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Association of Atte...
Association of Attention-Deficit/Hyperactivity Disorder and Depression Polygenic Scores with Lithium Response: A Consortium for Lithium Genetics Study.
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Coombes, Brandon J (author)
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- Millischer, Vincent (author)
- Karolinska Institutet
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Batzler, Anthony (author)
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show more...
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Larrabee, Beth (author)
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Hou, Liping (author)
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Papiol, Sergi (author)
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Heilbronner, Urs (author)
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Adli, Mazda (author)
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Akiyama, Kazufumi (author)
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Akula, Nirmala (author)
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Amare, Azmeraw T (author)
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Ardau, Raffaella (author)
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Arias, Barbara (author)
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Aubry, Jean-Michel (author)
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- Backlund, Lena (author)
- Karolinska Institutet
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Bauer, Michael (author)
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Baune, Bernhard T (author)
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Bellivier, Frank (author)
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Benabarre, Antoni (author)
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Bengesser, Susanne (author)
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Bhattacharjee, Abesh Kumar (author)
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Cervantes, Pablo (author)
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Chen, Hsi-Chung (author)
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- Chillotti, Caterina (author)
- Karolinska Institutet
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Cichon, Sven (author)
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Clark, Scott R (author)
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Colom, Francesc (author)
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Cruceanu, Cristiana (author)
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Czerski, Piotr M (author)
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Dalkner, Nina (author)
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Degenhardt, Franziska (author)
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Del Zompo, Maria (author)
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DePaulo, J Raymond (author)
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Étain, Bruno (author)
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Falkai, Peter (author)
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Ferensztajn-Rochowiak, Ewa (author)
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Forstner, Andreas J (author)
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- Frisen, Louise (author)
- Karolinska Institutet
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Gard, Sébastien (author)
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Garnham, Julie S (author)
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Goes, Fernando S (author)
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Grigoroiu-Serbanescu, Maria (author)
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Grof, Paul (author)
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Hashimoto, Ryota (author)
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Hauser, Joanna (author)
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Herms, Stefan (author)
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Hoffmann, Per (author)
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Jamain, Stephane (author)
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Jiménez, Esther (author)
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Kahn, Jean-Pierre (author)
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Kassem, Layla (author)
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Kato, Tadafumi (author)
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Kelsoe, John R (author)
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Kittel-Schneider, Sarah (author)
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König, Barbara (author)
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Kuo, Po-Hsiu (author)
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Kusumi, Ichiro (author)
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Laje, Gonzalo (author)
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- Landén, Mikael, 1966 (author)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Lavebratt, Catharina (author)
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Leboyer, Marion (author)
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Leckband, Susan G (author)
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- Maj, Mario (author)
- Karolinska Institutet
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Manchia, Mirko (author)
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- Martinsson, Lina (author)
- Karolinska Institutet
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McCarthy, Michael J (author)
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McElroy, Susan L (author)
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Mitchell, Philip B (author)
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Mitjans, Marina (author)
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Mondimore, Francis M (author)
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Monteleone, Palmiero (author)
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Nievergelt, Caroline M (author)
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Nöthen, Markus M (author)
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Novák, Tomas (author)
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O'Donovan, Claire (author)
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Osby, Urban (author)
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Ozaki, Norio (author)
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Pfennig, Andrea (author)
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Pisanu, Claudia (author)
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Potash, James B (author)
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Reif, Andreas (author)
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Reininghaus, Eva (author)
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Rietschel, Marcella (author)
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Rouleau, Guy A (author)
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Rybakowski, Janusz K (author)
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Schalling, Martin (author)
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Schofield, Peter R (author)
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Schubert, Klaus Oliver (author)
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Schweizer, Barbara W (author)
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Severino, Giovanni (author)
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Shekhtman, Tatyana (author)
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Shilling, Paul D (author)
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Shimoda, Katzutaka (author)
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Simhandl, Christian (author)
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Slaney, Claire M (author)
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Squassina, Alessio (author)
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Stamm, Thomas (author)
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Stopkova, Pavla (author)
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Tortorella, Alfonso (author)
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Turecki, Gustavo (author)
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Vieta, Eduard (author)
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Witt, Stephanie H (author)
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Zandi, Peter P (author)
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Fullerton, Janice M (author)
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Alda, Martin (author)
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Frye, Mark A (author)
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Schulze, Thomas G (author)
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McMahon, Francis J (author)
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Biernacka, Joanna M (author)
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(creator_code:org_t)
- 2021-11-18
- 2021
- English.
