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Plasma phyto-oestro...
Plasma phyto-oestrogens and prostate cancer in the European prospective investigation into cancer and nutrition
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Travis, R C (author)
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Spencer, E A (author)
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Allen, N E (author)
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Appleby, P N (author)
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Roddam, A W (author)
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Overvad, K (author)
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Johnsen, N F (author)
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Olsen, A (author)
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Kaaks, R (author)
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Linseisen, J (author)
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Boeing, H (author)
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Nöthlings, U (author)
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Bueno-de-Mesquita, H B (author)
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Ros, M M (author)
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Sacerdote, C (author)
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Palli, D (author)
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Tumino, R (author)
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Berrino, F (author)
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Trichopoulou, A (author)
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Dilis, V (author)
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Trichopoulos, D (author)
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Chirlaque, M-D (author)
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Ardanaz, E (author)
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Larranaga, N (author)
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Gonzalez, C (author)
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Suárez, L R (author)
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Sánchez, M-J (author)
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Bingham, S (author)
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Khaw, K-T (author)
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- Hallmans, G (author)
- Umeå universitet,Näringsforskning
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- Stattin, P (author)
- Umeå universitet,Urologi och andrologi
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Rinaldi, S (author)
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Slimani, N (author)
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Jenab, M (author)
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Riboli, E (author)
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Key, T J (author)
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(creator_code:org_t)
- 2009-05-12
- 2009
- English.
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In: British journal of cancer. - : Springer Science and Business Media LLC. - 1532-1827 .- 0007-0920. ; 100:11, s. 1817-1823
- Related links:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- We examined plasma concentrations of phyto-oestrogens in relation to risk for subsequent prostate cancer in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition. Concentrations of isoflavones genistein, daidzein and equol, and that of lignans enterolactone and enterodiol, were measured in plasma samples for 950 prostate cancer cases and 1042 matched control participants. Relative risks (RRs) for prostate cancer in relation to plasma concentrations of these phyto-oestrogens were estimated by conditional logistic regression. Higher plasma concentrations of genistein were associated with lower risk of prostate cancer: RR among men in the highest vs the lowest fifth, 0.71 (95% confidence interval (CI) 0.53-0.96, P trend=0.03). After adjustment for potential confounders this RR was 0.74 (95% CI 0.54-1.00, P trend=0.05). No statistically significant associations were observed for circulating concentrations of daidzein, equol, enterolactone or enterodiol in relation to overall risk for prostate cancer. There was no evidence of heterogeneity in these results by age at blood collection or country of recruitment, nor by cancer stage or grade. These results suggest that higher concentrations of circulating genistein may reduce the risk of prostate cancer but do not support an association with plasma lignans.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Travis, R C
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Spencer, E A
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Allen, N E
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Appleby, P N
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Roddam, A W
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Overvad, K
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show more...
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Johnsen, N F
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Olsen, A
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Kaaks, R
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Linseisen, J
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Boeing, H
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Nöthlings, U
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Bueno-de-Mesquit ...
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Ros, M M
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Sacerdote, C
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Palli, D
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Tumino, R
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Berrino, F
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Trichopoulou, A
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Dilis, V
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Trichopoulos, D
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Chirlaque, M-D
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Ardanaz, E
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Larranaga, N
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Gonzalez, C
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Suárez, L R
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Sánchez, M-J
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Bingham, S
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Khaw, K-T
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Hallmans, G
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Stattin, P
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Rinaldi, S
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Slimani, N
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Jenab, M
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Riboli, E
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Key, T J
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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British journal ...
- By the university
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Umeå University