Sökning: L773:1791 7530 OR L773:0250 7005
> (2010-2014) >
Mutations of mitoch...
Mutations of mitochondrial DNA as potential biomarkers in breast cancer
-
Cai, Feng Feng (författare)
-
Kohler, Corina (författare)
-
Zhang, Bei (författare)
-
visa fler...
-
Chen, Wei Jie (författare)
-
Barekati, Zeinab (författare)
-
Garritsen, Henk SP (författare)
-
- Lenner, Per (författare)
- Umeå universitet,Onkologi
-
Toniolo, Paolo (författare)
-
Zhang, Jing Jie (författare)
-
Zhong, Xiao Yan (författare)
-
visa färre...
-
(creator_code:org_t)
- 2011
- 2011
- Engelska.
-
Ingår i: Anticancer Research. - 0250-7005 .- 1791-7530. ; 31:12, s. 4267-4271
- Relaterad länk:
-
https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Background: Alterations of mitochondrial DNA (mtDNA) have been found in cancer patients, therefore informative mtDNA mutations could serve as biomarkers for the disease. Materials and Methods: The two hypervariable regions HVR1 and HVR2 in the D-Loop region were sequenced in ten paired tissue and plasma samples from breast cancer patients. Results: MtDNA mutations were found in all patients' samples, suggesting a 100% detection rate. Examining germline mtDNA mutations, a total of 85 mutations in the D-loop region were found; 31 of these mutations were detected in both tissues and matched plasma samples, the other 54 germline mtDNA mutations were found only in the plasma samples. Regarding somatic mtDNA mutations, a total of 42 mutations in the D-loop region were found in breast cancer tissues. Conclusion: Somatic mtDNA mutations in the D-loop region were detected in breast cancer tissues but not in the matched plasma samples, suggesting that more sensitive methods will be needed for such detection to be of clinical utility.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- MtDNA mutation
- D-loop region
- breast cancer
- plasma
- mitochondrial DNA
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Cai, Feng Feng
-
Kohler, Corina
-
Zhang, Bei
-
Chen, Wei Jie
-
Barekati, Zeinab
-
Garritsen, Henk ...
-
visa fler...
-
Lenner, Per
-
Toniolo, Paolo
-
Zhang, Jing Jie
-
Zhong, Xiao Yan
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
- Artiklar i publikationen
-
Anticancer Resea ...
- Av lärosätet
-
Umeå universitet