Covered stent placement for treatment of coarctation of the aorta: immediate and long-term results.

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Fältnamn	Indikatorer	Metadata
000		03992naa a2200373 4500
001		oai:gup.ub.gu.se/297431
003		SwePub
008		240528s2021 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://gup.ub.gu.se/publication/2974312 URI
024	7	a https://doi.org/10.1080/00015385.2020.18381262 DOI
040		a (SwePub)gu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Stassen, Jan4 aut
245	1 0	a Covered stent placement for treatment of coarctation of the aorta: immediate and long-term results.
264		c 2020-10-28
264	1	b Informa UK Limited,c 2021
520		a This study aimed to describe the safety and efficacy of covered stents in patients with coarctation of aorta (CoA) for immediate and long-term follow-up.Covered stents are increasingly being used in (re)CoA, mainly to reduce the risk of aortic wall injuries (AWI). However, limited data are available on intermediate and long-term outcome.In 89 patients (67.4% male) with a mean age of 23.9±15.8 (min max range 5.1-71.6) years were 102 covered stents implanted (January 2003 - December 2017). Short-term pre/post-implant hemodynamics and angiographic data were reported. Changes in blood pressure, the use of antihypertensive drugs and complications were recorded during follow-up.The procedural success rate was 100%. The mean invasive ascending-to-descending aorta systolic gradient under general anaesthesia decreased from 25±16mmHg to 4±7mmHg (p<0.001). After a mean follow-up time of 6.6±3.7years, there was a persistent improvement of the mean systolic blood pressure gradient between right arm and leg (-7±18 vs 38±24mmHg; p<0.001). A larger proportion of patients required antihypertensive medication (33.7% vs 50.0%, p=0.017) and needed ≥ 2 drugs (20.2% vs 27.4%, p=0.066) to control blood pressure. Long-term adverse events were found in 4.5% of patients [covered stent fracture (n=3), aneurysm formation (n=2)].Covered stent implantation for CoA is highly successful, safe and results in a persistent hemodynamic improvement in the immediate and long-term outcome. Lifelong follow-up with additional antihypertensive drug treatment is mandatory to maintain favourable hemodynamic results after stenting.Long-term follow-up data on covered stents in patients with coarctation of the aorta are scarce. A cohort of 89 patients was reviewed. The procedural implantation success rate was 100%. The invasive gradient decreased from 25±16mmHg to 4±7mmHg (p<0.001). After follow-up of 6.6±3.7years, there was a persistent improvement of the clinical systolic blood pressure gradient (-7±18 vs 38±24mmHg; p<0.001). However, a larger proportion of patients required antihypertensive medication (33.7% vs 50.0%, p=0.017). Covered stent implantation results in favourable hemodynamic effects, but lifelong follow-up with additional antihypertensive drug treatment is mandatory to maintain these results.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskap0 (SwePub)3032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciences0 (SwePub)3032 hsv//eng
700	1	a De Meester, Pieter4 aut
700	1	a Troost, Els4 aut
700	1	a Roggen, Leen4 aut
700	1	a Moons, Philip,d 1968u Gothenburg University,Göteborgs universitet,Institutionen för vårdvetenskap och hälsa,Institute of Health and Care Sciences4 aut0 (Swepub:gu)xmooph
700	1	a Gewillig, Marc4 aut
700	1	a Van De Bruaene, Alexander4 aut
700	1	a Budts, Werner4 aut
710	2	a Göteborgs universitetb Institutionen för vårdvetenskap och hälsa4 org
773	0	t Acta cardiologicad : Informa UK Limitedg 76:5, s. 464-472q 76:5<464-472x 1784-973Xx 0001-5385x 0373-7934
856	4	u https://lirias.kuleuven.be/bitstream/123456789/663093/3/Manuscript_CoA_09_10_2020_postprint.pdf
856	4 8	u https://gup.ub.gu.se/publication/297431
856	4 8	u https://doi.org/10.1080/00015385.2020.1838126

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By the author/editor: Stassen, Jan; De Meester, Piet ...; Troost, Els; Roggen, Leen; Moons, Philip, 1 ...; Gewillig, Marc; show more...; Van De Bruaene, ...; Budts, Werner; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences

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By the university: University of Gothenburg

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