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Apolipoprotein E ge...
Apolipoprotein E genotypes and longevity across dementia disorders
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- Skillbäck, Tobias (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Lautner, Ronald (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Mattsson, Niklas (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Lund University, Malmö, Sweden; Skåne University Hospital, Lund, Sweden,Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Malmö, Sweden; Skåne Univ Hosp, Dept Neurol, Lund, Sweden
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- Schott, Jonathan M (author)
- Dementia Research Centre, UCL Institute of Neurology, London, UK,University College London,UCL Inst Neurol, Dementia Res Ctr, London, England
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- Skoog, Ingmar (author)
- Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden,Univ Gothenburg, Neuropsychiat Epidemiol Unit, Dept Psychiat & Neurochem, Inst Neurosci & Physiol, Sahlgrenska Acad, Mölndal, Sweden
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- Nägga, Katarina (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Malmö, Sweden,Lund University, Malmö, Sweden
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- Kilander, Lena (author)
- Uppsala universitet,Uppsala University,Geriatrik,Uppsala University, Uppsala, Sweden
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- Wimo, Anders (author)
- Uppsala universitet,Uppsala University,Karolinska Institutet,Centrum för klinisk forskning, Gävleborg,Karolinska Inst, Div Neurogeriatr, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc NVS, Huddinge, Sweden,Karolinska Institutet, Huddinge, Sweden; Uppsala University/County Council of Gävleborg, Gävle, Sweden
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- Winblad, Bengt (author)
- Karolinska Institutet,Karolinska Institutet, Huddinge, Sweden; Karolinska University Hospital, Huddinge, Sweden,Karolinska Univ Hosp, Dept Geriatr Med, Huddinge, Sweden; Karolinska Inst, Div Neurogeriatr, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc NVS, Huddinge, Sweden
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- Eriksdotter, Maria (author)
- Karolinska Institutet,Karolinska Institutet, Huddinge, Sweden; Karolinska University Hospital, Huddinge, Sweden,Karolinska Univ Hosp, Dept Geriatr Med, Huddinge, Sweden; Karolinska Inst, Div Neurogeriatr, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc NVS, Huddinge, Sweden
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- Blennow, Kaj (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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(creator_code:org_t)
- 2018-03-13
- 2018
- English.
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In: Alzheimer's & Dementia. - : Elsevier. - 1552-5260 .- 1552-5279. ; 14:7, s. 895-901
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Abstract
Subject headings
Close
- INTRODUCTION: The ε4 allele of the apolipoprotein E (APOE) gene is a prominent risk factor for Alzheimer's disease (AD), but its implication in other dementias is less well studied.METHODS: We used a data set on 2858 subjects (1098 AD, 260 vascular dementia [VaD], 145 mixed AD and VaD, 90 other dementia diagnoses, and 1265 controls) to examine the association of APOE polymorphisms with clinical dementia diagnoses, biomarker profiles, and longevity.RESULTS: The ε4 allele was associated with reduced longevity as ε4 versus ε3 homozygotes lived on average 2.6 years shorter (P = .006). In AD, ε4 carriers lived 1.0 years shorter than noncarriers (P = .028). The ε4 allele was more prevalent in AD, mixed AD and VaD, and VaD patients compared to controls, but not in other dementia disorders.DISCUSSION: The APOE ε4 allele is influential in AD but might also be of importance in VaD and in mixed AD and VaD, diseases in which concomitant AD pathology is common.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- Apolipoprotein E
- Creutzfeldt-Jakob disease
- Dementia with Lewy bodies
- Frontotemporal dementia
- Parkinson's disease dementia
- Vascular dementia
- Alzheimer's disease
- Apolipoprotein E
- Creutzfeldt-Jakob disease
- Dementia with Lewy bodies
- Frontotemporal dementia
- Parkinson's disease dementia
- Vascular dementia
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Skillbäck, Tobia ...
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Lautner, Ronald
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Mattsson, Niklas
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Schott, Jonathan ...
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Skoog, Ingmar
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Nägga, Katarina
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Kilander, Lena
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Wimo, Anders
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Winblad, Bengt
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Eriksdotter, Mar ...
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Blennow, Kaj
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Zetterberg, Henr ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimer's & De ...
- By the university
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Linköping University
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Karolinska Institutet
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Lund University
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Uppsala University
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University of Gothenburg