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Consumption of meat...
Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores : a meta-analysis of 50,345 Caucasians
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Fretts, Amanda M. (author)
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Follis, Jack L. (author)
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Nettleton, Jennifer A. (author)
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show more...
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Lemaitre, Rozenn N. (author)
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Ngwa, Julius S. (author)
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Wojczynski, Mary K. (author)
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Kalafati, Ioanna Panagiota (author)
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Varga, Tibor V. (author)
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Frazier-Wood, Alexis C. (author)
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Houston, Denise K. (author)
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Lahti, Jari (author)
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- Ericson, Ulrika (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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van den Hooven, Edith H. (author)
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Mikkilae, Vera (author)
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Kiefte-de Jong, Jessica C. (author)
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Mozaffarian, Dariush (author)
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Rice, Kenneth (author)
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- Renström, Frida (author)
- Umeå universitet,Enheten för biobanksforskning,Näringsforskning,Department of Clinical Sciences Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden
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North, Kari E. (author)
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McKeown, Nicola M. (author)
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Feitosa, Mary F. (author)
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Kanoni, Stavroula (author)
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Smith, Caren E. (author)
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Garcia, Melissa E. (author)
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Tiainen, Anna-Maija (author)
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- Sonestedt, Emily (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Nutritionsepidemiologi,Diabetes - Cardiovascular Disease,Lund University Research Groups,Nutrition Epidemiology
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Manichaikul, Ani (author)
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van Rooij, Frank J. A. (author)
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Dimitriou, Maria (author)
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Raitakari, Olli (author)
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Pankow, James S. (author)
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Djousse, Luc (author)
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Province, Michael A. (author)
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Hu, Frank B. (author)
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Lai, Chao-Qiang (author)
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Keller, Margaux F. (author)
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Peraelae, Mia-Maria (author)
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Rotter, Jerome I. (author)
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Hofman, Albert (author)
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Graff, Misa (author)
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Kaehoenen, Mika (author)
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Mukamal, Kenneth (author)
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- Johansson, Ingegerd (author)
- Umeå universitet,Institutionen för odontologi,Näringsforskning,Enheten för biobanksforskning
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Ordovas, Jose M. (author)
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Liu, Yongmei (author)
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Maennistoe, Satu (author)
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Uitterlinden, Andre G. (author)
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Deloukas, Panos (author)
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Seppaelae, Ilkka (author)
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Psaty, Bruce M. (author)
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Cupples, L. Adrienne (author)
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Borecki, Ingrid B. (author)
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- Franks, Paul W. (author)
- Umeå universitet,Medicin,Department of Clinical Sciences Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden; Department of Nutrition, Harvard School of Public Health, Boston, MA
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Arnett, Donna K. (author)
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Nalls, Mike A. (author)
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Eriksson, Johan G. (author)
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- Orho-Melander, Marju (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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Franco, Oscar H. (author)
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Lehtimaeki, Terho (author)
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Dedoussis, George V. (author)
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Meigs, James B. (author)
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Siscovick, David S. (author)
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(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- English.
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In: American Journal of Clinical Nutrition. - : Elsevier BV. - 0002-9165 .- 1938-3207. ; 102:5, s. 1266-1278
- Related links:
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https://academic.oup...
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- Background: Recent studies suggest that meat intake is associated with diabetes-related phenotypes. However, whether the associations of meat intake and glucose and insulin homeostasis are modified by genes related to glucose and insulin is unknown. Objective: We investigated the associations of meat intake and the interaction of meat with genotype on fasting glucose and insulin concentrations in Caucasians free of diabetes mellitus. Design: Fourteen studies that are part of the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium participated in the analysis. Data were provided for up to 50,345 participants. Using linear regression within studies and a fixed-effects meta-analysis across studies, we examined l) the associations of processed meat and unprocessed red meat intake with fasting glucose and insulin concentrations; and 2) the interactions of processed meat and unprocessed red meat with genetic risk score related to fasting glucose or insulin resistance on fasting glucose and insulin concentrations. Results: Processed meat was associated with higher fasting glucose, and unprocessed red meat was associated with both higher fasting glucose and fasting insulin concentrations after adjustment for potential confounders [not including body mass index (BMI)]. For every additional 50-g serving of processed meat per day, fasting glucose was 0.021 mmol/L (95% CI: 0.011, 0.030 mmol/L) higher. Every additional 100-g serving of unprocessed red meat per day was associated with a 0.037-mmol/L (95% CI: 0.023, 0.051-mmol/L) higher fasting glucose concentration and a 0.049-1n-pmon (95% CI: 0.035, 0.063-1n-pmol/L) higher fasting insulin concentration. After additional adjustment for BMI, observed associations were attenuated and no longer statistically significant. The association of processed meat and fasting insulin did not reach statistical significance after correction for multiple comparisons. Observed associations were not modified by genetic loci known to influence fasting glucose or insulin resistance. Conclusion: The association of higher fasting glucose and insulin concentrations with meat consumption was not modified by an index of glucose- and insulin-related single-nucleotide polymorphisms.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- gene-diet interaction
- glucose
- insulin
- meat intake
- diet
- meta-analysis
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Fretts, Amanda M ...
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Follis, Jack L.
-
Nettleton, Jenni ...
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Lemaitre, Rozenn ...
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Ngwa, Julius S.
-
Wojczynski, Mary ...
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show more...
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Kalafati, Ioanna ...
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Varga, Tibor V.
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Frazier-Wood, Al ...
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Houston, Denise ...
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Lahti, Jari
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Ericson, Ulrika
-
van den Hooven, ...
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Mikkilae, Vera
-
Kiefte-de Jong, ...
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Mozaffarian, Dar ...
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Rice, Kenneth
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Renström, Frida
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North, Kari E.
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McKeown, Nicola ...
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Feitosa, Mary F.
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Kanoni, Stavroul ...
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Smith, Caren E.
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Garcia, Melissa ...
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Tiainen, Anna-Ma ...
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Sonestedt, Emily
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Manichaikul, Ani
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van Rooij, Frank ...
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Dimitriou, Maria
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Raitakari, Olli
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Pankow, James S.
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Djousse, Luc
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Province, Michae ...
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Hu, Frank B.
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Lai, Chao-Qiang
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Keller, Margaux ...
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Peraelae, Mia-Ma ...
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Rotter, Jerome I ...
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Hofman, Albert
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Graff, Misa
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Kaehoenen, Mika
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Mukamal, Kenneth
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Johansson, Ingeg ...
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Ordovas, Jose M.
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Liu, Yongmei
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Maennistoe, Satu
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Uitterlinden, An ...
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Deloukas, Panos
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Seppaelae, Ilkka
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Psaty, Bruce M.
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Cupples, L. Adri ...
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Borecki, Ingrid ...
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Franks, Paul W.
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Arnett, Donna K.
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Nalls, Mike A.
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Eriksson, Johan ...
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Orho-Melander, M ...
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Franco, Oscar H.
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Lehtimaeki, Terh ...
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Dedoussis, Georg ...
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Meigs, James B.
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Siscovick, David ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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American Journal ...
- By the university
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Umeå University
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Lund University