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Diet quality and ri...
Diet quality and risk and severity of COVID-19 : a prospective cohort study
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- Merino, Jordi (author)
- Harvard Medical School,Massachusetts General Hospital,Broad Institute
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- Joshi, Amit D. (author)
- Massachusetts General Hospital
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- Nguyen, Long H. (author)
- Massachusetts General Hospital,Harvard University
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- Leeming, Emily R. (author)
- King's College London
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- Mazidi, Mohsen (author)
- King's College London
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- Drew, David A. (author)
- Massachusetts General Hospital
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- Gibson, Rachel (author)
- King's College London
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- Graham, Mark S. (author)
- King's College London
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- Lo, Chun Han (author)
- Massachusetts General Hospital
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- Capdevila, Joan (author)
- Zoe Global Limited
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- Murray, Benjamin (author)
- King's College London
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- Hu, Christina (author)
- Zoe Global Limited
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- Selvachandran, Somesh (author)
- Zoe Global Limited
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- Hammers, Alexander (author)
- King's College London
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- Bhupathiraju, Shilpa N. (author)
- Harvard University,Harvard Medical School
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- Sharma, Shreela V. (author)
- University of Texas
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- Sudre, Carole (author)
- King's College London
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- Astley, Christina M. (author)
- Broad Institute,Harvard Medical School
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- Chavarro, Jorge E. (author)
- Brigham and Women's Hospital / Harvard Medical School,Harvard University
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- Kwon, Sohee (author)
- Massachusetts General Hospital
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- Ma, Wenjie (author)
- Massachusetts General Hospital
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- Menni, Cristina (author)
- King's College London
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- Willett, Walter C. (author)
- Brigham and Women's Hospital / Harvard Medical School,Harvard University
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- Ourselin, Sebastien (author)
- King's College London
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- Steves, Claire J. (author)
- King's College London
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- Wolf, Jonathan (author)
- Zoe Global Limited
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- Franks, Paul W. (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Harvard T.H. Chan School of Public Health
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- Spector, Timothy D. (author)
- King's College London
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- Berry, Sarah (author)
- King's College London
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- Chan, Andrew T. (author)
- Massachusetts General Hospital,Harvard University
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(creator_code:org_t)
- 2021-09-06
- 2021
- English 9 s.
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In: Gut. - : BMJ. - 1468-3288 .- 0017-5749. ; 70:11, s. 2096-2104
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http://dx.doi.org/10... (free)
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https://gut.bmj.com/...
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https://doi.org/10.1...
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Abstract
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- OBJECTIVE: Poor metabolic health and unhealthy lifestyle factors have been associated with risk and severity of COVID-19, but data for diet are lacking. We aimed to investigate the association of diet quality with risk and severity of COVID-19 and its interaction with socioeconomic deprivation. DESIGN: We used data from 592 571 participants of the smartphone-based COVID-19 Symptom Study. Diet information was collected for the prepandemic period using a short food frequency questionnaire, and diet quality was assessed using a healthful Plant-Based Diet Score, which emphasises healthy plant foods such as fruits or vegetables. Multivariable Cox models were fitted to calculate HRs and 95% CIs for COVID-19 risk and severity defined using a validated symptom-based algorithm or hospitalisation with oxygen support, respectively. RESULTS: Over 3 886 274 person-months of follow-up, 31 815 COVID-19 cases were documented. Compared with individuals in the lowest quartile of the diet score, high diet quality was associated with lower risk of COVID-19 (HR 0.91; 95% CI 0.88 to 0.94) and severe COVID-19 (HR 0.59; 95% CI 0.47 to 0.74). The joint association of low diet quality and increased deprivation on COVID-19 risk was higher than the sum of the risk associated with each factor alone (Pinteraction=0.005). The corresponding absolute excess rate per 10 000 person/months for lowest vs highest quartile of diet score was 22.5 (95% CI 18.8 to 26.3) among persons living in areas with low deprivation and 40.8 (95% CI 31.7 to 49.8) among persons living in areas with high deprivation. CONCLUSIONS: A diet characterised by healthy plant-based foods was associated with lower risk and severity of COVID-19. This association may be particularly evident among individuals living in areas with higher socioeconomic deprivation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- COVID-19
- diet
- dietary factors
- infectious disease
Publication and Content Type
- art (subject category)
- ref (subject category)
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Gut
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- By the author/editor
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Merino, Jordi
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Joshi, Amit D.
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Nguyen, Long H.
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Leeming, Emily R ...
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Mazidi, Mohsen
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Drew, David A.
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show more...
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Gibson, Rachel
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Graham, Mark S.
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Lo, Chun Han
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Capdevila, Joan
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Murray, Benjamin
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Hu, Christina
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Selvachandran, S ...
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Hammers, Alexand ...
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Bhupathiraju, Sh ...
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Sharma, Shreela ...
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Sudre, Carole
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Astley, Christin ...
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Chavarro, Jorge ...
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Kwon, Sohee
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Ma, Wenjie
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Menni, Cristina
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Willett, Walter ...
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Ourselin, Sebast ...
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Steves, Claire J ...
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Wolf, Jonathan
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Franks, Paul W.
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Spector, Timothy ...
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Berry, Sarah
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Chan, Andrew T.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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Gut
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Lund University