(WFRF:(Svensson J.)) hsvcat:3
Search: (WFRF:(Svensson J.)) hsvcat:3 > (2010-2014) > Differences between...
- 5 of 107
- Previous record
- Next record
- To hitlist
Differences between men and women in the regulation of adipose 11 beta-HSD1 and in its association with adiposity and insulin resistance
- deSchoolmeester, J. (author)
- Palming, J. (author)
- Persson, T. (author)
- show more...
- Brown, H. (author)
- Gill, D. (author)
- Svensson, M. K. (author)
- Rees, A. (author)
- Eriksson, J. W. (author)
- show less...
- (creator_code:org_t)
- 2013-06-20
- 2013
- English.
- In: Diabetes, obesity and metabolism. - : Wiley-Blackwell. - 1462-8902 .- 1463-1326. ; 15:11, s. 1056-1060
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- This study explored sex differences in 11-hydroxysteroid dehydrogenase type 1 (11-HSD1) activity and gene expression in isolated adipocytes and adipose tissue (AT), obtained via subcutaneous biopsies from non-diabetic subjects [58 M, 64 F; age 48.3 +/- 15.3years, body mass index (BMI) 27.2 +/- 3.9kg/m(2)]. Relationships with adiposity and insulin resistance (IR) were addressed. Males exhibited higher 11-HSD1 activity in adipocytes than females, but there was no such difference for AT. In both men and women, adipocyte 11-HSD1 activity correlated positively with BMI, waist circumference, % body fat, adipocyte size and with serum glucose, triglycerides and low-density lipoprotein:high-density lipoprotein (LDL:HDL) ratio. Positive correlations with insulin, HOMA-IR and haemoglobin A1c (HbA1c) and a negative correlation with HDL-cholesterol were significant only in males. Conversely, 11-HSD1 activity in AT correlated with several markers of IR and adiposity in females but not in males, but the opposite pattern was found with respect to 11-HSD1 mRNA expression. This study suggests that there are sex differences in 11-HSD1 regulation and in its associations with markers of obesity and IR.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- 11β-hydroxysteroid dehydrogenase type 1
- 11 beta-hydroxysteroid dehydrogenase type 1
- adipose tissue
- adipocytes
- obesity
- sex
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Diabetes, obesity and metabolism (Search for host publication in LIBRIS)
To the university's database
- 5 of 107
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- deSchoolmeester, ...
- Palming, J.
- Persson, T.
- Pereira, Maria J
- Eriksson, Jan W
- Brown, H.
- show more...
- Gill, D.
- Renström, Frida
- Lundgren, M.
- Svensson, M. K.
- Rees, A.
- Eriksson, J. W.
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Endocrinology an ...
- Articles in the publication
- Diabetes, obesit ...
- By the university
- Umeå University
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
