(WFRF:(Strand Sven Erik))
Sökning: (WFRF:(Strand Sven Erik)) > (2020-2024) > Humanization, radio...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05287naa a2200469 4500 | |
| 001 | oai:lup.lub.lu.se:3fd8f991-c120-47cd-b263-e6b2f9bda772 | |
| 003 | SwePub | |
| 008 | 220127s2021 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:148490149 | |
| 024 | 7 | a https://lup.lub.lu.se/record/3fd8f991-c120-47cd-b263-e6b2f9bda7722 URI |
| 024 | 7 | a https://doi.org/10.3390/ph141212512 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1484901492 URI |
| 040 | a (SwePub)lud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Strand, Joannau Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Strålterapi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Radiation therapy,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)jo5371st |
| 245 | 1 0 | a Humanization, radiolabeling and biodistribution studies of an igg1-type antibody targeting uncomplexed psa for theranostic applications |
| 264 | c 2021-12-01 | |
| 264 | 1 | b MDPI AG,c 2021 |
| 520 | a Metastatic castration-resistant prostate cancer is today incurable. Conventional imaging methods have limited detection, affecting their ability to give an accurate outcome prognosis, and current therapies for metastatic prostate cancer are insufficient. This inevitably leads to patients relapsing with castration-resistant prostate cancer. Targeting prostate-specific antigens whose expression is closely linked to the activity in the androgen receptor pathway, and thus the pathogenesis of prostate cancer, is a possible way to increase specificity and reduce off-target effects. We have humanized and evaluated radioimmunoconjugates of a previously murine antibody, m5A10, targeting PSA intended for theranostics of hormone-refractory prostate cancer. The humanized antibody h5A10 was expressed in mammalian HEK293 cells transfected with the nucleotide sequences for the heavy and light chains of the antibody. Cell culture medium was filtered and purified by Protein G chromatography, and the buffer was changed to PBS pH 7.4 by dialysis. Murine and humanized 5A10 were conjugated with p-SCN-Bn-CHX-A”-DTPA. Surface plasmon resonance was used to characterize the binding to PSA of the immunoconjugates. Immunoconjugates were labeled with either indium-111 or lutetium-177. Biodistribution studies of murine and humanized 5A10 were performed in mice with LNCaP xenografts. 5A10 was successfully humanized, and in vivo targeting showed specific binding in xenografts. The results thus give an excellent platform for further theranostic development of humanized 5A10 for clinical applications. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a 5A10 | |
| 653 | a FPSA | |
| 653 | a Humanization | |
| 653 | a Imaging | |
| 653 | a Prostate cancer | |
| 653 | a Theranostics | |
| 700 | 1 | a Sjöström, Kjellu Innovagen AB4 aut |
| 700 | 1 | a Lamminmaki, Urpo J.u University of Turku4 aut |
| 700 | 1 | a Timmermand, Oskar Vilhelmssonu Lund University,Lunds universitet,Forskningsgruppen för Systemisk strålterapi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Strålterapi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Systemic Radiation Therapy Group,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Radiation therapy,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)immu-orv |
| 700 | 1 | a Strand, Sven Eriku Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Forskningsgruppen för Systemisk strålterapi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Strålterapi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Systemic Radiation Therapy Group,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Radiation therapy,Section I,Department of Clinical Sciences, Lund4 aut0 (Swepub:lu)rafy-ses |
| 700 | 1 | a Tran, Thuy A.u Karolinska Institutet,Karolinska Institute,Karolinska University Hospital4 aut0 (Swepub:lu)med-tht |
| 710 | 2 | a LUCC: Lunds universitets cancercentrumb Övriga starka forskningsmiljöer4 org |
| 773 | 0 | t Pharmaceuticalsd : MDPI AGg 14:12q 14:12x 1424-8247 |
| 856 | 4 | u http://dx.doi.org/10.3390/ph14121251x freey FULLTEXT |
| 856 | 4 | u https://www.mdpi.com/1424-8247/14/12/1251/pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/3fd8f991-c120-47cd-b263-e6b2f9bda772 |
| 856 | 4 8 | u https://doi.org/10.3390/ph14121251 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:148490149 |
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