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Sökning: (WFRF:(Sundin Anders)) srt2:(2020-2024) > Cystatin C–Based Eq...

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FältnamnIndikatorerMetadata
00009620naa a2200649 4500
001oai:lup.lub.lu.se:689aaf61-e0d4-4b6f-948e-f10f96721f5b
003SwePub
008230129s2023 | |||||||||||000 ||eng|
009oai:DiVA.org:oru-103948
009oai:prod.swepub.kib.ki.se:153926462
0247 a https://lup.lub.lu.se/record/689aaf61-e0d4-4b6f-948e-f10f96721f5b2 URI
0247 a https://doi.org/10.1056/NEJMoa22037692 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1039482 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1539264622 URI
040 a (SwePub)lud (SwePub)orud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Pottel, Hansu Catholic University of Leuven,Department of Public Health and Primary Care, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium4 aut
2451 0a Cystatin C–Based Equation to Estimate GFR without the Inclusion of Race and Sex
264 1b Massachusetts Medical Society,c 2023
520 a BACKGROUNDThe accuracy of estimation of kidney function with the use of routine metabolic tests, such as measurement of the serum creatinine level, has been controversial. The European Kidney Function Consortium (EKFC) developed a creatinine-based equation (EKFC eGFRcr) to estimate the glomerular filtration rate (GFR) with a rescaled serum creatinine level (i.e., the serum creatinine level is divided by the median serum creatinine level among healthy persons to control for variation related to differences in age, sex, or race). Whether a cystatin C–based EKFC equation would increase the accuracy of estimated GFR is unknown.METHODSWe used data from patients in Sweden to estimate the rescaling factor for the cystatin C level in adults. We then replaced rescaled serum creatinine in the EKFC eGFRcr equation with rescaled cystatin C, and we validated the resulting EKFC eGFRcys equation in cohorts of White patients and Black patients in Europe, the United States, and Africa, according to measured GFR, levels of serum creatinine and cystatin C, age, and sex.RESULTSOn the basis of data from 227,643 patients in Sweden, the rescaling factor for cystatin C was estimated at 0.83 for men and women younger than 50 years of age and 0.83+0.005×(age–50) for those 50 years of age or older. The EKFC eGFRcys equation was unbiased, had accuracy that was similar to that of the EKFC eGFRcr equation in both White patients and Black patients (11,231 patients from Europe, 1093 from the United States, and 508 from Africa), and was more accurate than the Chronic Kidney Disease Epidemiology Collaboration eGFRcys equation recommended by Kidney Disease: Improving Global Outcomes. The arithmetic mean of EKFC eGFRcr and EKFC eGFRcys further improved the accuracy of estimated GFR over estimates from either biomarker equation alone.CONCLUSIONSThe EKFC eGFRcys equation had the same mathematical form as the EKFC eGFRcr equation, but it had a scaling factor for cystatin C that did not differ according to race or sex. In cohorts from Europe, the United States, and Africa, this equation improved the accuracy of GFR assessment over that of commonly used equations.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
653 a cystatin C, creatinine, GFR,
7001 a Björk, Jonasu Lund University,Lunds universitet,Kirurgi och folkhälsa,Forskargrupper vid Lunds universitet,Miljöepidemiologi,EPI@LUND,Surgery and public health,Lund University Research Groups,Environmental Epidemiology,Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden; Clinical Studies Sweden, Forum South, Skåne University Hospital, Lund, Sweden4 aut0 (Swepub:lu)ymed-jbj
7001 a Rule, Andrew D.u Mayo Clinic Minnesota,Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA4 aut
7001 a Ebert, Natalieu Charité - University Medicine Berlin,Charité Universitätsmedizin Berlin, Institute of Public Health, Berlin, Germany4 aut
7001 a Eriksen, Bjørn O.u UiT The Arctic University of Norway, Tromsø,Section of Nephrology, University Hospital of North Norway and Metabolic and Renal Research Group, Universitetet i Tromsø; Tromsø, Norway; Arctic University of Norway, Tromsø, Norway4 aut
7001 a Dubourg, Laurenceu Service de Néphrologie, Dialyse, Hypertension et Explorations Fonctionnelles Rénales, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France4 aut
