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(WFRF:(Romieu Isabelle)) pers:(Clavel Chapelon Francoise)
 

Sökning: (WFRF:(Romieu Isabelle)) pers:(Clavel Chapelon Francoise) > Metabolic syndrome ...

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FältnamnIndikatorerMetadata
00004884naa a2200769 4500
001oai:DiVA.org:umu-49632
003SwePub
008111114s2011 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-496322 URI
0247 a https://doi.org/10.1158/1940-6207.CAPR-11-02182 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Aleksandrova, Krasimira4 aut
2451 0a Metabolic syndrome and risks of colon and rectal cancer :b the European prospective investigation into cancer and nutrition study.
264 1c 2011
338 a print2 rdacarrier
520 a Metabolic syndrome (MetS) is purportedly related to risk of developing colorectal cancer; however, the association of MetS, as defined according to recent international criteria, and colorectal cancer has not been yet evaluated. In particular, it remains unclear to what extent the MetS components individually account for such an association. We addressed these issues in a nested case-control study that included 1,093 incident cases matched (1:1) to controls by using incidence density sampling. Conditional logistic regression was used to estimate relative risks (RR) and 95% CIs. MetS was defined according to the criteria of the National Cholesterol Education Program/Adult Treatment Panel III (NCEP/ATPIII), the International Diabetes Federation (IDF), and the 2009 harmonized definition. Among individual components, abdominal obesity (RR = 1.51; 95% CI: 1.16-1.96) was associated with colon cancer, whereas abnormal glucose metabolism was associated with both colon (RR = 2.05; 95% CI: 1.57-2.68) and rectal cancer (RR = 2.07; 95% CI: 1.45-2.96). MetS, as defined by each of the definitions, was similarly associated with colon cancer (e.g., RR = 1.91; 95% CI: 1.47-2.42 for MetS by NCEP/ATPIII), whereas MetS by NCEP/ATPIII, but not IDF or harmonized definition, was associated with rectal cancer (RR = 1.45; 95% CI: 1.02-2.06). Overall, these associations were stronger in women than in men. However, the association between MetS and colorectal cancer was accounted for by abdominal obesity and abnormal glucose metabolism such that MetS did not provide risk information beyond these components (likelihood ratio test P = 0.10 for MetS by NCEP/ATPIII). These data suggest that simple assessment of abnormal glucose metabolism and/or abdominal obesity to identify individuals at colorectal cancer risk may have higher clinical utility than applying more complex MetS definitions. Cancer Prev Res; 4(11); 1873-83. ©2011 AACR.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Boeing, Heiner4 aut
7001 a Jenab, Mazda4 aut
7001 a Bas Bueno-de-Mesquita, H4 aut
7001 a Jansen, Eugene4 aut
7001 a van Duijnhoven, Fränzel J B4 aut
7001 a Fedirko, Veronika4 aut
7001 a Rinaldi, Sabina4 aut
7001 a Romieu, Isabelle4 aut
7001 a Riboli, Elio4 aut
7001 a Romaguera, Dora4 aut
7001 a Overvad, Kim4 aut
7001 a Ostergaard, Jane Nautrup4 aut
7001 a Olsen, Anja4 aut
7001 a Tjønneland, Anne4 aut
7001 a Boutron-Ruault, Marie-Christine4 aut
7001 a Clavel-Chapelon, Françoise4 aut
7001 a Morois, Sophie4 aut
7001 a Masala, Giovanna4 aut
7001 a Agnoli, Claudia4 aut
7001 a Panico, Salvatore4 aut
7001 a Tumino, Rosario4 aut
7001 a Vineis, Paolo4 aut
7001 a Kaaks, Rudolf4 aut
7001 a Lukanova, Annekatrin4 aut
7001 a Trichopoulou, Antonia4 aut
7001 a Naska, Androniki4 aut
7001 a Bamia, Christina4 aut
7001 a Peeters, Petra H4 aut
7001 a Rodríguez, Laudina4 aut
7001 a Buckland, Genevieve4 aut
7001 a Sánchez, María-José4 aut
7001 a Dorronsoro, Miren4 aut
7001 a Huerta, Jose-María4 aut
7001 a Barricarte, Aurelio4 aut
7001 a Hallmans, Göran,d 1947-u Umeå universitet,Näringsforskning4 aut0 (Swepub:umu)goha0001
7001 a Palmqvist, Richardu Umeå universitet,Patologi4 aut0 (Swepub:umu)ripa0001
7001 a Khaw, Kay-Tee4 aut
7001 a Wareham, Nicholas4 aut
7001 a Allen, Naomi E4 aut
7001 a Tsilidis, Konstantinos K4 aut
7001 a Pischon, Tobias4 aut
7102 a Umeå universitetb Näringsforskning4 org
7730 t Cancer prevention research (Philadelphia, Pa.)g 4:11, s. 1873-83q 4:11<1873-83x 1940-6215
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-49632
8564 8u https://doi.org/10.1158/1940-6207.CAPR-11-0218

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