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Antinuclear antibod...
Antinuclear antibodies in the oldest-old women and men
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- Nilsson, Bengt-Olof, 1954- (author)
- Linköpings universitet,Infektionsmedicin,Hälsouniversitetet
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- Skogh, Thomas, 1952- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Reumatologi,Hälsouniversitetet,Länskliniken för Reumatologi i Östergötland
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- Ernerudh, Jan, 1952- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Klinisk immunologi,Hälsouniversitetet,Klinisk immunologi och transfusionsmedicin
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- Johansson, Boo (author)
- Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology,Department of Psychology, Göteborg University, Göteborg, Sweden
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- Lofgren, S (author)
- Department of Microbiology, Ryhov Hospital, Jönköping, Sweden
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- Wikby, A (author)
- Institute of Gerontology, School of Health Sciences, Jönköping, Sweden
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- Dahle, Charlotte, 1956- (author)
- Linköpings universitet,Klinisk immunologi,Hälsouniversitetet
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(creator_code:org_t)
- Elsevier, 2006
- 2006
- English.
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In: Journal of Autoimmun. - : Elsevier. ; 27:4, s. 281-288
- Related links:
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https://gup.ub.gu.se...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The aim of this study was to compare the prevalence of antinuclear antibodies (ANA) in very old individuals (>/=86years of age) with healthy younger (18-68years) blood donors (n=200) regarding gender, health status, ratio of circulating CD4/CD8 cells and cytomegalovirus (CMV) serology. Frozen plasma was used for ANA detection in two study groups, i.e. 'OCTO' (97 persons aged 86-92years, 65% women) and 'NONA' (136 persons aged 86-95years, 70% women). OCTO participants were recruited on the basis that they were healthy or moderately healthy according to a selection protocol. No exclusion criteria regarding health status were applied in the NONA sample. The prevalence of ANA was significantly higher in the oldest-old samples compared to blood donors. There was no association between health status and the presence of ANA in the oldest-old. The difference across age was most pro-nounced in men, with low levels at younger age, whereas the prevalence among the oldest-old men reached similar levels as in women. There were no associations between the presence of ANA and CD4/CD8 ratio or with CMV status in the oldest-old. Our findings confirm an in-creased prevalence of ANA in the oldest-old, and emphasize the importance of taking gender and age into consideration when evaluating ANA.
Subject headings
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Keyword
- antinuclear antibody
- CD4/CD8
- CMV
- middle-aged
- oldest-old
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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