7001 a Vidal-Petiot, Emmanuelleu Hopital Bichat-Claude-Bernard AP-HP,Bichat Hospital, Paris, France; Université de Paris, INSERM Unité 1149, Paris, France4 aut
7001 a Grubb, Andersu Lund University,Lunds universitet,Cystatin C, njursjukdom, amyloidos och antibiotika,Forskargrupper vid Lunds universitet,Cystatin C, renal disease, amyloidosis and antibiotics,Lund University Research Groups,Department of Clinical Chemistry, Skåne University Hospital, Lund4 aut0 (Swepub:lu)kkem-agr
7001 a Hansson, Magnusu Karolinska Institutet,Karolinska Institute,Function Area Clinical Chemistry, Karolinska University Laboratory, Karolinska University Hospital, Huddinge, Sweden; Department of Laboratory Medicine, Karolinska Institutet of Medical Sciences, Stockholm, Sweden4 aut
7001 a Lamb, Edmund J.u Kent and Canterbury Hospital,Clinical Biochemistry, East Kent Hospitals University NHS Foundation Trust, Canterbury, United Kingdom4 aut
7001 a Littmann, Karinu Karolinska Institutet,Karolinska Institute,Division of Clinical Chemistry, Karolinska Institutet of Medical Sciences, Huddinge, Sweden4 aut
7001 a Mariat, Christopheu Hopital Nord CHU de Sainte-Etienne,Service de Néphrologie, Dialyse et Transplantations Rénales, Hôpital Nord, Centre Hospitalier Universitaire de Saint-Étienne, Saint-Étienne, France4 aut
7001 a Melsom, Toralfu UiT The Arctic University of Norway, Tromsø,Section of Nephrology, University Hospital of North Norway and Metabolic and Renal Research Group, Universitetet i Tromsø; Tromsø, Norway; Arctic University of Norway, Tromsø, Norway4 aut
7001 a Schaeffner, Elkeu Charité Universitätsmedizin Berlin, Institute of Public Health, Berlin, Germany4 aut
7001 a Sundin, Per-Ola,d 1971-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Geriatrics, School Department of Laboratory Medicine, Karolinska Institutet of Medical Sciences, Stockholm, Sweden4 aut0 (Swepub:oru)pasn
7001 a Åkesson, Annau Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,EPI@LUND,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups,Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden; Clinical Studies Sweden, Forum South, Skåne University Hospital, Lund, Sweden4 aut0 (Swepub:lu)stat-aas
7001 a Larsson, Andersu Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden4 aut
7001 a Cavalier, Etienneu Departments of Clinical Chemistry, University of Liège, Belgium4 aut
7001 a Bukenya, Justineu Renal Unit, Department of Internal Medicine, Kinshasa University Hospital, University of Kinshasa, Kinshasa, Democratic Republic of Congo4 aut
7001 a Sumaili, Ernest K.u Renal Unit, Department of Internal Medicine, Kinshasa University Hospital, University of Kinshasa, Kinshasa, Democratic Republic of Congo4 aut
7001 a Yayo, Ericu Département de Biochimie, Unité de Formation et de Recherche Sciences Pharmaceutiques et Biologiques, Université Felix Houphouët Boigny, Abidjan, Ivory Coast4 aut
7001 a Monnet, Daguiu Département de Biochimie, Unité de Formation et de Recherche Sciences Pharmaceutiques et Biologiques, Université Felix Houphouët Boigny, Abidjan, Ivory Coast4 aut
7001 a Flamant, Martinu AP-HP, Bichat Hospital, Paris, France; Université de Paris, Unité Mixte de Recherche S1138, Cordeliers Research Center, Paris, France4 aut
7001 a Nyman, Ulfu Lund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Radiology Diagnostics, Malmö,Lund University Research Groups,Department of Translational Medicine, Division of Medical Radiology, Lund University, Malmö, Sweden4 aut0 (Swepub:lu)ront-uny
7001 a Delanaye, Pierreu Nephrology–Dialysis–Transplantation, University of Liège, Liège, Belgium; Department of Nephrology–Dialysis–Apheresis, Hôpital Universitaire Carémeau, Nîmes, France4 aut
7102 a Catholic University of Leuvenb Department of Public Health and Primary Care, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium4 org
7730 t The New England journal of medicined : Massachusetts Medical Societyg 388:4, s. 333-343q 388:4<333-343x 0028-4793x 1533-4406
8564 u http://dx.doi.org/10.1056/NEJMoa2203769y FULLTEXT
8564 8u https://lup.lub.lu.se/record/689aaf61-e0d4-4b6f-948e-f10f96721f5b
8564 8u https://doi.org/10.1056/NEJMoa2203769
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-103948
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:153926462

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