
-
Nielsen, SF
-
Klarskov, P
-
Roder, A
-
Iversen, P
-
Wallinder, H
-
Gustafsson, S
-
Cox, A
-
Brown, P
-
George, A
-
Marsden, G
-
Lane, A
-
Davis, M
-
Tillmans, L
-
Riska, S
-
Wang, L
-
Rinckleb, A
-
Lubiski, J
-
Stegmaier, C
-
Pow-Sang, J
-
Park, H
-
Radlein, S
-
Rincon, M
-
Haley, J
-
Zachariah, B
-
Kachakova, D
-
Popov, E
-
Mitkova, A
-
Vlahova, A
-
Dikov, T
-
Christova, S
-
Heathcote, P
-
Wood, G
-
Malone, G
-
Saunders, P
-
Eckert, A
-
Yeadon, T
-
Kerr, K
-
Collins, A
-
Turner, M
-
Srinivasan, S
-
Kedda, MA
-
Alexander, K
-
Omara, T
-
Wu, HH
-
Henrique, R
-
Pinto, P
-
Santos, J
-
Barros-Silva, J
-
show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Nature communica ...
- By the university
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Karolinska Institutet
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Umeå University