AURKA F31I polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers: A consortium of investigators of modifiers of BRCA1/2 study

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Search: (WFRF:(Rebbeck Timothy R)) pers:(Spurdle Amanda B.) > AURKA F31I polymorp...

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MARC

Fältnamn	Indikatorer	Metadata
000		06201naa a2201129 4500
001		oai:lup.lub.lu.se:f7145c23-ede9-4d6b-ab85-90e71859726f
003		SwePub
008		160401s2007 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/6928092 URI
024	7	a https://doi.org/10.1158/1055-9965.EPI-07-01292 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Couch, Fergus J.4 aut
245	1 0	a AURKA F31I polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers: A consortium of investigators of modifiers of BRCA1/2 study
264	1	c 2007
520		a The AURKA oncogene is associated with abnormal chromosome segregation and aneuploidy and predisposition to cancer. Amplification of AURKA has been detected at higher frequency in tumors from BRCA1 and BRCA2 mutation carriers than in sporadic breast tumors, suggesting that overexpression of AURKA and inactivation of BRCA1 and BRCA2 cooperate during tumor development and progression. The F31I polymorphism in AURKA has been associated with breast cancer risk in the homozygous state in prior studies. We evaluated whether the AURKA F31I polymorphism modifies breast cancer risk in BRCA1 and BRCA2 mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2. Consortium of Investigators of Modifiers of BRCA1/2 was established to provide sufficient statistical power through increased numbers of mutation carriers to identify polymorphisms that act as modifiers of cancer risk and can refine breast cancer risk estimates in BRCA1 and BRCA2 mutation carriers. A total of 4,935 BRCA1 and 2,241 BRCA2 mutation carriers and 11 individuals carrying both BRCA1 and BRCA2 mutations was genotyped for F31I. Overall, homozygosity for the 311 allele was not significantly associated with breast cancer risk in BRCA1 and BRCA2 carriers combined [hazard ratio (HR), 0.91; 95% confidence interval (95% CI), 0.77-1.061. Similarly, no significant association was seen in BRCA1 (HR, 0.90; 95% Cl, 0.75-1.08) or BRCA2 carriers (HR, 0.93; 95% CI, 0.67-1.29) or when assessing the modifying effects of either bilateral prophylactic oophorectomy or menopausal status of BRCA1 and BRCA2 carriers. In summary, the F31I polymorphism in AURKA is not associated with a modified risk of breast cancer in BRCA1 and BRCA2 carriers.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
700	1	a Sinilnikova, Olga4 aut
700	1	a Vierkant, Robert A.4 aut
700	1	a Pankratz, V. Shane4 aut
700	1	a Fredericksen, Zachary S.4 aut
700	1	a Stoppa-Lyonnet, Dominique4 aut
700	1	a Coupier, Isabelle4 aut
700	1	a Hughes, David4 aut
700	1	a Hardouin, Agnes4 aut
700	1	a Berthet, Pascaline4 aut
700	1	a Peock, Susan4 aut
700	1	a Cook, Margaret4 aut
700	1	a Baynes, Caroline4 aut
700	1	a Hodgson, Shirley4 aut
700	1	a Morrison, Patrick J.4 aut
700	1	a Porteous, Mary E.4 aut
700	1	a Jakubowska, Anna4 aut
700	1	a Lubinski, Jan4 aut
700	1	a Gronwald, Jacek4 aut
700	1	a Spurdle, Amanda B.4 aut
700	1	a kConFab, [unknown]4 aut
700	1	a Schmutzler, Rita4 aut
700	1	a Versmold, Beatrix4 aut
700	1	a Engel, Christoph4 aut
700	1	a Meindl, Alfons4 aut
700	1	a Sutter, Christian4 aut
700	1	a Horst, Jurgen4 aut
700	1	a Schaefer, Dieter4 aut
700	1	a Offit, Kenneth4 aut
700	1	a Kirchhoff, Tomas4 aut
700	1	a Andrulis, Irene L.4 aut
700	1	a Ilyushik, Eduard4 aut
700	1	a Glendon, Gordon4 aut
700	1	a Devilee, Peter4 aut
700	1	a Vreeswijk, Maaike P. G.4 aut
700	1	a Vasen, Hans F. A.4 aut
700	1	a Borg, Åkeu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-abo
700	1	a Harbst, Katjau Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-kbn
700	1	a Struewing, Jeffery P.4 aut
700	1	a Greene, Mark H.4 aut
700	1	a Neuhausen, Susan L.4 aut
700	1	a Rebbeck, Timothy R.4 aut
700	1	a Nathanson, Katherine4 aut
700	1	a Domchek, Susan4 aut
700	1	a Wagner, Theresa4 aut
700	1	a Garber, Judy E.4 aut
700	1	a Szabo, Csilla4 aut
700	1	a Zikan, Michal4 aut
700	1	a Foretova, Lenka4 aut
700	1	a Olson, Janet E.4 aut
700	1	a Sellers, Thomas A.4 aut
700	1	a Lindor, Noralane4 aut
700	1	a Ll, Heli Nevanlinna4 aut
700	1	a Tommiska, Johanna4 aut
700	1	a Aittomaki, Kristiina4 aut
700	1	a Hamann, Ute4 aut
700	1	a Rashid, Muhammad U.4 aut
700	1	a Torres, Diana4 aut
700	1	a Simard, Jacques4 aut
700	1	a Durocher, Francine4 aut
700	1	a Guenard, Frederic4 aut
700	1	a Lynch, Henry T.4 aut
700	1	a Isaacs, Claudine4 aut
700	1	a Weitzel, Jeffrey4 aut
700	1	a Olopade, Olufunmilayo I.4 aut
700	1	a Narod, Steven4 aut
700	1	a Daly, Mary B.4 aut
700	1	a Godwin, Andrew K.4 aut
700	1	a Tomlinson, Gail4 aut
700	1	a Easton, Douglas F.4 aut
700	1	a Chenevix-Trench, Georgia4 aut
700	1	a Antoniou, Antonis C.4 aut
710	2	a Bröstcancer-genetikb Sektion I4 org
773	0	t Cancer Epidemiology Biomarkers & Preventiong 16:7, s. 1416-1421q 16:7<1416-1421x 1538-7755
856	4	u http://dx.doi.org/10.1158/1055-9965.EPI-07-0129x freey FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/692809
856	4 8	u https://doi.org/10.1158/1055-9965.EPI-07-0129

