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Genetic variation i...
Genetic variation in the lactase gene, dairy product intake and risk for prostate cancer in the European prospective investigation into cancer and nutrition
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Travis, Ruth C. (author)
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Appleby, Paul N. (author)
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Siddiq, Afshan (author)
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Allen, Naomi E. (author)
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Kaaks, Rudolf (author)
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Canzian, Federico (author)
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Feller, Silke (author)
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Tjønneland, Anne (author)
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Føns Johnsen, Nina (author)
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Overvad, Kim (author)
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Ramon Quiros, J. (author)
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Gonzalez, Carlos A. (author)
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Sanchez, Maria-Jose (author)
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Larranaga, Nerea (author)
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Chirlaque, Maria-Dolores (author)
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Barricarte, Aurelio (author)
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Khaw, Kay-Tee (author)
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Wareham, Nick (author)
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Trichopoulou, Antonia (author)
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Valanou, Elisavet (author)
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Oustoglou, Erifili (author)
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Palli, Domenico (author)
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Sieri, Sabina (author)
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Tumino, Rosario (author)
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Sacerdote, Carlotta (author)
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Bueno-de-Mesquita, H. B(as). (author)
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- Stattin, Pär (author)
- Umeå universitet,Urologi och andrologi,Institutionen för folkhälsa och klinisk medicin
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Ferrari, Pietro (author)
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- Johansson, Mattias (author)
- Umeå universitet,Urologi och andrologi,International Agency for Research on Cancer (IARC), Lyon, France
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Norat, Teresa (author)
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Riboli, Elio (author)
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Key, Timothy J. (author)
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(creator_code:org_t)
- 2012-10-17
- 2013
- English.
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 132:8, s. 1901-1910
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- High dairy protein intake has been found to be associated with increased prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). To further examine this possible relationship, we investigated the hypothesis that a genetic polymorphism in the lactase (LCT) gene might be associated with elevated dairy product intake and increased prostate cancer risk in a casecontrol study nested in EPIC. The C/T-13910 lactase variant (rs4988235) was genotyped in 630 men with prostate cancer and 873 matched control participants. Dairy product consumption was assessed by diet questionnaire. Odds ratios (ORs) for prostate cancer in relation to lactase genotype were estimated by conditional logistic regression. Lactase genotype frequency varied significantly between countries, with frequencies of the T (lactase persistence) allele ranging from 7% in Greece to 79% in Denmark. Intake of milk and total dairy products varied significantly by lactase genotype after adjustment for recruitment center; adjusted mean intakes of milk were 44.4, 69.8 and 82.3 g/day among men with CC, CT and TT genotypes, respectively. The lactase variant was not significantly associated with prostate cancer risk, both in our data (adjusted OR for TT vs. CC homozygotes: 1.10, 95% CI: 0.761.59) and in a meta-analysis of all the published data (combined OR for T allele carriers vs. CC homozygotes: 1.12, 0.961.32). These findings show that while variation in the lactase gene is associated with milk intake in men, the lactase polymorphism does not have a large effect on prostate cancer risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- prostate cancer
- polymorphism
- genetic
- lactase
- dairy
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Travis, Ruth C.
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Appleby, Paul N.
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Siddiq, Afshan
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Allen, Naomi E.
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Kaaks, Rudolf
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Canzian, Federic ...
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show more...
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Feller, Silke
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Tjønneland, Anne
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Føns Johnsen, Ni ...
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Overvad, Kim
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Ramon Quiros, J.
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Gonzalez, Carlos ...
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Sanchez, Maria-J ...
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Larranaga, Nerea
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Chirlaque, Maria ...
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Barricarte, Aure ...
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Khaw, Kay-Tee
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Wareham, Nick
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Trichopoulou, An ...
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Valanou, Elisave ...
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Oustoglou, Erifi ...
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Palli, Domenico
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Sieri, Sabina
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Tumino, Rosario
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Sacerdote, Carlo ...
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Bueno-de-Mesquit ...
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Stattin, Pär
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Ferrari, Pietro
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Johansson, Matti ...
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Norat, Teresa
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Riboli, Elio
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Key, Timothy J.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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International Jo ...
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Umeå University