Sökning: (WFRF:(Rominger Axel)) > Individual regional...
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000 | 04988naa a2200781 4500 | |
001 | oai:gup.ub.gu.se/335493 | |
003 | SwePub | |
008 | 240528s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/3354932 URI |
024 | 7 | a https://doi.org/10.1038/s41380-023-02188-82 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Finze, Anika4 aut |
245 | 1 0 | a Individual regional associations between Aβ-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies |
264 | 1 | c 2023 |
520 | a & beta;-amyloid (A & beta;) and tau aggregation as well as neuronal injury and atrophy (ATN) are the major hallmarks of Alzheimer's disease (AD), and biomarkers for these hallmarks have been linked to neuroinflammation. However, the detailed regional associations of these biomarkers with microglial activation in individual patients remain to be elucidated. We investigated a cohort of 55 patients with AD and primary tauopathies and 10 healthy controls that underwent TSPO-, A & beta;-, tau-, and perfusion-surrogate-PET, as well as structural MRI. Z-score deviations for 246 brain regions were calculated and biomarker contributions of A & beta; (A), tau (T), perfusion (N1), and gray matter atrophy (N2) to microglial activation (TSPO, I) were calculated for each individual subject. Individual ATN-related microglial activation was correlated with clinical performance and CSF soluble TREM2 (sTREM2) concentrations. In typical and atypical AD, regional tau was stronger and more frequently associated with microglial activation when compared to regional A & beta; (AD: & beta;(T) = 0.412 & PLUSMN; 0.196 vs. & beta;(A) = 0.142 & PLUSMN; 0.123, p < 0.001; AD-CBS: & beta;(T) = 0.385 & PLUSMN; 0.176 vs. & beta;(A) = 0.131 & PLUSMN; 0.186, p = 0.031). The strong association between regional tau and microglia reproduced well in primary tauopathies (& beta;(T) = 0.418 & PLUSMN; 0.154). Stronger individual associations between tau and microglial activation were associated with poorer clinical performance. In patients with 4RT, sTREM2 levels showed a positive association with tau-related microglial activation. Tau pathology has strong regional associations with microglial activation in primary and secondary tauopathies. Tau and A & beta; related microglial response indices may serve as a two-dimensional in vivo assessment of neuroinflammation in neurodegenerative diseases. | |
650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
700 | 1 | a Biechele, Gloria4 aut |
700 | 1 | a Rauchmann, Boris-Stephan4 aut |
700 | 1 | a Franzmeier, Nicolai,d 1989u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xfnico |
700 | 1 | a Palleis, Carla4 aut |
700 | 1 | a Katzdobler, Sabrina4 aut |
700 | 1 | a Weidinger, Endy4 aut |
700 | 1 | a Guersel, Selim4 aut |
700 | 1 | a Schuster, Sebastian4 aut |
700 | 1 | a Harris, Stefanie4 aut |
700 | 1 | a Schmitt, Julia4 aut |
700 | 1 | a Beyer, Leonie4 aut |
700 | 1 | a Gnoerich, Johannes4 aut |
700 | 1 | a Lindner, Simon4 aut |
700 | 1 | a Albert, Nathalie L.4 aut |
700 | 1 | a Wetzel, Christian H.4 aut |
700 | 1 | a Rupprecht, Rainer4 aut |
700 | 1 | a Rominger, Axel4 aut |
700 | 1 | a Danek, Adrian4 aut |
700 | 1 | a Burow, Lena4 aut |
700 | 1 | a Kurz, Carolin4 aut |
700 | 1 | a Tato, Maia4 aut |
700 | 1 | a Utecht, Julia4 aut |
700 | 1 | a Papazov, Boris4 aut |
700 | 1 | a Zaganjori, Mirlind4 aut |
700 | 1 | a Trappmann, Lena-Katharina4 aut |
700 | 1 | a Goldhardt, Oliver4 aut |
700 | 1 | a Grimmer, Timo4 aut |
700 | 1 | a Haeckert, Jan4 aut |
700 | 1 | a Janowitz, Daniel4 aut |
700 | 1 | a Buerger, Katharina4 aut |
700 | 1 | a Keeser, Daniel4 aut |
700 | 1 | a Stoecklein, Sophia4 aut |
700 | 1 | a Dietrich, Olaf4 aut |
700 | 1 | a Morenas-Rodriguez, Estrella4 aut |
700 | 1 | a Barthel, Henryk4 aut |
700 | 1 | a Sabri, Osama4 aut |
700 | 1 | a Bartenstein, Peter4 aut |
700 | 1 | a Simons, Mikael4 aut |
700 | 1 | a Haass, Christian4 aut |
700 | 1 | a Hoeglinger, Gunter U.4 aut |
700 | 1 | a Levin, Johannes4 aut |
700 | 1 | a Perneczky, Robert4 aut |
700 | 1 | a Brendel, Matthias4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
773 | 0 | t MOLECULAR PSYCHIATRYg 28:10, s. 4438-4450q 28:10<4438-4450x 1359-4184x 1476-5578 |
856 | 4 8 | u https://gup.ub.gu.se/publication/335493 |
856 | 4 8 | u https://doi.org/10.1038/s41380-023-02188-8 |
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