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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005826naa a2200805 4500
001oai:DiVA.org:uu-336327
003SwePub
008171213s2016 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-122122
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3363272 URI
0247 a https://doi.org/10.1016/j.eururo.2016.03.0292 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1221222 URI
040 a (SwePub)uud (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Price, Alison J4 aut
2451 0a Circulating Folate and Vitamin B12 and Risk of Prostate Cancer :b A Collaborative Analysis of Individual Participant Data from Six Cohorts Including 6875 Cases and 8104 Controls.
264 1b Elsevier BV,c 2016
338 a print2 rdacarrier
520 a BACKGROUND: Folate and vitamin B12 are essential for maintaining DNA integrity and may influence prostate cancer (PCa) risk, but the association with clinically relevant, advanced stage, and high-grade disease is unclear.OBJECTIVE: To investigate the associations between circulating folate and vitamin B12 concentrations and risk of PCa overall and by disease stage and grade.DESIGN, SETTING, AND PARTICIPANTS: A study was performed with a nested case-control design based on individual participant data from six cohort studies including 6875 cases and 8104 controls; blood collection from 1981 to 2008, and an average follow-up of 8.9 yr (standard deviation 7.3). Odds ratios (ORs) of incident PCa by study-specific fifths of circulating folate and vitamin B12 were calculated using multivariable adjusted conditional logistic regression.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Incident PCa and subtype by stage and grade.RESULTS AND LIMITATIONS: Higher folate and vitamin B12 concentrations were associated with a small increase in risk of PCa (ORs for the top vs bottom fifths were 1.13 [95% confidence interval (CI), 1.02-1.26], ptrend=0.018, for folate and 1.12 [95% CI, 1.01-1.25], ptrend=0.017, for vitamin B12), with no evidence of heterogeneity between studies. The association with folate varied by tumour grade (pheterogeneity<0.001); higher folate concentration was associated with an elevated risk of high-grade disease (OR for the top vs bottom fifth: 2.30 [95% CI, 1.28-4.12]; ptrend=0.001), with no association for low-grade disease. There was no evidence of heterogeneity in the association of folate with risk by stage or of vitamin B12 with risk by stage or grade of disease (pheterogeneity>0.05). Use of single blood-sample measurements of folate and B12 concentrations is a limitation.CONCLUSIONS: The association between higher folate concentration and risk of high-grade disease, not evident for low-grade disease, suggests a possible role for folate in the progression of clinically relevant PCa and warrants further investigation.PATIENT SUMMARY: Folate, a vitamin obtained from foods and supplements, is important for maintaining cell health. In this study, however, men with higher blood folate levels were at greater risk of high-grade (more aggressive) prostate cancer compared with men with lower folate levels. Further research is needed to investigate the possible role of folate in the progression of this disease.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
653 a Folate
653 a High grade
653 a Pooled data meta-analysis
653 a Prospective cohort
653 a Prostate cancer
653 a Vitamin B(12)
7001 a Travis, Ruth C4 aut
7001 a Appleby, Paul N4 aut
7001 a Albanes, Demetrius4 aut
7001 a Barricarte Gurrea, Aurelio4 aut
7001 a Bjørge, Tone4 aut
7001 a Bueno-de-Mesquita, H Bas4 aut
7001 a Chen, Chu4 aut
7001 a Donovan, Jenny4 aut
7001 a Gislefoss, Randi4 aut
7001 a Goodman, Gary4 aut
7001 a Gunter, Marc4 aut
7001 a Hamdy, Freddie C4 aut
7001 a Johansson, Mattiasu Umeå universitet,Enheten för biobanksforskning,International Agency for Research on Cancer, Lyon, France4 aut0 (Swepub:umu)masmas97
7001 a King, Irena B4 aut
7001 a Kühn, Tilman4 aut
7001 a Männistö, Satu4 aut
7001 a Martin, Richard M4 aut
7001 a Meyer, Klaus4 aut
7001 a Neal, David E4 aut
7001 a Neuhouser, Marian L4 aut
7001 a Nygård, Ottar4 aut
7001 a Stattin, Päru Umeå universitet,Uppsala universitet,Urologkirurgi,Urologi och andrologi4 aut0 (Swepub:umu)past0003
7001 a Tell, Grethe S4 aut
7001 a Trichopoulou, Antonia4 aut
7001 a Tumino, Rosario4 aut
7001 a Ueland, Per Magne4 aut
7001 a Ulvik, Arve4 aut
7001 a de Vogel, Stefan4 aut
7001 a Vollset, Stein Emil4 aut
7001 a Weinstein, Stephanie J4 aut
7001 a Key, Timothy J4 aut
7001 a Allen, Naomi E4 aut
7102 a Umeå universitetb Enheten för biobanksforskning4 org
7730 t European Urologyd : Elsevier BVg 70:6, s. 941-951q 70:6<941-951x 0302-2838x 1873-7560
8564 u http://www.europeanurology.com/article/S0302283816003791/pdf
8564 u https://doi.org/10.1016/j.eururo.2016.03.029y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:937401/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-336327
8564 8u https://doi.org/10.1016/j.eururo.2016.03.029
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-122122

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