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UCP1 ablation induc...
UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality.
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- Feldmann, Helena M. (author)
- Stockholms universitet,Avdelningen för fysiologi
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- Golozoubova, Valeria (author)
- Stockholms universitet,Wenner-Grens institut
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- Cannon, Barbara (author)
- Stockholms universitet,Avdelningen för fysiologi
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- Nedergaard, Jan (author)
- Stockholms universitet,Avdelningen för fysiologi
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(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- English.
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In: Cell metabolism. - : Elsevier BV. - 1932-7420 .- 1550-4131. ; 9:2, s. 203-9
- Related links:
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- As original studies of UCP1-ablated mice failed to demonstrate an obesogenic effect, alternative mechanisms for adaptive adrenergic thermogenesis have been sought. However, we demonstrate here that in C57Bl6 mice exempt from thermal stress (i.e., kept at thermoneutrality), UCP1 ablation in itself induced obesity, even in mice fed control diet, and vastly augmented diet-induced obesity (high-fat diet); i.e., the mice exhibited increased metabolic efficiency. In wild-type mice, high-fat diet increased norepinephrine-induced thermogenesis; i.e., diet-induced thermogenesis was observed, but no such effect was observed in UCP1-ablated mice, demonstrating that diet-induced thermogenesis fully emanates from UCP1 activity. We conclude that ambient temperature is qualitatively determinative for the outcome of metabolic studies, that no other protein and no other mechanism can substitute for UCP1 in mediating diet-induced adrenergic thermogenesis, and that UCP1 activity can be determinative for obesity development in mice and possibly in humans.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- HUMDISEASE
- Physiology and pharmacology
- Fysiologi och farmakologi
- fysiologi
- Physiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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