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By the author/editor: Couch, Fergus J.; Sinilnikova, Olg ...; Vierkant, Robert ...; Pankratz, V. Sha ...; Fredericksen, Za ...; Stoppa-Lyonnet, ...; show more...; Coupier, Isabell ...; Hughes, David; Hardouin, Agnes; Berthet, Pascali ...; Peock, Susan; Cook, Margaret; Baynes, Caroline; Hodgson, Shirley; Morrison, Patric ...; Porteous, Mary E ...; Jakubowska, Anna; Lubinski, Jan; Gronwald, Jacek; Spurdle, Amanda ...; kConFab, [unknow ...; Schmutzler, Rita; Versmold, Beatri ...; Engel, Christoph; Meindl, Alfons; Sutter, Christia ...; Horst, Jurgen; Schaefer, Dieter; Offit, Kenneth; Kirchhoff, Tomas; Andrulis, Irene ...; Ilyushik, Eduard; Glendon, Gordon; Devilee, Peter; Vreeswijk, Maaik ...; Vasen, Hans F. A ...; Borg, Åke; Harbst, Katja; Struewing, Jeffe ...; Greene, Mark H.; Neuhausen, Susan ...; Rebbeck, Timothy ...; Nathanson, Kathe ...; Domchek, Susan; Wagner, Theresa; Garber, Judy E.; Szabo, Csilla; Zikan, Michal; Foretova, Lenka; Olson, Janet E.; Sellers, Thomas ...; Lindor, Noralane; Ll, Heli Nevanli ...; Tommiska, Johann ...; Aittomaki, Krist ...; Hamann, Ute; Rashid, Muhammad ...; Torres, Diana; Simard, Jacques; Durocher, Franci ...; Guenard, Frederi ...; Lynch, Henry T.; Isaacs, Claudine; Weitzel, Jeffrey; Olopade, Olufunm ...; Narod, Steven; Daly, Mary B.; Godwin, Andrew K ...; Tomlinson, Gail; Easton, Douglas ...; Chenevix-Trench, ...; Antoniou, Antoni ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

Articles in the publication: Cancer Epidemiol ...

By the university: Lund University

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