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In: Complex psychiatry. - : S. Karger AG. - 2673-3005 .- 2673-298X. ; 7:3-4, s. 80-89
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Response to lithium varies widely between individuals with bipolar disorder (BD). Polygenic risk scores (PRSs) can uncover pharmacogenomics effects and may help predict drug response. Patients (N = 2,510) with BD were assessed for long-term lithium response in the Consortium on Lithium Genetics using the Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder score. PRSs for attention-deficit/hyperactivity disorder (ADHD), major depressive disorder (MDD), and schizophrenia (SCZ) were computed using lassosum and in a model including all three PRSs and other covariates, and the PRS of ADHD (β = -0.14; 95% confidence interval [CI]: -0.24 to -0.03; p value = 0.010) and MDD (β = -0.16; 95% CI: -0.27 to -0.04; p value = 0.005) predicted worse quantitative lithium response. A higher SCZ PRS was associated with higher rates of medication nonadherence (OR = 1.61; 95% CI: 1.34-1.93; p value = 2e-7). This study indicates that genetic risk for ADHD and depression may influence lithium treatment response. Interestingly, a higher SCZ PRS was associated with poor adherence, which can negatively impact treatment response. Incorporating genetic risk of ADHD, depression, and SCZ in combination with clinical risk may lead to better clinical care for patients with BD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Coombes, Brandon ...
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Millischer, Vinc ...
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Batzler, Anthony
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Larrabee, Beth
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Hou, Liping
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Papiol, Sergi
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show more...
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Heilbronner, Urs
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Adli, Mazda
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Akiyama, Kazufum ...
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Akula, Nirmala
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Amare, Azmeraw T
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Ardau, Raffaella
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Arias, Barbara
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Aubry, Jean-Mich ...
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Backlund, Lena
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Bauer, Michael
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Baune, Bernhard ...
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Bellivier, Frank
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Benabarre, Anton ...
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Bengesser, Susan ...
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Bhattacharjee, A ...
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Cervantes, Pablo
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Chen, Hsi-Chung
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Chillotti, Cater ...
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Cichon, Sven
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Clark, Scott R
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Colom, Francesc
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Cruceanu, Cristi ...
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Czerski, Piotr M
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Dalkner, Nina
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Degenhardt, Fran ...
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Del Zompo, Maria
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DePaulo, J Raymo ...
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Étain, Bruno
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Falkai, Peter
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Ferensztajn-Roch ...
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Forstner, Andrea ...
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Frisen, Louise
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Gard, Sébastien
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Garnham, Julie S
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Goes, Fernando S
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Grigoroiu-Serban ...
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Grof, Paul
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Hashimoto, Ryota
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Hauser, Joanna
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Herms, Stefan
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Hoffmann, Per
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Jamain, Stephane
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Jiménez, Esther
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Kahn, Jean-Pierr ...
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Kassem, Layla
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Kato, Tadafumi
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Kelsoe, John R
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Kittel-Schneider ...
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König, Barbara
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Kuo, Po-Hsiu
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Kusumi, Ichiro
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Laje, Gonzalo
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Landén, Mikael, ...
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Lavebratt, Catha ...
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Leboyer, Marion
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Leckband, Susan ...
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Maj, Mario
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Manchia, Mirko
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Martinsson, Lina
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McCarthy, Michae ...
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McElroy, Susan L
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Mitchell, Philip ...
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Mitjans, Marina
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Mondimore, Franc ...
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Monteleone, Palm ...
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Nievergelt, Caro ...
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Nöthen, Markus M
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Novák, Tomas
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O'Donovan, Clair ...
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Osby, Urban
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Ozaki, Norio
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Pfennig, Andrea
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Pisanu, Claudia
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Potash, James B
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Reif, Andreas
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Reininghaus, Eva
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Rietschel, Marce ...
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Rouleau, Guy A
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Rybakowski, Janu ...
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Schalling, Marti ...
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Schofield, Peter ...
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Schubert, Klaus ...
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Schweizer, Barba ...
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Severino, Giovan ...
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Shekhtman, Tatya ...
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Shilling, Paul D
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Shimoda, Katzuta ...
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Simhandl, Christ ...
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Slaney, Claire M
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Squassina, Aless ...
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Stamm, Thomas
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Stopkova, Pavla
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Tortorella, Alfo ...
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Turecki, Gustavo
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Vieta, Eduard
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Witt, Stephanie ...
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Zandi, Peter P
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Fullerton, Janic ...
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Alda, Martin
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Frye, Mark A
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Schulze, Thomas ...
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McMahon, Francis ...
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Biernacka, Joann ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Complex psychiat ...
- By the university
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University of Gothenburg
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Karolinska Institutet